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Changes in oxidative stress in response to different levels of energy restriction in obese ponies

(2014) BRITISH JOURNAL OF NUTRITION. 112(8). p.1402-1411
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Abstract
The present study evaluated the effect of different levels of energy restriction on metabolic parameters in obese ponies. Relative weight changes, markers of lipid metabolism, and oxidant/antioxidant balance were monitored. Eighteen obese (body condition score≥7/9) Shetland ponies were studied over a 23.5 week trial, divided into 3 periods. First a 4 week adaptation period in which each animal was fed 100% of their maintenance energy requirements needed to maintain stable obese body weight (MERob). Then a 16.5 weeks weight loss period in which ponies were assigned to receive either 100% (control group, CONTROL), 80% (slow weight loss group, SLOW) or 60% (rapid weight loss group, RAPID) of their MERob. During the 3 week end phase period all animals were again fed 100% of their MERob. Relative weight loss was higher in RAPID (P<0.001) compared to SLOW. No linear relationship was found as a doubling in caloric restriction was accompanied with a tripling in weight loss. Relative weight gain afterwards in the end phase period was higher in RAPID (P<0.001) compared to SLOW and CONTROL. During the weight loss period, triacylglycerol and non-esterified fatty acids levels were highest in RAPID, as were α-tocopherol and ferric reducing ability of plasma. After 8 weeks of weight loss, advanced oxidation protein products were higher in RAPID compared to SLOW and CONTROL (P<0.001). In conclusion, the level of energy restriction influences the extent of changes in oxidant/antioxidant balance. Practically, more severe energy restriction regimens may be associated with a greater regain of weight post restriction.
Keywords
Energy restriction, Ponies, Weight-loss rate, Oxidative stress, WEIGHT-LOSS, ADVANCED GLYCATION, INSULIN SENSITIVITY, DIETARY RESTRICTION, LIPID-PEROXIDATION, METABOLIC SYNDROME, END-PRODUCTS, HORSES, PLASMA, ANTIOXIDANTS

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MLA
Bruynsteen, Lien et al. “Changes in Oxidative Stress in Response to Different Levels of Energy Restriction in Obese Ponies.” BRITISH JOURNAL OF NUTRITION 112.8 (2014): 1402–1411. Print.
APA
Bruynsteen, L., Janssens, G., Harris, P. A., Duchateau, L., Valle, E., Odetti, P., Vandevelde, K., et al. (2014). Changes in oxidative stress in response to different levels of energy restriction in obese ponies. BRITISH JOURNAL OF NUTRITION, 112(8), 1402–1411.
Chicago author-date
Bruynsteen, Lien, Geert Janssens, Patricia A Harris, Luc Duchateau, Emanuela Valle, Patrizio Odetti, Kimberley Vandevelde, Johan Buyse, and Myriam Hesta. 2014. “Changes in Oxidative Stress in Response to Different Levels of Energy Restriction in Obese Ponies.” British Journal of Nutrition 112 (8): 1402–1411.
Chicago author-date (all authors)
Bruynsteen, Lien, Geert Janssens, Patricia A Harris, Luc Duchateau, Emanuela Valle, Patrizio Odetti, Kimberley Vandevelde, Johan Buyse, and Myriam Hesta. 2014. “Changes in Oxidative Stress in Response to Different Levels of Energy Restriction in Obese Ponies.” British Journal of Nutrition 112 (8): 1402–1411.
Vancouver
1.
Bruynsteen L, Janssens G, Harris PA, Duchateau L, Valle E, Odetti P, et al. Changes in oxidative stress in response to different levels of energy restriction in obese ponies. BRITISH JOURNAL OF NUTRITION. 2014;112(8):1402–11.
IEEE
[1]
L. Bruynsteen et al., “Changes in oxidative stress in response to different levels of energy restriction in obese ponies,” BRITISH JOURNAL OF NUTRITION, vol. 112, no. 8, pp. 1402–1411, 2014.
@article{5798804,
  abstract     = {The present study evaluated the effect of different levels of energy restriction on metabolic parameters in obese ponies. Relative weight changes, markers of lipid metabolism, and oxidant/antioxidant balance were monitored. Eighteen obese (body condition score≥7/9) Shetland ponies were studied over a 23.5 week trial, divided into 3 periods. First a 4 week adaptation period in which each animal was fed 100% of their maintenance energy requirements needed to maintain stable obese body weight (MERob). Then a 16.5 weeks weight loss period in which ponies were assigned to receive either 100% (control group, CONTROL), 80% (slow weight loss group, SLOW) or 60% (rapid weight loss group, RAPID) of their MERob. During the 3 week end phase period all animals were again fed 100% of their MERob. Relative weight loss was higher in RAPID (P<0.001) compared to SLOW. No linear relationship was found as a doubling in caloric restriction was accompanied with a tripling in weight loss. Relative weight gain afterwards in the end phase period was higher in RAPID (P<0.001) compared to SLOW and CONTROL. During the weight loss period, triacylglycerol and non-esterified fatty acids levels were highest in RAPID, as were α-tocopherol and ferric reducing ability of plasma. After 8 weeks of weight loss, advanced oxidation protein products were higher in RAPID compared to SLOW and CONTROL (P<0.001). In conclusion, the level of energy restriction influences the extent of changes in oxidant/antioxidant balance. Practically, more severe energy restriction regimens may be associated with a greater regain of weight post restriction.},
  author       = {Bruynsteen, Lien and Janssens, Geert and Harris, Patricia A and Duchateau, Luc and Valle, Emanuela and Odetti, Patrizio and Vandevelde, Kimberley and Buyse, Johan and Hesta, Myriam},
  issn         = {0007-1145},
  journal      = {BRITISH JOURNAL OF NUTRITION},
  keywords     = {Energy restriction,Ponies,Weight-loss rate,Oxidative stress,WEIGHT-LOSS,ADVANCED GLYCATION,INSULIN SENSITIVITY,DIETARY RESTRICTION,LIPID-PEROXIDATION,METABOLIC SYNDROME,END-PRODUCTS,HORSES,PLASMA,ANTIOXIDANTS},
  language     = {eng},
  number       = {8},
  pages        = {1402--1411},
  title        = {Changes in oxidative stress in response to different levels of energy restriction in obese ponies},
  url          = {http://dx.doi.org/10.1017/S0007114514001974},
  volume       = {112},
  year         = {2014},
}

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