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A proteome-scale map of the human interactome network

(2014) CELL. 159(5). p.1212-1226
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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand geno-type- phenotype relationships. Here, we describe a systematic map of similar to 14,000 high-quality human binary protein-protein interactions. At equal quality, this map is similar to 30% larger than what is available from small-scale studies published in the literature in the last few decades. While currently available information is highly biased and only covers a relatively small portion of the proteome, our systematic map appears strikingly more homogeneous, revealing a "broader'' human interactome network than currently appreciated. The map also uncovers significant inter-connectivity between known and candidate cancer gene products, providing unbiased evidence for an expanded functional cancer landscape, while demonstrating how high-quality interactome models will help "connect the dots'' of the genomic revolution.
Keywords
PROTEINS, DISORDERS, GENOME-WIDE ASSOCIATION, MOLECULAR INTERACTION DATABASE, POSTTRANSLATIONAL MODIFICATIONS, HUMAN-DISEASE, COMPREHENSIVE RESOURCE, CANCER GENES, EXPRESSION, UPDATE

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Citation

Please use this url to cite or link to this publication:

Chicago
Rolland, Thomas, Murat Taşan, Benoit Charloteaux, Samuel J Pevzner, Quan Zhong, Nidhi Sahni, Song Yi, et al. 2014. “A Proteome-scale Map of the Human Interactome Network.” Cell 159 (5): 1212–1226.
APA
Rolland, T., Taşan, M., Charloteaux, B., Pevzner, S. J., Zhong, Q., Sahni, N., Yi, S., et al. (2014). A proteome-scale map of the human interactome network. CELL, 159(5), 1212–1226.
Vancouver
1.
Rolland T, Taşan M, Charloteaux B, Pevzner SJ, Zhong Q, Sahni N, et al. A proteome-scale map of the human interactome network. CELL. 2014;159(5):1212–26.
MLA
Rolland, Thomas, Murat Taşan, Benoit Charloteaux, et al. “A Proteome-scale Map of the Human Interactome Network.” CELL 159.5 (2014): 1212–1226. Print.
@article{5801043,
  abstract     = {Just as reference genome sequences revolutionized human genetics, reference maps of interactome networks will be critical to fully understand geno-type- phenotype relationships. Here, we describe a systematic map of similar to 14,000 high-quality human binary protein-protein interactions. At equal quality, this map is similar to 30\% larger than what is available from small-scale studies published in the literature in the last few decades. While currently available information is highly biased and only covers a relatively small portion of the proteome, our systematic map appears strikingly more homogeneous, revealing a {\textacutedbl}broader'' human interactome network than currently appreciated. The map also uncovers significant inter-connectivity between known and candidate cancer gene products, providing unbiased evidence for an expanded functional cancer landscape, while demonstrating how high-quality interactome models will help {\textacutedbl}connect the dots'' of the genomic revolution.},
  author       = {Rolland, Thomas and Ta\c{s}an, Murat and Charloteaux, Benoit and Pevzner, Samuel J and Zhong, Quan and Sahni, Nidhi and Yi, Song and Lemmens, Irma and Fontanillo, Celia and Mosca, Roberto and Kamburov, Atanas and Ghiassian, Susan D and Yang, Xinping and Ghamsari, Lila and Balcha, Dawit and Begg, Bridget E and Braun, Pascal and Brehme, Marc and Broly, Martin P and Carvunis, Anne-Ruxandra and Convery-Zupan, Dan and Corominas, Roser and Coulombe-Huntington, Jasmin and Dann, Elizabeth and Dreze, Matija and Dricot, Am{\'e}lie and Fan, Changyu and Franzosa, Eric and Gebreab, Fana and Gutierrez, Bryan J and Hardy, Madeleine F and Jin, Mike and Kang, Shuli and Kiros, Ruth and Lin, Guan Ning and Luck, Katja and MacWilliams, Andrew and Menche, J{\"o}rg and Murray, Ryan R and Palagi, Alexandre and Poulin, Matthew M and Rambout, Xavier and Rasla, John and Reichert, Patrick and Romero, Viviana and Ruyssinck, Elien and Sahalie, Julie M and Scholz, Annemarie and Shah, Akash A and Sharma, Amitabh and Shen, Yun and Spirohn, Kerstin and Tam, Stanley and Tejeda, Alexander O and Trigg, Shelley A and Twizere, Jean-Claude and Vega, Kerwin and Walsh, Jennifer and Cusick, Michael E and Xia, Yu and Barab{\'a}si, Albert-L{\'a}szl{\'o} and Iakoucheva, Lilia M and Aloy, Patrick and De Las Rivas, Javier and Tavernier, Jan and Calderwood, Michael A and Hill, David E and Hao, Tong and Roth, Frederick P and Vidal, Marc},
  issn         = {0092-8674},
  journal      = {CELL},
  keyword      = {PROTEINS,DISORDERS,GENOME-WIDE ASSOCIATION,MOLECULAR INTERACTION DATABASE,POSTTRANSLATIONAL MODIFICATIONS,HUMAN-DISEASE,COMPREHENSIVE RESOURCE,CANCER GENES,EXPRESSION,UPDATE},
  language     = {eng},
  number       = {5},
  pages        = {1212--1226},
  title        = {A proteome-scale map of the human interactome network},
  url          = {http://dx.doi.org/10.1016/j.cell.2014.10.050},
  volume       = {159},
  year         = {2014},
}

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