Ghent University Academic Bibliography

Advanced

NOD-like receptors interfacing the immune and reproductive systems

Hanne Van Gorp UGent, Anna Kuchmiy UGent, Filip Van Hauwermeiren and Mohamed Lamkanfi UGent (2014) FEBS JOURNAL. 281(20). p.4568-4582
abstract
Nucleotide-binding oligomerization domain receptors (NOD-like receptors, NLRs) are intracellular proteins that are chiefly known for their critical functions in inflammatory responses and host defense against microbial pathogens. Several NLRs have been demonstrated to assemble inflammasomes or to engage transcriptional signaling cascades that result in the production of pro-inflammatory cytokines and bactericidal factors. In recent years, NLRs have also emerged as key regulators of early mammalian embryogenesis and reproduction. A subset of phylogenetically related NLRs represents a new class of maternal effect genes that are highly expressed in maturing oocytes and pre-implantation embryos. Mutations in several of these NLRs have been linked to hereditary reproductive defects and imprinting diseases. In this review, we discuss the expression profiles, the emerging functions and molecular mode of action of these NLRs with newly recognized roles at the interfaces of the immune and reproductive systems. In addition, we provide an overview of coding mutations in NLRs that have been associated with human reproductive diseases, and outline crucial outstanding questions in this emerging research field.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
PATTERN-RECOGNITION RECEPTORS, PREMATURE OVARIAN FAILURE, BIPARENTAL HYDATIDIFORM MOLES, NF-KAPPA-B, MATERNAL-EFFECT GENE, reproduction, subcortical maternal complex, oocyte, NOD-like receptors, mole, maternal effect gene, inflammasomes, imprinting, embryogenesis, disease, NLRP7 MUTATIONS, MOUSE EMBRYOGENESIS, INTERLEUKIN-1-BETA SECRETION, TRANSLATIONAL CONTROL, EMBRYONIC-DEVELOPMENT
journal title
FEBS JOURNAL
FEBS J.
volume
281
issue
20
pages
4568 - 4582
Web of Science type
Review
Web of Science id
000343918500002
JCR category
BIOCHEMISTRY & MOLECULAR BIOLOGY
JCR impact factor
4.001 (2014)
JCR rank
77/290 (2014)
JCR quartile
2 (2014)
ISSN
1742-464X
DOI
10.1111/febs.13014
language
English
UGent publication?
yes
classification
A1
additional info
the first two authors contributed equally
copyright statement
I have transferred the copyright for this publication to the publisher
id
5809544
handle
http://hdl.handle.net/1854/LU-5809544
date created
2015-01-19 15:04:23
date last changed
2016-12-19 15:46:57
@article{5809544,
  abstract     = {Nucleotide-binding oligomerization domain receptors (NOD-like receptors, NLRs) are intracellular proteins that are chiefly known for their critical functions in inflammatory responses and host defense against microbial pathogens. Several NLRs have been demonstrated to assemble inflammasomes or to engage transcriptional signaling cascades that result in the production of pro-inflammatory cytokines and bactericidal factors. In recent years, NLRs have also emerged as key regulators of early mammalian embryogenesis and reproduction. A subset of phylogenetically related NLRs represents a new class of maternal effect genes that are highly expressed in maturing oocytes and pre-implantation embryos. Mutations in several of these NLRs have been linked to hereditary reproductive defects and imprinting diseases. In this review, we discuss the expression profiles, the emerging functions and molecular mode of action of these NLRs with newly recognized roles at the interfaces of the immune and reproductive systems. In addition, we provide an overview of coding mutations in NLRs that have been associated with human reproductive diseases, and outline crucial outstanding questions in this emerging research field.},
  author       = {Van Gorp, Hanne and Kuchmiy, Anna and Van Hauwermeiren, Filip and Lamkanfi, Mohamed},
  issn         = {1742-464X},
  journal      = {FEBS JOURNAL},
  keyword      = {PATTERN-RECOGNITION RECEPTORS,PREMATURE OVARIAN FAILURE,BIPARENTAL HYDATIDIFORM MOLES,NF-KAPPA-B,MATERNAL-EFFECT GENE,reproduction,subcortical maternal complex,oocyte,NOD-like receptors,mole,maternal effect gene,inflammasomes,imprinting,embryogenesis,disease,NLRP7 MUTATIONS,MOUSE EMBRYOGENESIS,INTERLEUKIN-1-BETA SECRETION,TRANSLATIONAL CONTROL,EMBRYONIC-DEVELOPMENT},
  language     = {eng},
  number       = {20},
  pages        = {4568--4582},
  title        = {NOD-like receptors interfacing the immune and reproductive systems},
  url          = {http://dx.doi.org/10.1111/febs.13014},
  volume       = {281},
  year         = {2014},
}

Chicago
Van Gorp, Hanne, Anna Kuchmiy, Filip Van Hauwermeiren, and Mohamed Lamkanfi. 2014. “NOD-like Receptors Interfacing the Immune and Reproductive Systems.” Febs Journal 281 (20): 4568–4582.
APA
Van Gorp, H., Kuchmiy, A., Van Hauwermeiren, F., & Lamkanfi, M. (2014). NOD-like receptors interfacing the immune and reproductive systems. FEBS JOURNAL, 281(20), 4568–4582.
Vancouver
1.
Van Gorp H, Kuchmiy A, Van Hauwermeiren F, Lamkanfi M. NOD-like receptors interfacing the immune and reproductive systems. FEBS JOURNAL. 2014;281(20):4568–82.
MLA
Van Gorp, Hanne, Anna Kuchmiy, Filip Van Hauwermeiren, et al. “NOD-like Receptors Interfacing the Immune and Reproductive Systems.” FEBS JOURNAL 281.20 (2014): 4568–4582. Print.