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Poly(2-oxazoline) hydrogels as next generation three-dimensional cell supports

(2014) CELL ADHESION & MIGRATION. 8(2). p.88-93
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Abstract
Synthetic hydrogels selectively decorated with cell adhesion motifs are rapidly emerging as promising substrates for 3D cell culture. When cells are grown in 3D they experience potentially more physiologically relevant cell-cell interactions and physical cues compared with traditional 2D cell culture on stiff surfaces. A newly developed polymer based on poly(2-oxazoline)s has been used for the first time to control attachment of fibroblast cells and is discussed here for its potential use in 3D cell culture with particular focus on cancer cells toward the ultimate aim of high-throughput screening of anticancer therapies. Advantages and limitations of using poly(2-oxazoline) hydrogels are discussed and compared with more established polymers, especially polyethylene glycol (PEG).
Keywords
hydrogel, cancer model, poly(2-oxazoline), synthetic polymer, 3D cell culture

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Citation

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MLA
Dargaville, Tim R., et al. “Poly(2-Oxazoline) Hydrogels as next Generation Three-Dimensional Cell Supports.” CELL ADHESION & MIGRATION, vol. 8, no. 2, 2014, pp. 88–93.
APA
Dargaville, T. R., Hollier, B. G., Shokoohmand, A., & Hoogenboom, R. (2014). Poly(2-oxazoline) hydrogels as next generation three-dimensional cell supports. CELL ADHESION & MIGRATION, 8(2), 88–93.
Chicago author-date
Dargaville, Tim R, Brett G Hollier, Ali Shokoohmand, and Richard Hoogenboom. 2014. “Poly(2-Oxazoline) Hydrogels as next Generation Three-Dimensional Cell Supports.” CELL ADHESION & MIGRATION 8 (2): 88–93.
Chicago author-date (all authors)
Dargaville, Tim R, Brett G Hollier, Ali Shokoohmand, and Richard Hoogenboom. 2014. “Poly(2-Oxazoline) Hydrogels as next Generation Three-Dimensional Cell Supports.” CELL ADHESION & MIGRATION 8 (2): 88–93.
Vancouver
1.
Dargaville TR, Hollier BG, Shokoohmand A, Hoogenboom R. Poly(2-oxazoline) hydrogels as next generation three-dimensional cell supports. CELL ADHESION & MIGRATION. 2014;8(2):88–93.
IEEE
[1]
T. R. Dargaville, B. G. Hollier, A. Shokoohmand, and R. Hoogenboom, “Poly(2-oxazoline) hydrogels as next generation three-dimensional cell supports,” CELL ADHESION & MIGRATION, vol. 8, no. 2, pp. 88–93, 2014.
@article{5791530,
  abstract     = {Synthetic hydrogels selectively decorated with cell adhesion motifs are rapidly emerging as promising substrates for 3D cell culture. When cells are grown in 3D they experience potentially more physiologically relevant cell-cell interactions and physical cues compared with traditional 2D cell culture on stiff surfaces. A newly developed polymer based on poly(2-oxazoline)s has been used for the first time to control attachment of fibroblast cells and is discussed here for its potential use in 3D cell culture with particular focus on cancer cells toward the ultimate aim of high-throughput screening of anticancer therapies. Advantages and limitations of using poly(2-oxazoline) hydrogels are discussed and compared with more established polymers, especially polyethylene glycol (PEG).},
  author       = {Dargaville, Tim R and Hollier, Brett G and Shokoohmand, Ali and Hoogenboom, Richard},
  issn         = {1933-6918},
  journal      = {CELL ADHESION & MIGRATION},
  keywords     = {hydrogel,cancer model,poly(2-oxazoline),synthetic polymer,3D cell culture},
  language     = {eng},
  number       = {2},
  pages        = {88--93},
  title        = {Poly(2-oxazoline) hydrogels as next generation three-dimensional cell supports},
  url          = {http://dx.doi.org/10.4161/cam.28205},
  volume       = {8},
  year         = {2014},
}

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