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Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia

(2014) SCIENCE SIGNALING. 7(352).
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Abstract
The posttranscriptional control of gene expression by microRNAs (miRNAs) is highly redundant, and compensatory effects limit the consequences of the inactivation of individual miRNAs. This implies that only a few miRNAs can function as effective tumor suppressors. It is also the basis of our strategy to define functionally relevant miRNA target genes that are not under redundant control by other miRNAs. We identified a functionally interconnected group of miRNAs that exhibited a reduced abundance in leukemia cells from patients with T cell acute lymphoblastic leukemia (T-ALL). To pinpoint relevant target genes, we applied a machine learning approach to eliminate genes that were subject to redundant miRNA-mediated control and to identify those genes that were exclusively targeted by tumor-suppressive miRNAs. This strategy revealed the convergence of a small group of tumor suppressor miRNAs on the Myb oncogene, as well as their effects on HBP1, which encodes a transcription factor. The expression of both genes was increased in T-ALL patient samples, and each gene promoted the progression of T-ALL in mice. Hence, our systematic analysis of tumor suppressor miRNA action identified a widespread mechanism of oncogene activation in T-ALL.
Keywords
CANCER-THERAPY, CHRONIC LYMPHOCYTIC-LEUKEMIA, TAL1 COMPLEX, MYB ONCOGENE, C-MYB, MICE, EXPRESSION, RNA, TRANSCRIPTION, INHIBITION

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Citation

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MLA
Sanghvi, Viraj R, Konstantinos J Mavrakis, Joni Van der Meulen, et al. “Characterization of a Set of Tumor Suppressor microRNAs in T Cell Acute Lymphoblastic Leukemia.” SCIENCE SIGNALING 7.352 (2014): n. pag. Print.
APA
Sanghvi, V. R., Mavrakis, K. J., Van der Meulen, J., Boice, M., Wolfe, A. L., Carty, M., Mohan, P., et al. (2014). Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia. SCIENCE SIGNALING, 7(352).
Chicago author-date
Sanghvi, Viraj R, Konstantinos J Mavrakis, Joni Van der Meulen, Michael Boice, Andrew L Wolfe, Mark Carty, Prathibha Mohan, et al. 2014. “Characterization of a Set of Tumor Suppressor microRNAs in T Cell Acute Lymphoblastic Leukemia.” Science Signaling 7 (352).
Chicago author-date (all authors)
Sanghvi, Viraj R, Konstantinos J Mavrakis, Joni Van der Meulen, Michael Boice, Andrew L Wolfe, Mark Carty, Prathibha Mohan, Pieter Rondou, Nicholas D Socci, Yves Benoit, Tom Taghon, Pieter Van Vlierberghe, Christina S Leslie, Franki Speleman, and Hans-Guido Wendel. 2014. “Characterization of a Set of Tumor Suppressor microRNAs in T Cell Acute Lymphoblastic Leukemia.” Science Signaling 7 (352).
Vancouver
1.
Sanghvi VR, Mavrakis KJ, Van der Meulen J, Boice M, Wolfe AL, Carty M, et al. Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia. SCIENCE SIGNALING. 2014;7(352).
IEEE
[1]
V. R. Sanghvi et al., “Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia,” SCIENCE SIGNALING, vol. 7, no. 352, 2014.
@article{5787378,
  abstract     = {The posttranscriptional control of gene expression by microRNAs (miRNAs) is highly redundant, and compensatory effects limit the consequences of the inactivation of individual miRNAs. This implies that only a few miRNAs can function as effective tumor suppressors. It is also the basis of our strategy to define functionally relevant miRNA target genes that are not under redundant control by other miRNAs. We identified a functionally interconnected group of miRNAs that exhibited a reduced abundance in leukemia cells from patients with T cell acute lymphoblastic leukemia (T-ALL). To pinpoint relevant target genes, we applied a machine learning approach to eliminate genes that were subject to redundant miRNA-mediated control and to identify those genes that were exclusively targeted by tumor-suppressive miRNAs. This strategy revealed the convergence of a small group of tumor suppressor miRNAs on the Myb oncogene, as well as their effects on HBP1, which encodes a transcription factor. The expression of both genes was increased in T-ALL patient samples, and each gene promoted the progression of T-ALL in mice. Hence, our systematic analysis of tumor suppressor miRNA action identified a widespread mechanism of oncogene activation in T-ALL.},
  articleno    = {ra111},
  author       = {Sanghvi, Viraj R and Mavrakis, Konstantinos J and Van der Meulen, Joni and Boice, Michael and Wolfe, Andrew L and Carty, Mark and Mohan, Prathibha and Rondou, Pieter and Socci, Nicholas D and Benoit, Yves and Taghon, Tom and Van Vlierberghe, Pieter and Leslie, Christina S and Speleman, Franki and Wendel, Hans-Guido},
  issn         = {1945-0877},
  journal      = {SCIENCE SIGNALING},
  keywords     = {CANCER-THERAPY,CHRONIC LYMPHOCYTIC-LEUKEMIA,TAL1 COMPLEX,MYB ONCOGENE,C-MYB,MICE,EXPRESSION,RNA,TRANSCRIPTION,INHIBITION},
  language     = {eng},
  number       = {352},
  pages        = {10},
  title        = {Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia},
  url          = {http://dx.doi.org/10.1126/scisignal.2005500},
  volume       = {7},
  year         = {2014},
}

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