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Neurocognitive development and behaviour in school-aged children after surgery for univentricular or biventricular congenital heart disease

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Abstract
OBJECTIVES: To assess the long-term neuropsychological and behavioural profile of school-aged children who were treated for univentricular heart (UVH) conditions or biventricular heart defect (BiVH) in infancy in a cross-sectional study design. METHODS: Sixty-three patients, 17 UVH (13 males, 4 females) and 46 BiVH (19 males, 27 females), were assessed at a mean age of 9.1 years (2.2 years) with an intelligence and neuropsychological test battery. Results were compared between subgroups (UVH, BiVH and a healthy control group). Associations between cognitive outcome, medical and socio-demographic factors were explored. Parents completed the Child Behavior Checklist (CBCL). RESULTS: Mean intelligence and neuropsychological scores were found within normal ranges for all diagnostic groups. Significant differences between UVH patients and controls emerged on auditory sustained and alternating attention, fine motor skills, visuospatial information processing, and to a lesser extent, memory performance. Parents of UVH patients reported more externalizing problems and school problems. Patient groups did not differ on neuropsychological outcome measures, nor on behavioural problems as rated by parents. CONCLUSIONS: After Fontan completion, patients at school age display intelligence scores within normal population-based ranges. However, they were found at risk for subtle shortcomings in attention, fine motor skills, visuospatial information processing and externalizing behaviour problems. Considerations pertaining to neurobehavioural outcome in school-aged children are discussed.
Keywords
Congenital heart defect, BURDEN, Tricuspid atresia, Neuropsychology, Hypoplastic left heart, Neurodevelopmental outcome, FUNCTIONAL SINGLE VENTRICLE, INFANTS, NEURODEVELOPMENTAL OUTCOMES, ADULTS, LIFE

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Chicago
Sarrechia, Iemke, MARIJKE MIATTON, Daniël De Wolf, Katrien Francois, Marc Gewillig, Bart Meyns, and Guy Vingerhoets. 2016. “Neurocognitive Development and Behaviour in School-aged Children After Surgery for Univentricular or Biventricular Congenital Heart Disease.” European Journal of Cardio-thoracic Surgery 49 (1): 167–174.
APA
Sarrechia, I., MIATTON, M., De Wolf, D., Francois, K., Gewillig, M., Meyns, B., & Vingerhoets, G. (2016). Neurocognitive development and behaviour in school-aged children after surgery for univentricular or biventricular congenital heart disease. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY, 49(1), 167–174.
Vancouver
1.
Sarrechia I, MIATTON M, De Wolf D, Francois K, Gewillig M, Meyns B, et al. Neurocognitive development and behaviour in school-aged children after surgery for univentricular or biventricular congenital heart disease. EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY. 2016;49(1):167–74.
MLA
Sarrechia, Iemke, MARIJKE MIATTON, Daniël De Wolf, et al. “Neurocognitive Development and Behaviour in School-aged Children After Surgery for Univentricular or Biventricular Congenital Heart Disease.” EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY 49.1 (2016): 167–174. Print.
@article{5831768,
  abstract     = {OBJECTIVES: To assess the long-term neuropsychological and behavioural profile of school-aged children who were treated for univentricular heart (UVH) conditions or biventricular heart defect (BiVH) in infancy in a cross-sectional study design. 
METHODS: Sixty-three patients, 17 UVH (13 males, 4 females) and 46 BiVH (19 males, 27 females), were assessed at a mean age of 9.1 years (2.2 years) with an intelligence and neuropsychological test battery. Results were compared between subgroups (UVH, BiVH and a healthy control group). Associations between cognitive outcome, medical and socio-demographic factors were explored. Parents completed the Child Behavior Checklist (CBCL). 
RESULTS: Mean intelligence and neuropsychological scores were found within normal ranges for all diagnostic groups. Significant differences between UVH patients and controls emerged on auditory sustained and alternating attention, fine motor skills, visuospatial information processing, and to a lesser extent, memory performance. Parents of UVH patients reported more externalizing problems and school problems. Patient groups did not differ on neuropsychological outcome measures, nor on behavioural problems as rated by parents. 
CONCLUSIONS: After Fontan completion, patients at school age display intelligence scores within normal population-based ranges. However, they were found at risk for subtle shortcomings in attention, fine motor skills, visuospatial information processing and externalizing behaviour problems. Considerations pertaining to neurobehavioural outcome in school-aged children are discussed.},
  author       = {Sarrechia, Iemke and Miatton, Marijke and De Wolf, Dani{\"e}l and Francois, Katrien and Gewillig, Marc and Meyns, Bart and Vingerhoets, Guy},
  issn         = {1010-7940},
  journal      = {EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY},
  keyword      = {Congenital heart defect,BURDEN,Tricuspid atresia,Neuropsychology,Hypoplastic left heart,Neurodevelopmental outcome,FUNCTIONAL SINGLE VENTRICLE,INFANTS,NEURODEVELOPMENTAL OUTCOMES,ADULTS,LIFE},
  language     = {eng},
  number       = {1},
  pages        = {167--174},
  title        = {Neurocognitive development and behaviour in school-aged children after surgery for univentricular or biventricular congenital heart disease},
  url          = {http://dx.doi.org/10.1093/ejcts/ezv029},
  volume       = {49},
  year         = {2016},
}

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