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Event-related potentials reveal preserved attention allocation but impaired emotion regulation in patients with epilepsy and comorbid negative affect

Leen De Taeye (UGent) , Gilles Pourtois (UGent) , Alfred Meurs (UGent) , Paul Boon (UGent) , Kristl Vonck (UGent) , Evelien Carrette (UGent) and Robrecht Raedt (UGent)
(2015) PLOS ONE. 10(1).
Author
Organization
Project
The integrative neuroscience of behavioral control (Neuroscience)
Abstract
Patients with epilepsy have a high prevalence of comorbid mood disorders. This study aims to evaluate whether negative affect in epilepsy is associated with dysfunction of emotion regulation. Event-related potentials (ERPs) are used in order to unravel the exact electrophysiological time course and investigate whether a possible dysfunction arises during early (attention) and/or late (regulation) stages of emotion control. Fifty epileptic patients with (n = 25) versus without (n = 25) comorbid negative affect plus twenty-five matched controls were recruited. ERPs were recorded while subjects performed a face- or house-matching task in which fearful, sad or neutral faces were presented either at attended or unattended spatial locations. Two ERP components were analyzed: the early vertex positive potential (VPP) which is normally enhanced for faces, and the late positive potential (LPP) that is typically larger for emotional stimuli. All participants had larger amplitude of the early face-sensitive VPP for attended faces compared to houses, regardless of their emotional content. By contrast, in patients with negative affect only, the amplitude of the LPP was significantly increased for unattended negative emotional expressions. These VPP results indicate that epilepsy with or without negative affect does not interfere with the early structural encoding and attention selection of faces. However, the LPP results suggest abnormal regulation processes during the processing of unattended emotional faces in patients with epilepsy and comorbid negative affect. In conclusion, this ERP study reveals that early object-based attention processes are not compromised by epilepsy, but instead, when combined with negative affect, this neurological disease is associated with dysfunction during the later stages of emotion regulation. As such, these new neurophysiological findings shed light on the complex interplay of epilepsy with negative affect during the processing of emotional visual stimuli and in turn might help to better understand the etiology and maintenance of mood disorders in epilepsy.
Keywords
negative affect, attention, event-related potentials, epilepsy, emotion, THREAT-RELATED STIMULI, NEURAL MECHANISMS, COGNITIVE-CONTROL, MAJOR DEPRESSION, BRAIN POTENTIALS, ANXIETY, DISORDER, PICTURES, QUALITY-OF-LIFE, FACE

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Citation

Please use this url to cite or link to this publication:

MLA
De Taeye, Leen et al. “Event-related Potentials Reveal Preserved Attention Allocation but Impaired Emotion Regulation in Patients with Epilepsy and Comorbid Negative Affect.” PLOS ONE 10.1 (2015): n. pag. Print.
APA
De Taeye, L., Pourtois, G., Meurs, A., Boon, P., Vonck, K., Carrette, E., & Raedt, R. (2015). Event-related potentials reveal preserved attention allocation but impaired emotion regulation in patients with epilepsy and comorbid negative affect. PLOS ONE, 10(1).
Chicago author-date
De Taeye, Leen, Gilles Pourtois, Alfred Meurs, Paul Boon, Kristl Vonck, Evelien Carrette, and Robrecht Raedt. 2015. “Event-related Potentials Reveal Preserved Attention Allocation but Impaired Emotion Regulation in Patients with Epilepsy and Comorbid Negative Affect.” Plos One 10 (1).
Chicago author-date (all authors)
De Taeye, Leen, Gilles Pourtois, Alfred Meurs, Paul Boon, Kristl Vonck, Evelien Carrette, and Robrecht Raedt. 2015. “Event-related Potentials Reveal Preserved Attention Allocation but Impaired Emotion Regulation in Patients with Epilepsy and Comorbid Negative Affect.” Plos One 10 (1).
Vancouver
1.
De Taeye L, Pourtois G, Meurs A, Boon P, Vonck K, Carrette E, et al. Event-related potentials reveal preserved attention allocation but impaired emotion regulation in patients with epilepsy and comorbid negative affect. PLOS ONE. 2015;10(1).
IEEE
[1]
L. De Taeye et al., “Event-related potentials reveal preserved attention allocation but impaired emotion regulation in patients with epilepsy and comorbid negative affect,” PLOS ONE, vol. 10, no. 1, 2015.
@article{5806711,
  abstract     = {Patients with epilepsy have a high prevalence of comorbid mood disorders. This study aims to evaluate whether negative affect in epilepsy is associated with dysfunction of emotion regulation. Event-related potentials (ERPs) are used in order to unravel the exact electrophysiological time course and investigate whether a possible dysfunction arises during early (attention) and/or late (regulation) stages of emotion control. Fifty epileptic patients with (n = 25) versus without (n = 25) comorbid negative affect plus twenty-five matched controls were recruited. ERPs were recorded while subjects performed a face- or house-matching task in which fearful, sad or neutral faces were presented either at attended or unattended spatial locations. Two ERP components were analyzed: the early vertex positive potential (VPP) which is normally enhanced for faces, and the late positive potential (LPP) that is typically larger for emotional stimuli. All participants had larger amplitude of the early face-sensitive VPP for attended faces compared to houses, regardless of their emotional content. By contrast, in patients with negative affect only, the amplitude of the LPP was significantly increased for unattended negative emotional expressions. These VPP results indicate that epilepsy with or without negative affect does not interfere with the early structural encoding and attention selection of faces. However, the LPP results suggest abnormal regulation processes during the processing of unattended emotional faces in patients with epilepsy and comorbid negative affect. In conclusion, this ERP study reveals that early object-based attention processes are not compromised by epilepsy, but instead, when combined with negative affect, this neurological disease is associated with dysfunction during the later stages of emotion regulation. As such, these new neurophysiological findings shed light on the complex interplay of epilepsy with negative affect during the processing of emotional visual stimuli and in turn might help to better understand the etiology and maintenance of mood disorders in epilepsy.},
  articleno    = {e0116817},
  author       = {De Taeye, Leen and Pourtois, Gilles and Meurs, Alfred and Boon, Paul and Vonck, Kristl and Carrette, Evelien and Raedt, Robrecht},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  keywords     = {negative affect,attention,event-related potentials,epilepsy,emotion,THREAT-RELATED STIMULI,NEURAL MECHANISMS,COGNITIVE-CONTROL,MAJOR DEPRESSION,BRAIN POTENTIALS,ANXIETY,DISORDER,PICTURES,QUALITY-OF-LIFE,FACE},
  language     = {eng},
  number       = {1},
  pages        = {16},
  title        = {Event-related potentials reveal preserved attention allocation but impaired emotion regulation in patients with epilepsy and comorbid negative affect},
  url          = {http://dx.doi.org/10.1371/journal.pone.0116817},
  volume       = {10},
  year         = {2015},
}

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