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An introduction to epigenetics as the link between genotype and environment: a personal view

Ann Van Soom UGent, Luc Peelman UGent, WV Holt and A Fazeli (2014) REPRODUCTION IN DOMESTIC ANIMALS. 49(suppl. 3). p.2-10
abstract
Lamarck was one of the first scientists who attempted to explain evolution, and he is especially well known for formulating the concept that acquired characteristics can be transmitted to future generations and may therefore steer evolution. Although Lamarckism fell out of favour soon after the publication of Darwin's work on natural selection and evolution, the concept of transmission of acquired characteristics has recently gained renewed attention and has led to some rethinking of the standard evolutionary model. Epigenetics, or the study of heritable (mitotically and/or meiotically) changes in gene activity that are not brought about by changes in the DNA sequence, can explain some types of ill health in offspring, which have been exposed to stressors during early development, when DNA is most susceptible to such epigenetic influences. In this review, we explain briefly the history of epigenetics and we propose some examples of epigenetic and transgenerational effects demonstrated in humans and animals. Growing evidence is available that the health and phenotype of a given individual is already shaped shortly before and after the time of conception. Some evidence suggests that epigenetic markings, which have been established around conception, can also be transmitted to future generations. This knowledge can possibly be used to revolutionize animal breeding and to increase human and animal health worldwide.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
ENDOCRINE DISRUPTORS, OFFSPRING SYNDROME, MONOZYGOTIC TWINS, SLOW GROWTH PERIOD, PRENATAL EXPOSURE, MOUSE DEVELOPMENT, DNA METHYLATION, DAIRY-COWS, CATTLE, INHERITANCE
journal title
REPRODUCTION IN DOMESTIC ANIMALS
Reprod. Domest. Anim.
volume
49
issue
suppl. 3
pages
2 - 10
Web of Science type
Review
Web of Science id
000342824200002
JCR category
VETERINARY SCIENCES
JCR impact factor
1.515 (2014)
JCR rank
30/133 (2014)
JCR quartile
1 (2014)
ISSN
0936-6768
DOI
10.1111/rda.12341
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5790264
handle
http://hdl.handle.net/1854/LU-5790264
date created
2014-12-23 16:09:59
date last changed
2016-12-19 15:43:14
@article{5790264,
  abstract     = {Lamarck was one of the first scientists who attempted to explain evolution, and he is especially well known for formulating the concept that acquired characteristics can be transmitted to future generations and may therefore steer evolution. Although Lamarckism fell out of favour soon after the publication of Darwin's work on natural selection and evolution, the concept of transmission of acquired characteristics has recently gained renewed attention and has led to some rethinking of the standard evolutionary model. Epigenetics, or the study of heritable (mitotically and/or meiotically) changes in gene activity that are not brought about by changes in the DNA sequence, can explain some types of ill health in offspring, which have been exposed to stressors during early development, when DNA is most susceptible to such epigenetic influences. In this review, we explain briefly the history of epigenetics and we propose some examples of epigenetic and transgenerational effects demonstrated in humans and animals. Growing evidence is available that the health and phenotype of a given individual is already shaped shortly before and after the time of conception. Some evidence suggests that epigenetic markings, which have been established around conception, can also be transmitted to future generations. This knowledge can possibly be used to revolutionize animal breeding and to increase human and animal health worldwide.},
  author       = {Van Soom, Ann and Peelman, Luc and Holt, WV and Fazeli, A},
  issn         = {0936-6768},
  journal      = {REPRODUCTION IN DOMESTIC ANIMALS},
  keyword      = {ENDOCRINE DISRUPTORS,OFFSPRING SYNDROME,MONOZYGOTIC TWINS,SLOW GROWTH PERIOD,PRENATAL EXPOSURE,MOUSE DEVELOPMENT,DNA METHYLATION,DAIRY-COWS,CATTLE,INHERITANCE},
  language     = {eng},
  number       = {suppl. 3},
  pages        = {2--10},
  title        = {An introduction to epigenetics as the link between genotype and environment: a personal view},
  url          = {http://dx.doi.org/10.1111/rda.12341},
  volume       = {49},
  year         = {2014},
}

Chicago
Van Soom, Ann, Luc Peelman, WV Holt, and A Fazeli. 2014. “An Introduction to Epigenetics as the Link Between Genotype and Environment: a Personal View.” Reproduction in Domestic Animals 49 (suppl. 3): 2–10.
APA
Van Soom, A., Peelman, L., Holt, W., & Fazeli, A. (2014). An introduction to epigenetics as the link between genotype and environment: a personal view. REPRODUCTION IN DOMESTIC ANIMALS, 49(suppl. 3), 2–10.
Vancouver
1.
Van Soom A, Peelman L, Holt W, Fazeli A. An introduction to epigenetics as the link between genotype and environment: a personal view. REPRODUCTION IN DOMESTIC ANIMALS. 2014;49(suppl. 3):2–10.
MLA
Van Soom, Ann, Luc Peelman, WV Holt, et al. “An Introduction to Epigenetics as the Link Between Genotype and Environment: a Personal View.” REPRODUCTION IN DOMESTIC ANIMALS 49.suppl. 3 (2014): 2–10. Print.