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The Cu(OTf)2 catalysed microwave assisted synthesis of a new scaffold, 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-one

Koen Muylaert (UGent) , Sven Mangelinckx (UGent) , Martyna Jatczak (UGent) , Laurens De Coen (UGent) , Kristof Van Hecke (UGent) and Christian Stevens (UGent)
(2014) ARKIVOC. p.139-155
Author
Organization
Abstract
The synthesis of novel 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-ones is described including a one-step Mannich-type reaction followed by intramolecular ring closure of ethyl 3-methylpyridazine-4- carboxylate and aldimines, catalysed by the Lewis acid Cu(OTf)2 under microwave heating. This synthesis opens up possibilities to access this unexplored scaffold for medicinal chemistry.
Keywords
microwave irradiation, nitrogen heterocycles, Pyridopyridazinones, COMBINATORIAL LIBRARIES, 2, 4-METHANOPROLINE, ANALOGS

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MLA
Muylaert, Koen, Sven Mangelinckx, Martyna Jatczak, et al. “The Cu(OTf)2 Catalysed Microwave Assisted Synthesis of a New Scaffold, 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-one.” ARKIVOC 6 (2014): 139–155. Print.
APA
Muylaert, Koen, Mangelinckx, S., Jatczak, M., De Coen, L., Van Hecke, K., & Stevens, C. (2014). The Cu(OTf)2 catalysed microwave assisted synthesis of a new scaffold, 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-one. ARKIVOC, (6), 139–155.
Chicago author-date
Muylaert, Koen, Sven Mangelinckx, Martyna Jatczak, Laurens De Coen, Kristof Van Hecke, and Christian Stevens. 2014. “The Cu(OTf)2 Catalysed Microwave Assisted Synthesis of a New Scaffold, 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-one.” Arkivoc (6): 139–155.
Chicago author-date (all authors)
Muylaert, Koen, Sven Mangelinckx, Martyna Jatczak, Laurens De Coen, Kristof Van Hecke, and Christian Stevens. 2014. “The Cu(OTf)2 Catalysed Microwave Assisted Synthesis of a New Scaffold, 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-one.” Arkivoc (6): 139–155.
Vancouver
1.
Muylaert K, Mangelinckx S, Jatczak M, De Coen L, Van Hecke K, Stevens C. The Cu(OTf)2 catalysed microwave assisted synthesis of a new scaffold, 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-one. ARKIVOC. 2014;(6):139–55.
IEEE
[1]
K. Muylaert, S. Mangelinckx, M. Jatczak, L. De Coen, K. Van Hecke, and C. Stevens, “The Cu(OTf)2 catalysed microwave assisted synthesis of a new scaffold, 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-one,” ARKIVOC, no. 6, pp. 139–155, 2014.
@article{5782083,
  abstract     = {The synthesis of novel 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-ones is described including a one-step Mannich-type reaction followed by intramolecular ring closure of ethyl 3-methylpyridazine-4- carboxylate and aldimines, catalysed by the Lewis acid Cu(OTf)2 under microwave heating. This synthesis opens up possibilities to access this unexplored scaffold for medicinal chemistry.},
  author       = {Muylaert, Koen and Mangelinckx, Sven and Jatczak, Martyna and De Coen, Laurens and Van Hecke, Kristof and Stevens, Christian},
  issn         = {1551-7004},
  journal      = {ARKIVOC},
  keywords     = {microwave irradiation,nitrogen heterocycles,Pyridopyridazinones,COMBINATORIAL LIBRARIES,2,4-METHANOPROLINE,ANALOGS},
  language     = {eng},
  number       = {6},
  pages        = {139--155},
  title        = {The Cu(OTf)2 catalysed microwave assisted synthesis of a new scaffold, 7-aryl-7,8-dihydropyrido[4,3-c]pyridazin-5(6H)-one},
  url          = {http://dx.doi.org/10.3998/ark.5550190.p008.934},
  year         = {2014},
}

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