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Effects of tail suspension on serum testosterone and molecular targets regulating muscle mass

Hélène De Naeyer, Séverine Lamon, Aaron P Russell, Inge Everaert UGent, Annelies De Spaey, Cécile Jamart, Bert Vanheel UGent, Youri Taes and Wim Derave UGent (2015) MUSCLE & NERVE. 52(2). p.278-288
abstract
Introduction: The contribution of reduced testosterone levels to tail suspension (TS)-induced muscle atrophy remains equivocal. The molecular mechanism by which testosterone regulates muscle mass during TS has not been investigated. Methods: Effects of TS on serum testosterone levels, muscle mass, and expression of muscle atrophy- and hypertrophy-inducing targets were measured in soleus (SOL) and extensor digitorum longus (EDL) muscles following testosterone administration during 1, 5, and 14 days of TS in male mice. Results: TS produced an increase followed by a transient drop in testosterone levels. Muscle atrophy was associated with downregulation of Igf1 and upregulation of Mstn, Redd1, Atrogin-1, and MuRF1 mRNA with clear differences in Igf1, Mstn, and MAFbx/Atrogin-1 gene expression between SOL and EDL. Testosterone supplementation did not affect muscle mass or protein expression levels during TS. Discussion: The known anabolic effects of testosterone are not sufficient to ameliorate loss of muscle mass during TS
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Testosterone, Tail suspension, Atrogin-1, Disuse atrophy, AKT, MOUSE SKELETAL-MUSCLE, FOXO TRANSCRIPTION FACTORS, MESSENGER-RNA EXPRESSION, GENE-EXPRESSION, HINDLIMB SUSPENSION, UBIQUITIN LIGASES, DISUSE ATROPHY, SIMULATED MICROGRAVITY, MYOSTATIN EXPRESSION, PROTEIN EXPRESSION
journal title
MUSCLE & NERVE
Muscle Nerve
volume
52
issue
2
pages
278 - 288
Web of Science type
Article
Web of Science id
000358379500019
JCR category
CLINICAL NEUROLOGY
JCR impact factor
2.713 (2015)
JCR rank
73/192 (2015)
JCR quartile
2 (2015)
ISSN
0148-639X
DOI
10.1002/mus.24542
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5806927
handle
http://hdl.handle.net/1854/LU-5806927
date created
2015-01-15 11:17:04
date last changed
2016-12-19 15:42:49
@article{5806927,
  abstract     = {Introduction: The contribution of reduced testosterone levels to tail suspension (TS)-induced muscle atrophy remains equivocal. The molecular mechanism by which testosterone regulates muscle mass during TS has not been investigated.
Methods: Effects of TS on serum testosterone levels, muscle mass, and expression of muscle atrophy- and hypertrophy-inducing targets were measured in soleus (SOL) and extensor digitorum longus (EDL) muscles following testosterone administration during 1, 5, and 14 days of TS in male mice.
Results: TS produced an increase followed by a transient drop in testosterone levels. Muscle atrophy was associated with downregulation of Igf1 and upregulation of Mstn, Redd1, Atrogin-1, and MuRF1 mRNA with clear differences in Igf1, Mstn, and MAFbx/Atrogin-1 gene expression between SOL and EDL. Testosterone supplementation did not affect muscle mass or protein expression levels during TS.
Discussion: The known anabolic effects of testosterone are not sufficient to ameliorate loss of muscle mass during TS},
  author       = {De Naeyer, H{\'e}l{\`e}ne and Lamon, S{\'e}verine and Russell, Aaron P and Everaert, Inge and De Spaey, Annelies and Jamart, C{\'e}cile and Vanheel, Bert and Taes, Youri and Derave, Wim},
  issn         = {0148-639X},
  journal      = {MUSCLE \& NERVE},
  keyword      = {Testosterone,Tail suspension,Atrogin-1,Disuse atrophy,AKT,MOUSE SKELETAL-MUSCLE,FOXO TRANSCRIPTION FACTORS,MESSENGER-RNA EXPRESSION,GENE-EXPRESSION,HINDLIMB SUSPENSION,UBIQUITIN LIGASES,DISUSE ATROPHY,SIMULATED MICROGRAVITY,MYOSTATIN EXPRESSION,PROTEIN EXPRESSION},
  language     = {eng},
  number       = {2},
  pages        = {278--288},
  title        = {Effects of tail suspension on serum testosterone and molecular targets regulating muscle mass},
  url          = {http://dx.doi.org/10.1002/mus.24542},
  volume       = {52},
  year         = {2015},
}

Chicago
DE NAEYER, HELENE, Séverine Lamon, Aaron P Russell, Inge Everaert, Annelies De Spaey, Cécile Jamart, Bert Vanheel, Youri Taes, and Wim Derave. 2015. “Effects of Tail Suspension on Serum Testosterone and Molecular Targets Regulating Muscle Mass.” Muscle & Nerve 52 (2): 278–288.
APA
DE NAEYER, H., Lamon, S., Russell, A. P., Everaert, I., De Spaey, A., Jamart, C., Vanheel, B., et al. (2015). Effects of tail suspension on serum testosterone and molecular targets regulating muscle mass. MUSCLE & NERVE, 52(2), 278–288.
Vancouver
1.
DE NAEYER H, Lamon S, Russell AP, Everaert I, De Spaey A, Jamart C, et al. Effects of tail suspension on serum testosterone and molecular targets regulating muscle mass. MUSCLE & NERVE. 2015;52(2):278–88.
MLA
DE NAEYER, HELENE, Séverine Lamon, Aaron P Russell, et al. “Effects of Tail Suspension on Serum Testosterone and Molecular Targets Regulating Muscle Mass.” MUSCLE & NERVE 52.2 (2015): 278–288. Print.