Advanced search
1 file | 1.80 MB

Influence of valve size, orientation and downstream geometry of an aortic BMHV on leaflet motion and clinically used valve performance parameters

Sebastiaan Annerel (UGent) , Tom Claessens (UGent) , Liesbeth Taelman (UGent) , Joris Degroote (UGent) , Guido Van Nooten (UGent) , Pascal Verdonck (UGent) , Patrick Segers (UGent) and Jan Vierendeels (UGent)
(2015) ANNALS OF BIOMEDICAL ENGINEERING. 43(6). p.1370-1384
Author
Organization
Abstract
The aim of this study was to reconcile some of our own previous work and the work of others to generate a physiologically realistic numerical simulation environment that allows to virtually assess the performance of BMHVs. The model incorporates: (i) a left ventricular deformable model to generate a physiological inflow to the aortic valve; (ii) a patient-specific aortic geometry (root, arch and descending aorta); (iii) physiological pressure and flow boundary conditions. We particularly studied the influence of downstream geometry, valve size and orientation on leaflet kinematics and functional indices used in clinical routine. Compared to the straight tube geometry, the patient-specific aorta leads to a significant asynchronous movement of the valve, especially during the closing of the valve. The anterior leaflet starts to close first, impacts the casing at the closed position and remains in this position. At the same time, the posterior leaflet impacts the pivoting mechanisms at the fully open position. At the end of systole, this leaflet subsequently accelerates to the closed position, impacting the casing with an angular velocity of approximately -477 rad/s. The valve size greatly influences the transvalvular pressure gradient (TPG), but does not change the overall leaflet kinematics. This is in contrast to changes in valve orientation, where changing valve orientation induces large differences in leaflet kinematics, but the TPG remains approximately the same.
Keywords
DOPPLER-ECHOCARDIOGRAPHY, PROSTHETIC HEART-VALVE, SIMULATION, DYNAMICS, CAVITATION, ULTRASOUND, VOLUME, FLOW, Aortic BMHV, Size, Orientation, Pressure gradient, Effective orifice area, Performance index, Regurgitation, Carbomedics

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.80 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Annerel, Sebastiaan, Tom Claessens, Liesbeth Taelman, Joris Degroote, Guido Van Nooten, Pascal Verdonck, Patrick Segers, and Jan Vierendeels. 2015. “Influence of Valve Size, Orientation and Downstream Geometry of an Aortic BMHV on Leaflet Motion and Clinically Used Valve Performance Parameters.” Annals of Biomedical Engineering 43 (6): 1370–1384.
APA
Annerel, S., Claessens, T., Taelman, L., Degroote, J., Van Nooten, G., Verdonck, P., Segers, P., et al. (2015). Influence of valve size, orientation and downstream geometry of an aortic BMHV on leaflet motion and clinically used valve performance parameters. ANNALS OF BIOMEDICAL ENGINEERING, 43(6), 1370–1384.
Vancouver
1.
Annerel S, Claessens T, Taelman L, Degroote J, Van Nooten G, Verdonck P, et al. Influence of valve size, orientation and downstream geometry of an aortic BMHV on leaflet motion and clinically used valve performance parameters. ANNALS OF BIOMEDICAL ENGINEERING. 2015;43(6):1370–84.
MLA
Annerel, Sebastiaan, Tom Claessens, Liesbeth Taelman, et al. “Influence of Valve Size, Orientation and Downstream Geometry of an Aortic BMHV on Leaflet Motion and Clinically Used Valve Performance Parameters.” ANNALS OF BIOMEDICAL ENGINEERING 43.6 (2015): 1370–1384. Print.
@article{5800811,
  abstract     = {The aim of this study was to reconcile some of our own previous work and the work of others to generate a physiologically realistic numerical simulation environment that allows to virtually assess the performance of BMHVs. The model incorporates: (i) a left ventricular deformable model to generate a physiological inflow to the aortic valve; (ii) a patient-specific aortic geometry (root, arch and descending aorta); (iii) physiological pressure and flow boundary conditions. We particularly studied the influence of downstream geometry, valve size and orientation on leaflet kinematics and functional indices used in clinical routine. Compared to the straight tube geometry, the patient-specific aorta leads to a significant asynchronous movement of the valve, especially during the closing of the valve. The anterior leaflet starts to close first, impacts the casing at the closed position and remains in this position. At the same time, the posterior leaflet impacts the pivoting mechanisms at the fully open position. At the end of systole, this leaflet subsequently accelerates to the closed position, impacting the casing with an angular velocity of approximately -477 rad/s. The valve size greatly influences the transvalvular pressure gradient (TPG), but does not change the overall leaflet kinematics. This is in contrast to changes in valve orientation, where changing valve orientation induces large differences in leaflet kinematics, but the TPG remains approximately the same.},
  author       = {Annerel, Sebastiaan and Claessens, Tom and Taelman, Liesbeth and Degroote, Joris and Van Nooten, Guido and Verdonck, Pascal and Segers, Patrick and Vierendeels, Jan},
  issn         = {0090-6964},
  journal      = {ANNALS OF BIOMEDICAL ENGINEERING},
  keyword      = {DOPPLER-ECHOCARDIOGRAPHY,PROSTHETIC HEART-VALVE,SIMULATION,DYNAMICS,CAVITATION,ULTRASOUND,VOLUME,FLOW,Aortic BMHV,Size,Orientation,Pressure gradient,Effective orifice area,Performance index,Regurgitation,Carbomedics},
  language     = {eng},
  number       = {6},
  pages        = {1370--1384},
  title        = {Influence of valve size, orientation and downstream geometry of an aortic BMHV on leaflet motion and clinically used valve performance parameters},
  url          = {http://dx.doi.org/10.1007/s10439-014-1102-9},
  volume       = {43},
  year         = {2015},
}

Altmetric
View in Altmetric
Web of Science
Times cited: