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International development of an EORTC questionnaire for assessing health-related quality of life in chronic myeloid leukemia patients: the EORTC QLQ-CML24

(2014) QUALITY OF LIFE RESEARCH. 23(3). p.825-836
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Abstract
Background: Health-related quality of life (HRQOL) is a key aspect for chronic myeloid leukemia (CML) patients. The aim of this study was to develop a disease-specific HRQOL questionnaire for patients with CML to supplement the European Organization for Research and Treatment of Cancer (EORTC)-QLQ C30. The process followed a predefined and systematic stepwise iterative process as defined by the EORTC guidelines for questionnaire development. The process was divided into 3 phases: (1) generation of relevant HRQOL issues, (2) operationalization of the HRQOL issues into a set of items, and (3) pretesting the questionnaire for relevance and acceptability. Descriptive statistics and psychometric analyses were also performed. Overall, 655 CML patients were enrolled in 10 countries including the USA and countries in Europe and Asia. Interviews with health-care professionals experienced in CML (n = 59) were also conducted. Results from the interviews, clinical experiences, and statistical analyses were used to develop the EORTC QLQ-CML24. The final module consists of 24 items assessing the following aspects: symptom burden, impact on daily life and on worry/mood, body image problems, and satisfaction with care and with social life. Internal consistency, assessed with Cronbach's alpha coefficients, ranged from 0.73 to 0.83 for the proposed scales. The EORTC QLQ-CML24 is an internationally developed HRQOL questionnaire for CML patients, and its implementation in clinical research and practice can provide important information to facilitate clinical decision-making.
Keywords
DASATINIB, NILOTINIB, THERAPY, POPULATION, IMATINIB, Chronic myeloid leukemia, Quality of life, Questionnaire, DIAGNOSED CHRONIC-PHASE, TYROSINE-KINASE INHIBITORS, REPORTED OUTCOMES, FOLLOW-UP, INTERFERON-ALPHA

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MLA
Efficace, Fabio, Michele Baccarani, Massimo Breccia, et al. “International Development of an EORTC Questionnaire for Assessing Health-related Quality of Life in Chronic Myeloid Leukemia Patients: The EORTC QLQ-CML24.” QUALITY OF LIFE RESEARCH 23.3 (2014): 825–836. Print.
APA
Efficace, Fabio, Baccarani, M., Breccia, M., Saussele, S., Abel, G., Caocci, G., Guilhot, F., et al. (2014). International development of an EORTC questionnaire for assessing health-related quality of life in chronic myeloid leukemia patients: the EORTC QLQ-CML24. QUALITY OF LIFE RESEARCH, 23(3), 825–836.
Chicago author-date
Efficace, Fabio, Michele Baccarani, Massimo Breccia, Susanne Saussele, Gregory Abel, Giovanni Caocci, François Guilhot, et al. 2014. “International Development of an EORTC Questionnaire for Assessing Health-related Quality of Life in Chronic Myeloid Leukemia Patients: The EORTC QLQ-CML24.” Quality of Life Research 23 (3): 825–836.
Chicago author-date (all authors)
Efficace, Fabio, Michele Baccarani, Massimo Breccia, Susanne Saussele, Gregory Abel, Giovanni Caocci, François Guilhot, Kim Cocks, Adel Naeem, Mirjam Sprangers, Simone Oerlemans, Weichu Chie, Fausto Castagnetti, Felice Bombaci, Giora Sharf, Annarita Cardoni, Lucien Noens, Stephan Pallua, Marzia Salvucci, Ourania Nicolatou-Galitis, Gianantonio Rosti, and Franco Mandelli. 2014. “International Development of an EORTC Questionnaire for Assessing Health-related Quality of Life in Chronic Myeloid Leukemia Patients: The EORTC QLQ-CML24.” Quality of Life Research 23 (3): 825–836.
Vancouver
1.
Efficace F, Baccarani M, Breccia M, Saussele S, Abel G, Caocci G, et al. International development of an EORTC questionnaire for assessing health-related quality of life in chronic myeloid leukemia patients: the EORTC QLQ-CML24. QUALITY OF LIFE RESEARCH. 2014;23(3):825–36.
IEEE
[1]
F. Efficace et al., “International development of an EORTC questionnaire for assessing health-related quality of life in chronic myeloid leukemia patients: the EORTC QLQ-CML24,” QUALITY OF LIFE RESEARCH, vol. 23, no. 3, pp. 825–836, 2014.
@article{5792896,
  abstract     = {Background: Health-related quality of life (HRQOL) is a key aspect for chronic myeloid leukemia (CML) patients. The aim of this study was to develop a disease-specific HRQOL questionnaire for patients with CML to supplement the European Organization for Research and Treatment of Cancer (EORTC)-QLQ C30. 
The process followed a predefined and systematic stepwise iterative process as defined by the EORTC guidelines for questionnaire development. The process was divided into 3 phases: (1) generation of relevant HRQOL issues, (2) operationalization of the HRQOL issues into a set of items, and (3) pretesting the questionnaire for relevance and acceptability. Descriptive statistics and psychometric analyses were also performed. 
Overall, 655 CML patients were enrolled in 10 countries including the USA and countries in Europe and Asia. Interviews with health-care professionals experienced in CML (n = 59) were also conducted. Results from the interviews, clinical experiences, and statistical analyses were used to develop the EORTC QLQ-CML24. The final module consists of 24 items assessing the following aspects: symptom burden, impact on daily life and on worry/mood, body image problems, and satisfaction with care and with social life. Internal consistency, assessed with Cronbach's alpha coefficients, ranged from 0.73 to 0.83 for the proposed scales. 
The EORTC QLQ-CML24 is an internationally developed HRQOL questionnaire for CML patients, and its implementation in clinical research and practice can provide important information to facilitate clinical decision-making.},
  author       = {Efficace, Fabio and Baccarani, Michele and Breccia, Massimo and Saussele, Susanne and Abel, Gregory and Caocci, Giovanni and Guilhot, François and Cocks, Kim and Naeem, Adel and Sprangers, Mirjam and Oerlemans, Simone and Chie, Weichu and Castagnetti, Fausto and Bombaci, Felice and Sharf, Giora and Cardoni, Annarita and Noens, Lucien and Pallua, Stephan and Salvucci, Marzia and Nicolatou-Galitis, Ourania and Rosti, Gianantonio and Mandelli, Franco},
  issn         = {0962-9343},
  journal      = {QUALITY OF LIFE RESEARCH},
  keywords     = {DASATINIB,NILOTINIB,THERAPY,POPULATION,IMATINIB,Chronic myeloid leukemia,Quality of life,Questionnaire,DIAGNOSED CHRONIC-PHASE,TYROSINE-KINASE INHIBITORS,REPORTED OUTCOMES,FOLLOW-UP,INTERFERON-ALPHA},
  language     = {eng},
  number       = {3},
  pages        = {825--836},
  title        = {International development of an EORTC questionnaire for assessing health-related quality of life in chronic myeloid leukemia patients: the EORTC QLQ-CML24},
  url          = {http://dx.doi.org/10.1007/s11136-013-0523-5},
  volume       = {23},
  year         = {2014},
}

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