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Connexin and pannexin (hemi)channels in the liver

Michaël Maes, Elke Decrock UGent, Bruno Cogliati, André G Oliveira, Pedro E Marques, Maria LZ Dagli, Gustavo B Menezes, Gregory Mennecier, Luc Leybaert UGent, Tamara Vanhaecke, et al. (2014) FRONTIERS IN PHYSIOLOGY. 4.
abstract
The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbor connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43. Connexins give rise to hemichannels, which dock with counterparts on adjacent cells to form gap junctions. Both hemichannels and gap junctions provide pathways for communication, via paracrine signaling or direct intercellular coupling, respectively. Over the years, hepatocellular gap junctions have been shown to regulate a number of liver-specific functions and to drive liver cell growth. In the last few years, it has become clear that connexin hemichannels are involved in liver cell death , particularly in hepatocyte apoptosis. This also holds true for hemichannels composed of pannexin1, a connexin-like protein recently identified in the liver. Moreover, pannexin1 hemichannels are key players in the regulation of hepatic inflammatory processes. The current paper provides a concise overview of the features of connexins, pannexins and their channels in the liver.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
pannexin, hemichannel, connexin, gap junction, INDEPENDENT PATHWAY, PARTIAL-HEPATECTOMY, INTERLEUKIN-1-BETA RELEASE, MITOCHONDRIAL CONNEXIN-43, ATP RELEASE, MOUSE-LIVER, RAT-LIVER, INTERCELLULAR COMMUNICATION, FIND-ME SIGNAL, inflammation, GAP-JUNCTION PROTEIN, hepatocyte, cell death
journal title
FRONTIERS IN PHYSIOLOGY
Front. Physiol.
volume
4
article number
405
pages
8 pages
Web of Science type
Review
Web of Science id
000346777200001
JCR category
PHYSIOLOGY
JCR impact factor
3.534 (2014)
JCR rank
20/83 (2014)
JCR quartile
1 (2014)
ISSN
1664-042X
DOI
10.3389/fphys.2013.00405
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
5829651
handle
http://hdl.handle.net/1854/LU-5829651
date created
2015-01-29 09:47:32
date last changed
2017-05-11 14:49:01
@article{5829651,
  abstract     = {The liver was among the first organs in which connexin proteins have been identified. Hepatocytes harbor connexin32 and connexin26, while non-parenchymal liver cells typically express connexin43. Connexins give rise to hemichannels, which dock with counterparts on adjacent cells to form gap junctions. Both hemichannels and gap junctions provide pathways for communication, via paracrine signaling or direct intercellular coupling, respectively. Over the years, hepatocellular gap junctions have been shown to regulate a number of liver-specific functions and to drive liver cell growth. In the last few years, it has become clear that connexin hemichannels are involved in liver cell death , particularly in hepatocyte apoptosis. This also holds true for hemichannels composed of pannexin1, a connexin-like protein recently identified in the liver. Moreover, pannexin1 hemichannels are key players in the regulation of hepatic inflammatory processes. The current paper provides a concise overview of the features of connexins, pannexins and their channels in the liver.},
  articleno    = {405},
  author       = {Maes, Micha{\"e}l and Decrock, Elke and Cogliati, Bruno and Oliveira, Andr{\'e} G and Marques, Pedro E and Dagli, Maria LZ and Menezes, Gustavo B and Mennecier, Gregory and Leybaert, Luc and Vanhaecke, Tamara and Rogiers, Vera and Vinken, Mathieu},
  issn         = {1664-042X},
  journal      = {FRONTIERS IN PHYSIOLOGY},
  keyword      = {pannexin,hemichannel,connexin,gap junction,INDEPENDENT PATHWAY,PARTIAL-HEPATECTOMY,INTERLEUKIN-1-BETA RELEASE,MITOCHONDRIAL CONNEXIN-43,ATP RELEASE,MOUSE-LIVER,RAT-LIVER,INTERCELLULAR COMMUNICATION,FIND-ME SIGNAL,inflammation,GAP-JUNCTION PROTEIN,hepatocyte,cell death},
  language     = {eng},
  pages        = {8},
  title        = {Connexin and pannexin (hemi)channels in the liver},
  url          = {http://dx.doi.org/10.3389/fphys.2013.00405},
  volume       = {4},
  year         = {2014},
}

Chicago
Maes, Michaël, Elke Decrock, Bruno Cogliati, André G Oliveira, Pedro E Marques, Maria LZ Dagli, Gustavo B Menezes, et al. 2014. “Connexin and Pannexin (hemi)channels in the Liver.” Frontiers in Physiology 4.
APA
Maes, Michaël, Decrock, E., Cogliati, B., Oliveira, A. G., Marques, P. E., Dagli, M. L., Menezes, G. B., et al. (2014). Connexin and pannexin (hemi)channels in the liver. FRONTIERS IN PHYSIOLOGY, 4.
Vancouver
1.
Maes M, Decrock E, Cogliati B, Oliveira AG, Marques PE, Dagli ML, et al. Connexin and pannexin (hemi)channels in the liver. FRONTIERS IN PHYSIOLOGY. 2014;4.
MLA
Maes, Michaël, Elke Decrock, Bruno Cogliati, et al. “Connexin and Pannexin (hemi)channels in the Liver.” FRONTIERS IN PHYSIOLOGY 4 (2014): n. pag. Print.