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Biosurfactant gene clusters in eukaryotes: regulation and biotechnological potential

Sophie Roelants (UGent) , Sofie De Maeseneire (UGent) , Katarzyna Ciesielska (UGent) , Inge Van Bogaert (UGent) and Wim Soetaert (UGent)
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Abstract
Biosurfactants (BSs) are a class of secondary metabolites representing a wide variety of structures that can be produced from renewable feedstock by a wide variety of micro-organisms. They have (potential) applications in the medical world, personal care sector, mining processes, food industry, cosmetics, crop protection, pharmaceuticals, bio-remediation, household detergents, paper and pulp industry, textiles, paint industries, etc. Especially glycolipid BSs like sophorolipids (SLs), rhamnolipids (RLs), mannosylerythritol lipids (MELs) and cellobioselipids (CBLs) have been described to provide significant opportunities to (partially) replace chemical surfactants. The major two factors currently limiting the penetration of BSs into the market are firstly the limited structural variety and secondly the rather high production price linked with the productivity. One of the keys to resolve the abovementioned bottlenecks can be found in the genetic engineering of natural producers. This could not only result in more efficient (economical) recombinant producers, but also in a diversification of the spectrum of available BSs as such resolving both limiting factors at once. Unraveling the genetics behind the biosynthesis of these interesting biological compounds is indispensable for the tinkering, fine tuning and rearrangement of these biological pathways with the aim of obtaining higher yields and a more extensive structural variety. Therefore, this review focuses on recent developments in the investigation of the biosynthesis, genetics and regulation of some important members of the family of the eukaryotic glycolipid BSs (MELs, CBLs and SLs). Moreover, recent biotechnological achievements and the industrial potential of engineered strains are discussed.
Keywords
Clusters, Secondary metabolites, Biosurfactants, BASIDIOMYCETOUS YEAST, ANTIFUNGAL ACTIVITY, GLYCOLIPID BIOSURFACTANTS, MANNOSYLERYTHRITOL LIPIDS, Biotechnology, FUNGUS USTILAGO-MAYDIS, SOPHOROSE LIPID PRODUCTION, Eukaryotes, CANDIDA TORULOPSIS APICOLA, Regulation, BOMBICOLA ATCC 22214, STARMERELLA-BOMBICOLA, YEAST PSEUDOZYMA-ANTARCTICA

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MLA
Roelants, Sophie, Sofie De Maeseneire, Katarzyna Ciesielska, et al. “Biosurfactant Gene Clusters in Eukaryotes: Regulation and Biotechnological Potential.” APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 98.8 (2014): 3449–3461. Print.
APA
Roelants, S., De Maeseneire, S., Ciesielska, K., Van Bogaert, I., & Soetaert, W. (2014). Biosurfactant gene clusters in eukaryotes: regulation and biotechnological potential. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, 98(8), 3449–3461.
Chicago author-date
Roelants, Sophie, Sofie De Maeseneire, Katarzyna Ciesielska, Inge Van Bogaert, and Wim Soetaert. 2014. “Biosurfactant Gene Clusters in Eukaryotes: Regulation and Biotechnological Potential.” Applied Microbiology and Biotechnology 98 (8): 3449–3461.
Chicago author-date (all authors)
Roelants, Sophie, Sofie De Maeseneire, Katarzyna Ciesielska, Inge Van Bogaert, and Wim Soetaert. 2014. “Biosurfactant Gene Clusters in Eukaryotes: Regulation and Biotechnological Potential.” Applied Microbiology and Biotechnology 98 (8): 3449–3461.
Vancouver
1.
Roelants S, De Maeseneire S, Ciesielska K, Van Bogaert I, Soetaert W. Biosurfactant gene clusters in eukaryotes: regulation and biotechnological potential. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY. 2014;98(8):3449–61.
IEEE
[1]
S. Roelants, S. De Maeseneire, K. Ciesielska, I. Van Bogaert, and W. Soetaert, “Biosurfactant gene clusters in eukaryotes: regulation and biotechnological potential,” APPLIED MICROBIOLOGY AND BIOTECHNOLOGY, vol. 98, no. 8, pp. 3449–3461, 2014.
@article{5803429,
  abstract     = {Biosurfactants (BSs) are a class of secondary metabolites representing a wide variety of structures that can be produced from renewable feedstock by a wide variety of micro-organisms. They have (potential) applications in the medical world, personal care sector, mining processes, food industry, cosmetics, crop protection, pharmaceuticals, bio-remediation, household detergents, paper and pulp industry, textiles, paint industries, etc. Especially glycolipid BSs like sophorolipids (SLs), rhamnolipids (RLs), mannosylerythritol lipids (MELs) and cellobioselipids (CBLs) have been described to provide significant opportunities to (partially) replace chemical surfactants. The major two factors currently limiting the penetration of BSs into the market are firstly the limited structural variety and secondly the rather high production price linked with the productivity. One of the keys to resolve the abovementioned bottlenecks can be found in the genetic engineering of natural producers. This could not only result in more efficient (economical) recombinant producers, but also in a diversification of the spectrum of available BSs as such resolving both limiting factors at once. Unraveling the genetics behind the biosynthesis of these interesting biological compounds is indispensable for the tinkering, fine tuning and rearrangement of these biological pathways with the aim of obtaining higher yields and a more extensive structural variety. Therefore, this review focuses on recent developments in the investigation of the biosynthesis, genetics and regulation of some important members of the family of the eukaryotic glycolipid BSs (MELs, CBLs and SLs). Moreover, recent biotechnological achievements and the industrial potential of engineered strains are discussed.},
  author       = {Roelants, Sophie and De Maeseneire, Sofie and Ciesielska, Katarzyna and Van Bogaert, Inge and Soetaert, Wim},
  issn         = {0175-7598},
  journal      = {APPLIED MICROBIOLOGY AND BIOTECHNOLOGY},
  keywords     = {Clusters,Secondary metabolites,Biosurfactants,BASIDIOMYCETOUS YEAST,ANTIFUNGAL ACTIVITY,GLYCOLIPID BIOSURFACTANTS,MANNOSYLERYTHRITOL LIPIDS,Biotechnology,FUNGUS USTILAGO-MAYDIS,SOPHOROSE LIPID PRODUCTION,Eukaryotes,CANDIDA TORULOPSIS APICOLA,Regulation,BOMBICOLA ATCC 22214,STARMERELLA-BOMBICOLA,YEAST PSEUDOZYMA-ANTARCTICA},
  language     = {eng},
  number       = {8},
  pages        = {3449--3461},
  title        = {Biosurfactant gene clusters in eukaryotes: regulation and biotechnological potential},
  url          = {http://dx.doi.org/10.1007/s00253-014-5547-4},
  volume       = {98},
  year         = {2014},
}

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