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Evaluation of a compact, high-resolution SPECT detector based on digital silicon photomultipliers

Carmen Bouckaert, Stefaan Vandenberghe UGent and Roel Van Holen UGent (2014) PHYSICS IN MEDICINE AND BIOLOGY. 59(23). p.7521-7539
abstract
MicroSPECT is one of the main functional imaging techniques used in the preclinical setting. Even though high-resolution images can be obtained with currently available systems, their sensitivity is often quite low due to the use of multi-pinhole collimation. This results in long acquisition times and hampers dynamic imaging. However, it has already been shown that this limited sensitivity can be overcome using high-resolution detectors. In this article, we therefore investigated the use of a digital photon counter (DPC) in combination with a 2 mm thick monolithic LYSO crystal for SPECT imaging. These light sensors contain arrays of avalanche photodiodes whose signals are directly digitised. The DPCs have the advantage that they are very compact, have a high intrinsic resolution, are MR compatible and allow disabling cells with a high dark count rate. In order to investigate the influence of the temperature dependent dark count rate on the detector performance, we compared it at 3 °C and 18 °C. At 3 °C, we observed an energy resolution of 28.8% and an intrinsic spatial resolution of 0.48 mm. Furthermore, the count rate at 10% loss is 60 kcps. Next, we looked at the event loss at 18 °C caused by the higher dark count rate and found a 5% loss compared to the 3 °C measurements. At this higher temperature the energy resolution becomes 29.2% and the intrinsic spatial resolution decreases to 0.52 mm. Due to the 5% count loss, the count rate at 10% loss increases to 63 kcps. A small degradation of the detector performance is thus observed at 18 °C. These results show the usefulness of this detector for SPECT imaging together with its excellent intrinsic spatial resolution. A drawback of the detector is its low, spatially varying energy resolution. Even though the detection efficiency and intrinsic spatial resolution are better at 3 °C, results are still acceptable at 18 °C.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
SIMULATION, CAMERA, MATRIX, SPECT, BRAIN SPECT, PINHOLE SPECT, SYSTEM, ARRAYS, PERFORMANCE EVALUATION, SMALL-ANIMAL SPECT, SPATIAL-RESOLUTION, digital silicon photomultiplier, LYSO
journal title
PHYSICS IN MEDICINE AND BIOLOGY
volume
59
issue
23
pages
7521 - 7539
Web of Science type
Article
Web of Science id
000345254000027
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
2.761 (2014)
JCR rank
34/125 (2014)
JCR quartile
2 (2014)
ISSN
0031-9155
DOI
10.1088/0031-9155/59/23/7521
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5797337
handle
http://hdl.handle.net/1854/LU-5797337
alternative location
http://iopscience.iop.org/0031-9155/59/23/7521/
date created
2015-01-07 09:27:26
date last changed
2016-12-19 15:41:55
@article{5797337,
  abstract     = {MicroSPECT is one of the main functional imaging techniques used in the preclinical setting. Even though high-resolution images can be obtained with currently available systems, their sensitivity is often quite low due to the use of multi-pinhole collimation. This results in long acquisition times and hampers dynamic imaging. However, it has already been shown that this limited sensitivity can be overcome using high-resolution detectors. In this article, we therefore investigated the use of a digital photon counter (DPC) in combination with a 2 mm thick monolithic LYSO crystal for SPECT imaging. These light sensors contain arrays of avalanche photodiodes whose signals are directly digitised. The DPCs have the advantage that they are very compact, have a high intrinsic resolution, are MR compatible and allow disabling cells with a high dark count rate. In order to investigate the influence of the temperature dependent dark count rate on the detector performance, we compared it at 3 {\textdegree}C and 18 {\textdegree}C.
At 3 {\textdegree}C, we observed an energy resolution of 28.8\% and an intrinsic spatial resolution of 0.48 mm. Furthermore, the count rate at 10\% loss is 60 kcps. Next, we looked at the event loss at 18 {\textdegree}C caused by the higher dark count rate and found a 5\% loss compared to the 3 {\textdegree}C measurements. At this higher temperature the energy resolution becomes 29.2\% and the intrinsic spatial resolution decreases to 0.52 mm. Due to the 5\% count loss, the count rate at 10\% loss increases to 63 kcps. A small degradation of the detector performance is thus observed at 18 {\textdegree}C.
These results show the usefulness of this detector for SPECT imaging together with its excellent intrinsic spatial resolution. A drawback of the detector is its low, spatially varying energy resolution. Even though the detection efficiency and intrinsic spatial resolution are better at 3 {\textdegree}C, results are still acceptable at 18 {\textdegree}C.},
  author       = {Bouckaert, Carmen and Vandenberghe, Stefaan and Van Holen, Roel},
  issn         = {0031-9155},
  journal      = {PHYSICS IN MEDICINE AND BIOLOGY},
  keyword      = {SIMULATION,CAMERA,MATRIX,SPECT,BRAIN SPECT,PINHOLE SPECT,SYSTEM,ARRAYS,PERFORMANCE EVALUATION,SMALL-ANIMAL SPECT,SPATIAL-RESOLUTION,digital silicon photomultiplier,LYSO},
  language     = {eng},
  number       = {23},
  pages        = {7521--7539},
  title        = {Evaluation of a compact, high-resolution SPECT detector based on digital silicon photomultipliers},
  url          = {http://dx.doi.org/10.1088/0031-9155/59/23/7521},
  volume       = {59},
  year         = {2014},
}

Chicago
Bouckaert, Carmen, Stefaan Vandenberghe, and Roel Van Holen. 2014. “Evaluation of a Compact, High-resolution SPECT Detector Based on Digital Silicon Photomultipliers.” Physics in Medicine and Biology 59 (23): 7521–7539.
APA
Bouckaert, C., Vandenberghe, S., & Van Holen, R. (2014). Evaluation of a compact, high-resolution SPECT detector based on digital silicon photomultipliers. PHYSICS IN MEDICINE AND BIOLOGY, 59(23), 7521–7539.
Vancouver
1.
Bouckaert C, Vandenberghe S, Van Holen R. Evaluation of a compact, high-resolution SPECT detector based on digital silicon photomultipliers. PHYSICS IN MEDICINE AND BIOLOGY. 2014;59(23):7521–39.
MLA
Bouckaert, Carmen, Stefaan Vandenberghe, and Roel Van Holen. “Evaluation of a Compact, High-resolution SPECT Detector Based on Digital Silicon Photomultipliers.” PHYSICS IN MEDICINE AND BIOLOGY 59.23 (2014): 7521–7539. Print.