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Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure–activity/property relationship-based approach in the study of bioavailability and bioactivity

(2015) DRUG METABOLISM REVIEWS. 47(2). p.175-190
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Abstract
Flavonoids are a group of polyphenols that provide health-promoting benefits upon consumption. However, poor bioavailability has been a major hurdle in their use as drugs or nutraceuticals. Low bioavailability has been associated with flavonoid interactions at various stages of the digestion, absorption and distribution process, which is strongly affected by their molecular structure. In this review, we use structure–activity/property relationship to discussvariou s flavonoid interactions with food matrices, digestive enzymes, intestinal transporters and blood proteins. This approach reveals specific bioactive properties of flavonoids in the gastrointestinal tract as well as various barriers for their bioavailability. In the last part of this review, we use these insights to determine the effect of different structural characteristics on the overall bioavailability of flavonoids. Such information is crucial when flavonoid or flavonoid derivatives are used as active ingredients in foods or drugs.
Keywords
ABC transporters, glucuronidation, amylase, flavonoids, lipase, mucus layer, protein-flavonoid interaction, QSAR, sulfation, CANCER RESISTANCE PROTEIN, CACO-2/HT29-MTX COCULTURE MODEL, BOVINE-MILK PROTEINS, P-GLYCOPROTEIN, ALPHA-AMYLASE, INTESTINAL-ABSORPTION, DIETARY POLYPHENOLS, PHENOLIC-COMPOUNDS, DRUG DISCOVERY, AFFINITY RELATIONSHIP

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MLA
Gonzales, Gerard, Guy Smagghe, Charlotte Grootaert, et al. “Flavonoid Interactions During Digestion, Absorption, Distribution and Metabolism: a Sequential Structure–activity/property Relationship-based Approach in the Study of Bioavailability and Bioactivity.” DRUG METABOLISM REVIEWS 47.2 (2015): 175–190. Print.
APA
Gonzales, G., Smagghe, G., Grootaert, C., Zotti, M. J., Raes, K., & Van Camp, J. (2015). Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure–activity/property relationship-based approach in the study of bioavailability and bioactivity. DRUG METABOLISM REVIEWS, 47(2), 175–190.
Chicago author-date
Gonzales, Gerard, Guy Smagghe, Charlotte Grootaert, Moises João Zotti, Katleen Raes, and John Van Camp. 2015. “Flavonoid Interactions During Digestion, Absorption, Distribution and Metabolism: a Sequential Structure–activity/property Relationship-based Approach in the Study of Bioavailability and Bioactivity.” Drug Metabolism Reviews 47 (2): 175–190.
Chicago author-date (all authors)
Gonzales, Gerard, Guy Smagghe, Charlotte Grootaert, Moises João Zotti, Katleen Raes, and John Van Camp. 2015. “Flavonoid Interactions During Digestion, Absorption, Distribution and Metabolism: a Sequential Structure–activity/property Relationship-based Approach in the Study of Bioavailability and Bioactivity.” Drug Metabolism Reviews 47 (2): 175–190.
Vancouver
1.
Gonzales G, Smagghe G, Grootaert C, Zotti MJ, Raes K, Van Camp J. Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure–activity/property relationship-based approach in the study of bioavailability and bioactivity. DRUG METABOLISM REVIEWS. 2015;47(2):175–90.
IEEE
[1]
G. Gonzales, G. Smagghe, C. Grootaert, M. J. Zotti, K. Raes, and J. Van Camp, “Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure–activity/property relationship-based approach in the study of bioavailability and bioactivity,” DRUG METABOLISM REVIEWS, vol. 47, no. 2, pp. 175–190, 2015.
@article{5834989,
  abstract     = {Flavonoids are a group of polyphenols that provide health-promoting benefits upon consumption. However, poor bioavailability has been a major hurdle in their use as drugs or nutraceuticals. Low bioavailability has been associated with flavonoid interactions at various stages of the digestion, absorption and distribution process, which is strongly affected by their molecular structure. In this review, we use structure–activity/property relationship to discussvariou s flavonoid interactions with food matrices, digestive enzymes, intestinal transporters and blood proteins. This approach reveals specific bioactive properties of flavonoids in the gastrointestinal tract as well as various barriers for their bioavailability. In the last part of this review, we use these insights to determine the effect of different structural characteristics on the overall bioavailability of flavonoids. Such information is crucial when flavonoid or flavonoid derivatives are used as active ingredients in foods or drugs.},
  author       = {Gonzales, Gerard and Smagghe, Guy and Grootaert, Charlotte and Zotti, Moises João and Raes, Katleen and Van Camp, John},
  issn         = {0360-2532},
  journal      = {DRUG METABOLISM REVIEWS},
  keywords     = {ABC transporters,glucuronidation,amylase,flavonoids,lipase,mucus layer,protein-flavonoid interaction,QSAR,sulfation,CANCER RESISTANCE PROTEIN,CACO-2/HT29-MTX COCULTURE MODEL,BOVINE-MILK PROTEINS,P-GLYCOPROTEIN,ALPHA-AMYLASE,INTESTINAL-ABSORPTION,DIETARY POLYPHENOLS,PHENOLIC-COMPOUNDS,DRUG DISCOVERY,AFFINITY RELATIONSHIP},
  language     = {eng},
  number       = {2},
  pages        = {175--190},
  title        = {Flavonoid interactions during digestion, absorption, distribution and metabolism: a sequential structure–activity/property relationship-based approach in the study of bioavailability and bioactivity},
  url          = {http://dx.doi.org/10.3109/03602532.2014.1003649},
  volume       = {47},
  year         = {2015},
}

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