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NOD-like receptors interfacing the immune and reproductive systems

(2014) FEBS JOURNAL. 281(20). p.4568-4582
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Abstract
Nucleotide-binding oligomerization domain receptors (NOD-like receptors, NLRs) are intracellular proteins that are chiefly known for their critical functions in inflammatory responses and host defense against microbial pathogens. Several NLRs have been demonstrated to assemble inflammasomes or to engage transcriptional signaling cascades that result in the production of pro-inflammatory cytokines and bactericidal factors. In recent years, NLRs have also emerged as key regulators of early mammalian embryogenesis and reproduction. A subset of phylogenetically related NLRs represents a new class of maternal effect genes that are highly expressed in maturing oocytes and pre-implantation embryos. Mutations in several of these NLRs have been linked to hereditary reproductive defects and imprinting diseases. In this review, we discuss the expression profiles, the emerging functions and molecular mode of action of these NLRs with newly recognized roles at the interfaces of the immune and reproductive systems. In addition, we provide an overview of coding mutations in NLRs that have been associated with human reproductive diseases, and outline crucial outstanding questions in this emerging research field.
Keywords
PATTERN-RECOGNITION RECEPTORS, PREMATURE OVARIAN FAILURE, BIPARENTAL HYDATIDIFORM MOLES, NF-KAPPA-B, MATERNAL-EFFECT GENE, reproduction, subcortical maternal complex, oocyte, NOD-like receptors, mole, maternal effect gene, inflammasomes, imprinting, embryogenesis, disease, NLRP7 MUTATIONS, MOUSE EMBRYOGENESIS, INTERLEUKIN-1-BETA SECRETION, TRANSLATIONAL CONTROL, EMBRYONIC-DEVELOPMENT

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Chicago
Van Gorp, Hanne, Anna Kuchmiy, Filip Van Hauwermeiren, and Mohamed Lamkanfi. 2014. “NOD-like Receptors Interfacing the Immune and Reproductive Systems.” Febs Journal 281 (20): 4568–4582.
APA
Van Gorp, H., Kuchmiy, A., Van Hauwermeiren, F., & Lamkanfi, M. (2014). NOD-like receptors interfacing the immune and reproductive systems. FEBS JOURNAL, 281(20), 4568–4582.
Vancouver
1.
Van Gorp H, Kuchmiy A, Van Hauwermeiren F, Lamkanfi M. NOD-like receptors interfacing the immune and reproductive systems. FEBS JOURNAL. 2014;281(20):4568–82.
MLA
Van Gorp, Hanne, Anna Kuchmiy, Filip Van Hauwermeiren, et al. “NOD-like Receptors Interfacing the Immune and Reproductive Systems.” FEBS JOURNAL 281.20 (2014): 4568–4582. Print.
@article{5809544,
  abstract     = {Nucleotide-binding oligomerization domain receptors (NOD-like receptors, NLRs) are intracellular proteins that are chiefly known for their critical functions in inflammatory responses and host defense against microbial pathogens. Several NLRs have been demonstrated to assemble inflammasomes or to engage transcriptional signaling cascades that result in the production of pro-inflammatory cytokines and bactericidal factors. In recent years, NLRs have also emerged as key regulators of early mammalian embryogenesis and reproduction. A subset of phylogenetically related NLRs represents a new class of maternal effect genes that are highly expressed in maturing oocytes and pre-implantation embryos. Mutations in several of these NLRs have been linked to hereditary reproductive defects and imprinting diseases. In this review, we discuss the expression profiles, the emerging functions and molecular mode of action of these NLRs with newly recognized roles at the interfaces of the immune and reproductive systems. In addition, we provide an overview of coding mutations in NLRs that have been associated with human reproductive diseases, and outline crucial outstanding questions in this emerging research field.},
  author       = {Van Gorp, Hanne and Kuchmiy, Anna and Van Hauwermeiren, Filip and Lamkanfi, Mohamed},
  issn         = {1742-464X},
  journal      = {FEBS JOURNAL},
  keyword      = {PATTERN-RECOGNITION RECEPTORS,PREMATURE OVARIAN FAILURE,BIPARENTAL HYDATIDIFORM MOLES,NF-KAPPA-B,MATERNAL-EFFECT GENE,reproduction,subcortical maternal complex,oocyte,NOD-like receptors,mole,maternal effect gene,inflammasomes,imprinting,embryogenesis,disease,NLRP7 MUTATIONS,MOUSE EMBRYOGENESIS,INTERLEUKIN-1-BETA SECRETION,TRANSLATIONAL CONTROL,EMBRYONIC-DEVELOPMENT},
  language     = {eng},
  number       = {20},
  pages        = {4568--4582},
  title        = {NOD-like receptors interfacing the immune and reproductive systems},
  url          = {http://dx.doi.org/10.1111/febs.13014},
  volume       = {281},
  year         = {2014},
}

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