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Epidemiology of invasive aspergillosis in critically ill patients : clinical presentation, underlying conditions, and outcome

Fabio Silvio Taccone, Anne-Marie Van Den Abeele, Pierre Bulpa, Benoit Misset, Wouter Meersseman, Teresa Cardoso, José-Artur Paiva, Miguel Blasco-Navalpotro, Emmanuel De Laere, George Dimopoulos, et al. (2015) CRITICAL CARE. 19.
abstract
Introduction: Invasive aspergillosis (IA) is a fungal infection that particularly affects immunocompromised hosts. Recently, several studies have indicated a high incidence of IA in intensive care unit (ICU) patients. However, few data are available on the epidemiology and outcome of patients with IA in this setting. Methods: An observational study including all patients with a positive Aspergillus culture during ICU stay was performed in 30 ICUs in 8 countries. Cases were classified as proven IA, putative IA or Aspergillus colonization according to recently validated criteria. Demographic, microbiologic and diagnostic data were collected. Outcome was recorded 12 weeks after Aspergillus isolation. Results: A total of 563 patients were included, of whom 266 were colonized (47%), 203 had putative IA (36%) and 94 had proven IA (17%). The lung was the most frequent site of infection (94%), and Aspergillus fumigatus the most commonly isolated species (92%). Patients with IA had higher incidences of cancer and organ transplantation than those with colonization. Compared with other patients, they were more frequently diagnosed with sepsis on ICU admission and more frequently received vasopressors and renal replacement therapy (RRT) during the ICU stay. Mortality was 38% among colonized patients, 67% in those with putative IA and 79% in those with proven IA (P < 0.001). Independent risk factors for death among patients with IA included older age, history of bone marrow transplantation, and mechanical ventilation, RRT and higher Sequential Organ Failure Assessment score at diagnosis. Conclusions: IA among critically ill patients is associated with high mortality. Patients diagnosed with proven or putative IA had greater severity of illness and more frequently needed organ support than those with Aspergillus spp colonization.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
OBSTRUCTIVE PULMONARY-DISEASE, INTENSIVE-CARE-UNIT, FUNGAL-INFECTIONS, RISK-FACTORS, MOLD INFECTIONS, BRONCHOALVEOLAR LAVAGE, TRANSPLANT RECIPIENTS, RESPIRATORY-TRACT, ICU PATIENTS, MORTALITY
journal title
CRITICAL CARE
Crit. Care
volume
19
article number
7
pages
15 pages
Web of Science type
Article
Web of Science id
000351853300001
JCR category
CRITICAL CARE MEDICINE
JCR impact factor
4.95 (2015)
JCR rank
7/33 (2015)
JCR quartile
1 (2015)
ISSN
1466-609X
DOI
10.1186/s13054-014-0722-7
language
English
UGent publication?
yes
classification
A1
copyright statement
Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
id
5819988
handle
http://hdl.handle.net/1854/LU-5819988
date created
2015-01-27 09:25:17
date last changed
2017-11-13 10:27:07
@article{5819988,
  abstract     = {Introduction: Invasive aspergillosis (IA) is a fungal infection that particularly affects immunocompromised hosts. Recently, several studies have indicated a high incidence of IA in intensive care unit (ICU) patients. However, few data are available on the epidemiology and outcome of patients with IA in this setting. 
Methods: An observational study including all patients with a positive Aspergillus culture during ICU stay was performed in 30 ICUs in 8 countries. Cases were classified as proven IA, putative IA or Aspergillus colonization according to recently validated criteria. Demographic, microbiologic and diagnostic data were collected. Outcome was recorded 12 weeks after Aspergillus isolation. 
Results: A total of 563 patients were included, of whom 266 were colonized (47\%), 203 had putative IA (36\%) and 94 had proven IA (17\%). The lung was the most frequent site of infection (94\%), and Aspergillus fumigatus the most commonly isolated species (92\%). Patients with IA had higher incidences of cancer and organ transplantation than those with colonization. Compared with other patients, they were more frequently diagnosed with sepsis on ICU admission and more frequently received vasopressors and renal replacement therapy (RRT) during the ICU stay. Mortality was 38\% among colonized patients, 67\% in those with putative IA and 79\% in those with proven IA (P {\textlangle} 0.001). Independent risk factors for death among patients with IA included older age, history of bone marrow transplantation, and mechanical ventilation, RRT and higher Sequential Organ Failure Assessment score at diagnosis. 
Conclusions: IA among critically ill patients is associated with high mortality. Patients diagnosed with proven or putative IA had greater severity of illness and more frequently needed organ support than those with Aspergillus spp colonization.},
  articleno    = {7},
  author       = {Taccone, Fabio Silvio and Van Den Abeele, Anne-Marie and Bulpa, Pierre and Misset, Benoit and Meersseman, Wouter and Cardoso, Teresa and Paiva, Jos{\'e}-Artur and Blasco-Navalpotro, Miguel and De Laere, Emmanuel and Dimopoulos, George and Rello, Jordi and Vogelaers, Dirk and Blot, Stijn},
  issn         = {1466-609X},
  journal      = {CRITICAL CARE},
  keyword      = {OBSTRUCTIVE PULMONARY-DISEASE,INTENSIVE-CARE-UNIT,FUNGAL-INFECTIONS,RISK-FACTORS,MOLD INFECTIONS,BRONCHOALVEOLAR LAVAGE,TRANSPLANT RECIPIENTS,RESPIRATORY-TRACT,ICU PATIENTS,MORTALITY},
  language     = {eng},
  pages        = {15},
  title        = {Epidemiology of invasive aspergillosis in critically ill patients : clinical presentation, underlying conditions, and outcome},
  url          = {http://dx.doi.org/10.1186/s13054-014-0722-7},
  volume       = {19},
  year         = {2015},
}

Chicago
Taccone, Fabio Silvio, Anne-Marie Van Den Abeele, Pierre Bulpa, Benoit Misset, Wouter Meersseman, Teresa Cardoso, José-Artur Paiva, et al. 2015. “Epidemiology of Invasive Aspergillosis in Critically Ill Patients : Clinical Presentation, Underlying Conditions, and Outcome.” Critical Care 19.
APA
Taccone, F. S., Van Den Abeele, A.-M., Bulpa, P., Misset, B., Meersseman, W., Cardoso, T., Paiva, J.-A., et al. (2015). Epidemiology of invasive aspergillosis in critically ill patients : clinical presentation, underlying conditions, and outcome. CRITICAL CARE, 19.
Vancouver
1.
Taccone FS, Van Den Abeele A-M, Bulpa P, Misset B, Meersseman W, Cardoso T, et al. Epidemiology of invasive aspergillosis in critically ill patients : clinical presentation, underlying conditions, and outcome. CRITICAL CARE. 2015;19.
MLA
Taccone, Fabio Silvio, Anne-Marie Van Den Abeele, Pierre Bulpa, et al. “Epidemiology of Invasive Aspergillosis in Critically Ill Patients : Clinical Presentation, Underlying Conditions, and Outcome.” CRITICAL CARE 19 (2015): n. pag. Print.