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Regulation of connexin- and pannexin-based channels by post-translational modifications

(2013) BIOLOGY OF THE CELL. 105(9). p.373-398
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Abstract
Connexin (Cx) and pannexin (Panx) proteins form large conductance channels, which function as regulators of communication between neighbouring cells via gap junctions and/or hemichannels. Intercellular communication is essential to coordinate cellular responses in tissues and organs, thereby fulfilling an essential role in the spreading of signalling, survival and death processes. The functional properties of gap junctions and hemichannels are modulated by different physiological and pathophysiological stimuli. At the molecular level, Cxs and Panxs function as multi-protein channel complexes, regulating their channel localisation and activity. In addition to this, gap junctional channels and hemichannels are modulated by different post-translational modifications (PTMs), including phosphorylation, glycosylation, proteolysis, N-acetylation, S-nitrosylation, ubiquitination, lipidation, hydroxylation, methylation and deamidation. These PTMs influence almost all aspects of communicating junctional channels in normal cell biology and pathophysiology. In this review, we will provide a systematic overview of PTMs of communicating junction proteins and discuss their effects on Cx and Panx-channel activity and localisation.
Keywords
Connexin, Post-translational modification, Pannexin, Gap junctions, Hemichannels, EPSILON-MEDIATED PHOSPHORYLATION, GAP-JUNCTION PROTEIN, HISTONE DEACETYLASE INHIBITORS, CARBOXYL-TERMINAL DOMAIN, CELL-CELL COMMUNICATION, CALHM1 ION-CHANNEL, KINASE-C, PLASMA-MEMBRANE, CARDIAC MYOCYTES, NITRIC-OXIDE

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Citation

Please use this url to cite or link to this publication:

MLA
D’hondt, Catheleyne, et al. “Regulation of Connexin- and Pannexin-Based Channels by Post-Translational Modifications.” BIOLOGY OF THE CELL, vol. 105, no. 9, 2013, pp. 373–98, doi:10.1111/boc.201200096.
APA
D’hondt, C., Iyyathurai, J., Vinken, M., Rogiers, V., Leybaert, L., Himpens, B., & Bultynck, G. (2013). Regulation of connexin- and pannexin-based channels by post-translational modifications. BIOLOGY OF THE CELL, 105(9), 373–398. https://doi.org/10.1111/boc.201200096
Chicago author-date
D’hondt, Catheleyne, Jegan Iyyathurai, Mathieu Vinken, Vera Rogiers, Luc Leybaert, Bernard Himpens, and Geert Bultynck. 2013. “Regulation of Connexin- and Pannexin-Based Channels by Post-Translational Modifications.” BIOLOGY OF THE CELL 105 (9): 373–98. https://doi.org/10.1111/boc.201200096.
Chicago author-date (all authors)
D’hondt, Catheleyne, Jegan Iyyathurai, Mathieu Vinken, Vera Rogiers, Luc Leybaert, Bernard Himpens, and Geert Bultynck. 2013. “Regulation of Connexin- and Pannexin-Based Channels by Post-Translational Modifications.” BIOLOGY OF THE CELL 105 (9): 373–398. doi:10.1111/boc.201200096.
Vancouver
1.
D’hondt C, Iyyathurai J, Vinken M, Rogiers V, Leybaert L, Himpens B, et al. Regulation of connexin- and pannexin-based channels by post-translational modifications. BIOLOGY OF THE CELL. 2013;105(9):373–98.
IEEE
[1]
C. D’hondt et al., “Regulation of connexin- and pannexin-based channels by post-translational modifications,” BIOLOGY OF THE CELL, vol. 105, no. 9, pp. 373–398, 2013.
@article{5829856,
  abstract     = {{Connexin (Cx) and pannexin (Panx) proteins form large conductance channels, which function as regulators of communication between neighbouring cells via gap junctions and/or hemichannels. Intercellular communication is essential to coordinate cellular responses in tissues and organs, thereby fulfilling an essential role in the spreading of signalling, survival and death processes. The functional properties of gap junctions and hemichannels are modulated by different physiological and pathophysiological stimuli. At the molecular level, Cxs and Panxs function as multi-protein channel complexes, regulating their channel localisation and activity. In addition to this, gap junctional channels and hemichannels are modulated by different post-translational modifications (PTMs), including phosphorylation, glycosylation, proteolysis, N-acetylation, S-nitrosylation, ubiquitination, lipidation, hydroxylation, methylation and deamidation. These PTMs influence almost all aspects of communicating junctional channels in normal cell biology and pathophysiology. In this review, we will provide a systematic overview of PTMs of communicating junction proteins and discuss their effects on Cx and Panx-channel activity and localisation.}},
  author       = {{D'hondt, Catheleyne and Iyyathurai, Jegan and Vinken, Mathieu and Rogiers, Vera and Leybaert, Luc and Himpens, Bernard and Bultynck, Geert}},
  issn         = {{0248-4900}},
  journal      = {{BIOLOGY OF THE CELL}},
  keywords     = {{Connexin,Post-translational modification,Pannexin,Gap junctions,Hemichannels,EPSILON-MEDIATED PHOSPHORYLATION,GAP-JUNCTION PROTEIN,HISTONE DEACETYLASE INHIBITORS,CARBOXYL-TERMINAL DOMAIN,CELL-CELL COMMUNICATION,CALHM1 ION-CHANNEL,KINASE-C,PLASMA-MEMBRANE,CARDIAC MYOCYTES,NITRIC-OXIDE}},
  language     = {{eng}},
  number       = {{9}},
  pages        = {{373--398}},
  title        = {{Regulation of connexin- and pannexin-based channels by post-translational modifications}},
  url          = {{http://doi.org/10.1111/boc.201200096}},
  volume       = {{105}},
  year         = {{2013}},
}

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