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Prospective non-interventional multicentre observational trial of first-line anti-cancer treatment in patients with metastatic renal cell cancer in Belgium

NATASHA CORNELIS, Tijl Vermassen, D Schallier, J-P Machiels, T Gil, PR Debruyne, R D'hondt, A Bols, D Schrijvers, J Mebis, et al. (2014) ACTA CLINICA BELGICA. 69(5). p.335-340
abstract
Objectives: Renal cell carcinoma (RCC) accounts for 2.4% of all new cancers in Belgium. Over the past decade, the armamentarium for systemic therapy of metastatic RCC (mRCC) has undergone important changes with implementation of targeted therapies directed against pathways involved in the pathogenesis of RCC. We describe first-line treatment choice of a group of patients in 9 Belgian oncology centres between October 2009 and November 2012. Methods: A clinical report form was established to assess patient characteristics, Karnofsky performance score, Memorial Sloan-Kettering Cancer Center risk criteria (MSKCC) and first-line therapy of mRCC patients. Choice of therapy and starting dose was analyzed before and after reimbursement of pazopanib in Belgium. Results: Ninety-six patients were eligible for the study. Non-smokers accounted for 53% of the patients. Seventy-three per cent of the patients had 0 or 1 MSKCC criteria in the group of patients that started treatment more than 1 year after initial diagnosis. In the group of patients that started therapy less than 1 year after diagnosis, 85% had 2 or more MSKCC criteria. This difference was statistically significant (P<0.0001). Overall distribution of the first-line therapies consisted of 43% sunitinib, 33% pazopanib, 14% temsirolimus, 7% everolimus and 3% sorafenib. Seventeen (18%) out of 96 patients started at a reduced dose level. Conclusion: This report shows that the guidelines for the start of first-line treatment in mRCC in 9 centres in Belgium were applied most of the time: a tyrosine kinase inhibitor was the first treatment choice for most patients while temsirolimus was an option for poor prognosis patients. In the majority of patients standard dose levels were initiated, although in some patients adaptation of dosage/treatment schedule was recorded.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
First-line treatment, Metastatic renal cell carcinoma, INTERFERON-ALPHA, PHASE-III, CARCINOMA, INTERLEUKIN-2, PAZOPANIB, SURVIVAL
journal title
ACTA CLINICA BELGICA
Acta Clin. Belg.
volume
69
issue
5
pages
335 - 340
Web of Science type
Article
Web of Science id
000345841600004
JCR category
MEDICINE, GENERAL & INTERNAL
JCR impact factor
0.518 (2014)
JCR rank
125/154 (2014)
JCR quartile
4 (2014)
ISSN
1784-3286
DOI
10.1179/2295333714Y.0000000051
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5822505
handle
http://hdl.handle.net/1854/LU-5822505
date created
2015-01-27 11:43:41
date last changed
2016-12-19 15:42:49
@article{5822505,
  abstract     = {Objectives: Renal cell carcinoma (RCC) accounts for 2.4\% of all new cancers in Belgium. Over the past decade, the armamentarium for systemic therapy of metastatic RCC (mRCC) has undergone important changes with implementation of targeted therapies directed against pathways involved in the pathogenesis of RCC. We describe first-line treatment choice of a group of patients in 9 Belgian oncology centres between October 2009 and November 2012. 
Methods: A clinical report form was established to assess patient characteristics, Karnofsky performance score, Memorial Sloan-Kettering Cancer Center risk criteria (MSKCC) and first-line therapy of mRCC patients. Choice of therapy and starting dose was analyzed before and after reimbursement of pazopanib in Belgium. 
Results: Ninety-six patients were eligible for the study. Non-smokers accounted for 53\% of the patients. Seventy-three per cent of the patients had 0 or 1 MSKCC criteria in the group of patients that started treatment more than 1 year after initial diagnosis. In the group of patients that started therapy less than 1 year after diagnosis, 85\% had 2 or more MSKCC criteria. This difference was statistically significant (P{\textlangle}0.0001). Overall distribution of the first-line therapies consisted of 43\% sunitinib, 33\% pazopanib, 14\% temsirolimus, 7\% everolimus and 3\% sorafenib. Seventeen (18\%) out of 96 patients started at a reduced dose level. 
Conclusion: This report shows that the guidelines for the start of first-line treatment in mRCC in 9 centres in Belgium were applied most of the time: a tyrosine kinase inhibitor was the first treatment choice for most patients while temsirolimus was an option for poor prognosis patients. In the majority of patients standard dose levels were initiated, although in some patients adaptation of dosage/treatment schedule was recorded.},
  author       = {CORNELIS, NATASHA and Vermassen, Tijl and Schallier, D and Machiels, J-P and Gil, T and Debruyne, PR and D'hondt, R and Bols, A and Schrijvers, D and Mebis, J and Lumen, Nicolaas and Rottey, Sylvie},
  issn         = {1784-3286},
  journal      = {ACTA CLINICA BELGICA},
  keyword      = {First-line treatment,Metastatic renal cell carcinoma,INTERFERON-ALPHA,PHASE-III,CARCINOMA,INTERLEUKIN-2,PAZOPANIB,SURVIVAL},
  language     = {eng},
  number       = {5},
  pages        = {335--340},
  title        = {Prospective non-interventional multicentre observational trial of first-line anti-cancer treatment in patients with metastatic renal cell cancer in Belgium},
  url          = {http://dx.doi.org/10.1179/2295333714Y.0000000051},
  volume       = {69},
  year         = {2014},
}

Chicago
CORNELIS, NATASHA, TIJL VERMASSEN, D Schallier, J-P Machiels, T Gil, PR Debruyne, R D’hondt, et al. 2014. “Prospective Non-interventional Multicentre Observational Trial of First-line Anti-cancer Treatment in Patients with Metastatic Renal Cell Cancer in Belgium.” Acta Clinica Belgica 69 (5): 335–340.
APA
CORNELIS, N., VERMASSEN, T., Schallier, D., Machiels, J.-P., Gil, T., Debruyne, P., D’hondt, R., et al. (2014). Prospective non-interventional multicentre observational trial of first-line anti-cancer treatment in patients with metastatic renal cell cancer in Belgium. ACTA CLINICA BELGICA, 69(5), 335–340.
Vancouver
1.
CORNELIS N, VERMASSEN T, Schallier D, Machiels J-P, Gil T, Debruyne P, et al. Prospective non-interventional multicentre observational trial of first-line anti-cancer treatment in patients with metastatic renal cell cancer in Belgium. ACTA CLINICA BELGICA. 2014;69(5):335–40.
MLA
CORNELIS, NATASHA, TIJL VERMASSEN, D Schallier, et al. “Prospective Non-interventional Multicentre Observational Trial of First-line Anti-cancer Treatment in Patients with Metastatic Renal Cell Cancer in Belgium.” ACTA CLINICA BELGICA 69.5 (2014): 335–340. Print.