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Heat-shock proteins in stromal joint tissues: innocent bystanders or disease-initiating proteins?

Stijn Lambrecht (UGent) , Nele Juchtmans (UGent) and Dirk Elewaut (UGent)
(2014) RHEUMATOLOGY. 53(2). p.223-232
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Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
Abstract
Heat-shock proteins (HSPs) are molecular chaperones that are highly conserved between species. In recent decades it has become clear that these proteins play an important role in the pathogenesis of inflammatory and degenerative joint diseases by (dys)regulating the immune system and by direct effects on the stromal tissues of the joint. In this review we discuss current insights into the expression pattern of HSPs in connective tissues, the direct biological role of HSPs in stromal tissues and the potential clinical applications.
Keywords
osteoarthritis, tissue inflammation, arthritis, stress response, connective, JUVENILE IDIOPATHIC ARTHRITIS, ALPHA-B-CRYSTALLIN, EPITOPE-SPECIFIC IMMUNOTHERAPY, SYSTEMIC-LUPUS-ERYTHEMATOSUS, FIBROBLAST-LIKE SYNOVIOCYTES, COLLAGEN-INDUCED ARTHRITIS, MOLECULAR CHAPERONE HSP47, DENDRITIC CELL MATURATION, OXIDE-INDUCED APOPTOSIS, RHEUMATOID-ARTHRITIS

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Citation

Please use this url to cite or link to this publication:

Chicago
Lambrecht, Stijn, Nele Juchtmans, and Dirk Elewaut. 2014. “Heat-shock Proteins in Stromal Joint Tissues: Innocent Bystanders or Disease-initiating Proteins?” Rheumatology 53 (2): 223–232.
APA
Lambrecht, Stijn, Juchtmans, N., & Elewaut, D. (2014). Heat-shock proteins in stromal joint tissues: innocent bystanders or disease-initiating proteins? RHEUMATOLOGY, 53(2), 223–232.
Vancouver
1.
Lambrecht S, Juchtmans N, Elewaut D. Heat-shock proteins in stromal joint tissues: innocent bystanders or disease-initiating proteins? RHEUMATOLOGY. 2014;53(2):223–32.
MLA
Lambrecht, Stijn, Nele Juchtmans, and Dirk Elewaut. “Heat-shock Proteins in Stromal Joint Tissues: Innocent Bystanders or Disease-initiating Proteins?” RHEUMATOLOGY 53.2 (2014): 223–232. Print.
@article{5800460,
  abstract     = {Heat-shock proteins (HSPs) are molecular chaperones that are highly conserved between species. In recent decades it has become clear that these proteins play an important role in the pathogenesis of inflammatory and degenerative joint diseases by (dys)regulating the immune system and by direct effects on the stromal tissues of the joint. In this review we discuss current insights into the expression pattern of HSPs in connective tissues, the direct biological role of HSPs in stromal tissues and the potential clinical applications.},
  author       = {Lambrecht, Stijn and Juchtmans, Nele and Elewaut, Dirk},
  issn         = {1462-0324},
  journal      = {RHEUMATOLOGY},
  keywords     = {osteoarthritis,tissue inflammation,arthritis,stress response,connective,JUVENILE IDIOPATHIC ARTHRITIS,ALPHA-B-CRYSTALLIN,EPITOPE-SPECIFIC IMMUNOTHERAPY,SYSTEMIC-LUPUS-ERYTHEMATOSUS,FIBROBLAST-LIKE SYNOVIOCYTES,COLLAGEN-INDUCED ARTHRITIS,MOLECULAR CHAPERONE HSP47,DENDRITIC CELL MATURATION,OXIDE-INDUCED APOPTOSIS,RHEUMATOID-ARTHRITIS},
  language     = {eng},
  number       = {2},
  pages        = {223--232},
  title        = {Heat-shock proteins in stromal joint tissues: innocent bystanders or disease-initiating proteins?},
  url          = {http://dx.doi.org/10.1093/rheumatology/ket277},
  volume       = {53},
  year         = {2014},
}

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