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Genetic parameters for chronic progressive lymphedema in Belgian Draught Horses

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Abstract
Genetic parameters for chronic progressive lymphedema (CPL)-associated traits in Belgian Draught Horses were estimated, using a multitrait animal model. Clinical scores of CPL in the four limbs/horse (CPLclin), skinfold thickness and hair samples (hair diameter) were studied. Due to CPLclin uncertainty in younger horses (progressive CPL character), a restricted data set (D_3+) was formed, excluding records from horses under 3 years from the complete data set (D_full). Age, gender, coat colour and limb hair pigmentation were included as fixed, permanent environment and date of recording as random effects. Higher CPLclin certainty (D_3+) increased heritability coefficients of, and genetic correlations between traits, with CPLclin heritabilities (SE) for the respective data sets: 0.11 (0.06) and 0.26 (0.05). A large proportion of the CPLclin variance was attributed to the permanent environmental effect in D_full, but less in D_3+. Date of recording explained a proportion of variance from 0.09 +/- 0.03 to 0.61 +/- 0.08. Additive genetic correlations between CPLclin and both skinfold thickness and hair diameter showed the latter two traits cannot be used as a direct diagnostic aid for CPL. Due to the relatively low heritability of CPLclin, selection should focus on estimated breeding values (from repeated clinical examinations) to reduce CPL occurrence in the Belgian Draught Horse.
Keywords
hair diameter, CHRONIC PASTERN DERMATITIS, skinfold thickness, heritability, chronic progressive lymphedema, Draught horse, BREEDS, SWEDISH, LOCATION, CANDIDATE, PREVALENCE, POPULATION, HAIR THICKNESS, WARMBLOOD HORSES

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MLA
De Keyser, Kirsten, Steven Janssens, LM Peeters, et al. “Genetic Parameters for Chronic Progressive Lymphedema in Belgian Draught Horses.” JOURNAL OF ANIMAL BREEDING AND GENETICS 131.6 (2014): 522–528. Print.
APA
De Keyser, Kirsten, Janssens, S., Peeters, L., Foqué, N., Gasthuys, F., Oosterlinck, M., & Buys, N. (2014). Genetic parameters for chronic progressive lymphedema in Belgian Draught Horses. JOURNAL OF ANIMAL BREEDING AND GENETICS, 131(6), 522–528.
Chicago author-date
De Keyser, Kirsten, Steven Janssens, LM Peeters, N Foqué, Frank Gasthuys, Maarten Oosterlinck, and Nadine Buys. 2014. “Genetic Parameters for Chronic Progressive Lymphedema in Belgian Draught Horses.” Journal of Animal Breeding and Genetics 131 (6): 522–528.
Chicago author-date (all authors)
De Keyser, Kirsten, Steven Janssens, LM Peeters, N Foqué, Frank Gasthuys, Maarten Oosterlinck, and Nadine Buys. 2014. “Genetic Parameters for Chronic Progressive Lymphedema in Belgian Draught Horses.” Journal of Animal Breeding and Genetics 131 (6): 522–528.
Vancouver
1.
De Keyser K, Janssens S, Peeters L, Foqué N, Gasthuys F, Oosterlinck M, et al. Genetic parameters for chronic progressive lymphedema in Belgian Draught Horses. JOURNAL OF ANIMAL BREEDING AND GENETICS. 2014;131(6):522–8.
IEEE
[1]
K. De Keyser et al., “Genetic parameters for chronic progressive lymphedema in Belgian Draught Horses,” JOURNAL OF ANIMAL BREEDING AND GENETICS, vol. 131, no. 6, pp. 522–528, 2014.
@article{5786297,
  abstract     = {{Genetic parameters for chronic progressive lymphedema (CPL)-associated traits in Belgian Draught Horses were estimated, using a multitrait animal model. Clinical scores of CPL in the four limbs/horse (CPLclin), skinfold thickness and hair samples (hair diameter) were studied. Due to CPLclin uncertainty in younger horses (progressive CPL character), a restricted data set (D_3+) was formed, excluding records from horses under 3 years from the complete data set (D_full). Age, gender, coat colour and limb hair pigmentation were included as fixed, permanent environment and date of recording as random effects. Higher CPLclin certainty (D_3+) increased heritability coefficients of, and genetic correlations between traits, with CPLclin heritabilities (SE) for the respective data sets: 0.11 (0.06) and 0.26 (0.05). A large proportion of the CPLclin variance was attributed to the permanent environmental effect in D_full, but less in D_3+. Date of recording explained a proportion of variance from 0.09 +/- 0.03 to 0.61 +/- 0.08. Additive genetic correlations between CPLclin and both skinfold thickness and hair diameter showed the latter two traits cannot be used as a direct diagnostic aid for CPL. Due to the relatively low heritability of CPLclin, selection should focus on estimated breeding values (from repeated clinical examinations) to reduce CPL occurrence in the Belgian Draught Horse.}},
  author       = {{De Keyser, Kirsten and Janssens, Steven and Peeters, LM and Foqué, N and Gasthuys, Frank and Oosterlinck, Maarten and Buys, Nadine}},
  issn         = {{0931-2668}},
  journal      = {{JOURNAL OF ANIMAL BREEDING AND GENETICS}},
  keywords     = {{hair diameter,CHRONIC PASTERN DERMATITIS,skinfold thickness,heritability,chronic progressive lymphedema,Draught horse,BREEDS,SWEDISH,LOCATION,CANDIDATE,PREVALENCE,POPULATION,HAIR THICKNESS,WARMBLOOD HORSES}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{522--528}},
  title        = {{Genetic parameters for chronic progressive lymphedema in Belgian Draught Horses}},
  url          = {{http://dx.doi.org/10.1111/jbg.12087}},
  volume       = {{131}},
  year         = {{2014}},
}

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