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Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria

Dieter Demon (UGent) , Lieselotte Vande Walle (UGent) and Mohamed Lamkanfi (UGent)
(2014) TRENDS IN BIOCHEMICAL SCIENCES. 39(12). p.574-576
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Abstract
Caspase-11 contributes to host defense against Gram-negative bacterial pathogens by inducing an inflammatory form of programmed cell death in infected cells. Lipopolysaccharides (LPS) have been identified as the microbial agents that stimulate caspase-11 activation; however, the mechanism of LPS detection has been unknown. In a recent study, Shao and colleagues demonstrate that caspase-11 and its human homologues, caspases -4 and -5, unexpectedly act as direct sensors of cytosolic LPS.
Keywords
ACTIVATION, CASPASE-11, pyroptosis, intracellular lipopolysaccharide, inflammasome, caspase-5, caspase-4, caspase-11, LPS

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Citation

Please use this url to cite or link to this publication:

Chicago
Demon, Dieter, Lieselotte Vande Walle, and Mohamed Lamkanfi. 2014. “Sensing the Enemy Within: How Macrophages Detect Intracellular Gram-negative Bacteria.” Trends in Biochemical Sciences.
APA
Demon, D., Vande Walle, L., & Lamkanfi, M. (2014). Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria. TRENDS IN BIOCHEMICAL SCIENCES.
Vancouver
1.
Demon D, Vande Walle L, Lamkanfi M. Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria. TRENDS IN BIOCHEMICAL SCIENCES. 2014. p. 574–6.
MLA
Demon, Dieter, Lieselotte Vande Walle, and Mohamed Lamkanfi. “Sensing the Enemy Within: How Macrophages Detect Intracellular Gram-negative Bacteria.” TRENDS IN BIOCHEMICAL SCIENCES 2014 : 574–576. Print.
@misc{5809396,
  abstract     = {Caspase-11 contributes to host defense against Gram-negative bacterial pathogens by inducing an inflammatory form of programmed cell death in infected cells. Lipopolysaccharides (LPS) have been identified as the microbial agents that stimulate caspase-11 activation; however, the mechanism of LPS detection has been unknown. In a recent study, Shao and colleagues demonstrate that caspase-11 and its human homologues, caspases -4 and -5, unexpectedly act as direct sensors of cytosolic LPS.},
  author       = {Demon, Dieter and Vande Walle, Lieselotte and Lamkanfi, Mohamed},
  issn         = {0968-0004},
  keyword      = {ACTIVATION,CASPASE-11,pyroptosis,intracellular lipopolysaccharide,inflammasome,caspase-5,caspase-4,caspase-11,LPS},
  language     = {eng},
  number       = {12},
  pages        = {574--576},
  series       = {TRENDS IN BIOCHEMICAL SCIENCES},
  title        = {Sensing the enemy within: how macrophages detect intracellular Gram-negative bacteria},
  url          = {http://dx.doi.org/10.1016/j.tibs.2014.10.006},
  volume       = {39},
  year         = {2014},
}

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