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Indications, technique, and outcome of therapeutic apheresis in European pediatric nephrology units

(2015) PEDIATRIC NEPHROLOGY. 30(1). p.103-111
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Abstract
Few observations on apheresis in pediatric nephrology units have been published. This retrospective study involved children a parts per thousand currency sign18 years undergoing plasma exchange (PE), immunoadsorption (IA), or double filtration plasmapheresis (DFPP) in 12 European pediatric nephrology units during 2012. Sixty-seven children underwent PE, ten IA, and three DFPP, for a total of 738 PE and 349 IA/DFPP sessions; 67.2 % of PE and 69.2 % of IA/DFPP patients were treated for renal diseases, in particular focal segmental glomerulosclerosis (FSGS), hemolytic-uremic syndrome (HUS), and human leukocyte antigen (HLA) desensitization prior to renal transplantation; 20.9 % of PE and 23.1 % of IA/DFPP patients had neurological diseases. Membrane filtration was the most common technique, albumin the most frequently used substitution fluid, and heparin the preferred anticoagulant. PE achieved full disease remission in 25 patients (37.3 %), partial remission in 22 (32.8 %), and had no effect in 20 (29.9 %). The response to IA/DFPP was complete in seven patients (53.8 %), partial in five (38.5 %), and absent in one (7.7 %). Minor adverse events occurred during 6.9 % of PE and 9.7 % of IA/DFPP sessions. PE, IA, and DFPP are safe apheresis methods in children. Efficacy is high in pediatric patients with recurrent focal segmental glomerulosclerosis (FSGS), atypical hemolytic uremic syndrome (HUS), human leukocyte antigen (HLA) sensitization, and neurological autoimmune diseases.
Keywords
RENAL-TRANSPLANTATION, CHILDREN, PLASMA-EXCHANGE, PLASMAPHERESIS, DIALYSIS, Pediatric apheresis, Therapeutic apheresis, Plasma exchange, Immunoadsorption, Double filtration plasmapheresis, FOCAL SEGMENTAL GLOMERULOSCLEROSIS, COMPLICATIONS, HEMODIALYSIS, EXPERIENCE, REGISTRY

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MLA
Paglialonga, Fabio et al. “Indications, Technique, and Outcome of Therapeutic Apheresis in European Pediatric Nephrology Units.” PEDIATRIC NEPHROLOGY 30.1 (2015): 103–111. Print.
APA
Paglialonga, F., Schmitt, C. P., Shroff, R., Vondrak, K., Aufricht, C., Watson, A. R., Ariceta, G., et al. (2015). Indications, technique, and outcome of therapeutic apheresis in European pediatric nephrology units. PEDIATRIC NEPHROLOGY, 30(1), 103–111.
Chicago author-date
Paglialonga, Fabio, Claus Peter Schmitt, Rukshana Shroff, Karel Vondrak, Christoph Aufricht, Alan Rees Watson, Gema Ariceta, et al. 2015. “Indications, Technique, and Outcome of Therapeutic Apheresis in European Pediatric Nephrology Units.” Pediatric Nephrology 30 (1): 103–111.
Chicago author-date (all authors)
Paglialonga, Fabio, Claus Peter Schmitt, Rukshana Shroff, Karel Vondrak, Christoph Aufricht, Alan Rees Watson, Gema Ariceta, Michael Fischbach, Gunter Klaus, Tuula Holtta, Sevcan A Bakkaloglu, Alexandra Zurowska, Augustina Jankauskiene, Johan Vande Walle, Betti Schaefer, Elizabeth Wright, Roy Connell, and Alberto Edefonti. 2015. “Indications, Technique, and Outcome of Therapeutic Apheresis in European Pediatric Nephrology Units.” Pediatric Nephrology 30 (1): 103–111.
Vancouver
1.
Paglialonga F, Schmitt CP, Shroff R, Vondrak K, Aufricht C, Watson AR, et al. Indications, technique, and outcome of therapeutic apheresis in European pediatric nephrology units. PEDIATRIC NEPHROLOGY. 2015;30(1):103–11.
IEEE
[1]
F. Paglialonga et al., “Indications, technique, and outcome of therapeutic apheresis in European pediatric nephrology units,” PEDIATRIC NEPHROLOGY, vol. 30, no. 1, pp. 103–111, 2015.
@article{5804434,
  abstract     = {Few observations on apheresis in pediatric nephrology units have been published. 
This retrospective study involved children a parts per thousand currency sign18 years undergoing plasma exchange (PE), immunoadsorption (IA), or double filtration plasmapheresis (DFPP) in 12 European pediatric nephrology units during 2012. 
Sixty-seven children underwent PE, ten IA, and three DFPP, for a total of 738 PE and 349 IA/DFPP sessions; 67.2 % of PE and 69.2 % of IA/DFPP patients were treated for renal diseases, in particular focal segmental glomerulosclerosis (FSGS), hemolytic-uremic syndrome (HUS), and human leukocyte antigen (HLA) desensitization prior to renal transplantation; 20.9 % of PE and 23.1 % of IA/DFPP patients had neurological diseases. Membrane filtration was the most common technique, albumin the most frequently used substitution fluid, and heparin the preferred anticoagulant. PE achieved full disease remission in 25 patients (37.3 %), partial remission in 22 (32.8 %), and had no effect in 20 (29.9 %). The response to IA/DFPP was complete in seven patients (53.8 %), partial in five (38.5 %), and absent in one (7.7 %). Minor adverse events occurred during 6.9 % of PE and 9.7 % of IA/DFPP sessions. 
PE, IA, and DFPP are safe apheresis methods in children. Efficacy is high in pediatric patients with recurrent focal segmental glomerulosclerosis (FSGS), atypical hemolytic uremic syndrome (HUS), human leukocyte antigen (HLA) sensitization, and neurological autoimmune diseases.},
  author       = {Paglialonga, Fabio and Schmitt, Claus Peter and Shroff, Rukshana and Vondrak, Karel and Aufricht, Christoph and Watson, Alan Rees and Ariceta, Gema and Fischbach, Michael and Klaus, Gunter and Holtta, Tuula and Bakkaloglu, Sevcan A and Zurowska, Alexandra and Jankauskiene, Augustina and Vande Walle, Johan and Schaefer, Betti and Wright, Elizabeth and Connell, Roy and Edefonti, Alberto},
  issn         = {0931-041X},
  journal      = {PEDIATRIC NEPHROLOGY},
  keywords     = {RENAL-TRANSPLANTATION,CHILDREN,PLASMA-EXCHANGE,PLASMAPHERESIS,DIALYSIS,Pediatric apheresis,Therapeutic apheresis,Plasma exchange,Immunoadsorption,Double filtration plasmapheresis,FOCAL SEGMENTAL GLOMERULOSCLEROSIS,COMPLICATIONS,HEMODIALYSIS,EXPERIENCE,REGISTRY},
  language     = {eng},
  number       = {1},
  pages        = {103--111},
  title        = {Indications, technique, and outcome of therapeutic apheresis in European pediatric nephrology units},
  url          = {http://dx.doi.org/10.1007/s00467-014-2907-3},
  volume       = {30},
  year         = {2015},
}

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