Ghent University Academic Bibliography

Advanced

Association between Mycoplasma genitalium infection and HIV acquisition among female sex workers in Uganda : evidence from a nested case-control study

Judith Vandepitte, Helen A Weiss, Justine Bukenya, Nassim Kyakuwa, Etienne Muller, Anne Buvé, Patrick Van Der Stuyft UGent, Richard J Hayes and Heiner Grosskurth (2014) SEXUALLY TRANSMITTED INFECTIONS. 90(7). p.545-549
abstract
Objectives: Cross-sectional studies have shown a strong association between Mycoplasma genitalium and HIV infections. We previously reported that in a cohort of female sex workers in Uganda, M genitalium infection at baseline was associated with HIV seroconversion. Here we examine the temporal association between the M genitalium infection status shortly before HIV seroconversion and HIV acquisition. Methods: A nested case-control study was conducted within a cohort of women at high risk for HIV in Kampala. Cases were those of women acquiring HIV within 2 years of enrolment. For each of the 42 cases, 3 controls were selected from women HIV negative at the visit when the corresponding case first tested HIV seropositive. The association between HIV acquisition and M genitalium infection immediately prior to HIV testing was analysed using conditional logistic regression. Results: There was weak evidence of an association between M genitalium infection and HIV acquisition overall (crude OR= 1.57; 95% CI 0.67 to 3.72, aOR= 2.28: 95% CI 0.81 to 6.47). However, time of M genitalium testing affected the association (p value for effect-modification= 0.004). For 29 case-control sets with endocervical samples tested 3 months prior to the first HIV-positive result, M genitalium infection increased the risk of HIV acquisition (crude OR= 3.09; 95% CI 1.06 to 9.05, aOR= 7.19; 95% CI 1.68 to 30.77), whereas there was little evidence of an association among the 13 case-control sets with samples tested at an earlier visit (crude OR= 0.30: 95% CI 0.04 to 2.51; aOR= 0.34; 95% CI 0.02 to 5.94). Conclusions: Our study showed evidence of a temporal relationship between M genitalium infection and HIV acquisition that suggests that M genitalium infection may be a co-factor in the acquisition of HIV infection.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
WOMEN, PREVALENCE, KAMPALA, EPITHELIAL-CELLS, CYTOKINE SECRETION, COHORT, RISK
journal title
SEXUALLY TRANSMITTED INFECTIONS
Sex. Transm. Infect.
volume
90
issue
7
pages
545 - 549
Web of Science type
Article
Web of Science id
000344104100012
JCR category
INFECTIOUS DISEASES
JCR impact factor
3.401 (2014)
JCR rank
25/78 (2014)
JCR quartile
2 (2014)
ISSN
1368-4973
DOI
10.1136/sextrans-2013-051467
language
English
UGent publication?
yes
classification
A1
copyright statement
I have retained and own the full copyright for this publication
id
5779863
handle
http://hdl.handle.net/1854/LU-5779863
date created
2014-12-10 14:03:13
date last changed
2017-10-12 14:50:42
@article{5779863,
  abstract     = {Objectives: Cross-sectional studies have shown a strong association between Mycoplasma genitalium and HIV infections. We previously reported that in a cohort of female sex workers in Uganda, M genitalium infection at baseline was associated with HIV seroconversion. Here we examine the temporal association between the M genitalium infection status shortly before HIV seroconversion and HIV acquisition. 
Methods: A nested case-control study was conducted within a cohort of women at high risk for HIV in Kampala. Cases were those of women acquiring HIV within 2 years of enrolment. For each of the 42 cases, 3 controls were selected from women HIV negative at the visit when the corresponding case first tested HIV seropositive. The association between HIV acquisition and M genitalium infection immediately prior to HIV testing was analysed using conditional logistic regression. 
Results: There was weak evidence of an association between M genitalium infection and HIV acquisition overall (crude OR= 1.57; 95\% CI 0.67 to 3.72, aOR= 2.28: 95\% CI 0.81 to 6.47). However, time of M genitalium testing affected the association (p value for effect-modification= 0.004). For 29 case-control sets with endocervical samples tested 3 months prior to the first HIV-positive result, M genitalium infection increased the risk of HIV acquisition (crude OR= 3.09; 95\% CI 1.06 to 9.05, aOR= 7.19; 95\% CI 1.68 to 30.77), whereas there was little evidence of an association among the 13 case-control sets with samples tested at an earlier visit (crude OR= 0.30: 95\% CI 0.04 to 2.51; aOR= 0.34; 95\% CI 0.02 to 5.94). 
Conclusions: Our study showed evidence of a temporal relationship between M genitalium infection and HIV acquisition that suggests that M genitalium infection may be a co-factor in the acquisition of HIV infection.},
  author       = {Vandepitte, Judith and Weiss, Helen A and Bukenya, Justine and Kyakuwa, Nassim and Muller, Etienne and Buv{\'e}, Anne and Van Der Stuyft, Patrick and Hayes, Richard J and Grosskurth, Heiner},
  issn         = {1368-4973},
  journal      = {SEXUALLY TRANSMITTED INFECTIONS},
  keyword      = {WOMEN,PREVALENCE,KAMPALA,EPITHELIAL-CELLS,CYTOKINE SECRETION,COHORT,RISK},
  language     = {eng},
  number       = {7},
  pages        = {545--549},
  title        = {Association between Mycoplasma genitalium infection and HIV acquisition among female sex workers in Uganda : evidence from a nested case-control study},
  url          = {http://dx.doi.org/10.1136/sextrans-2013-051467},
  volume       = {90},
  year         = {2014},
}

Chicago
Vandepitte, Judith, Helen A Weiss, Justine Bukenya, Nassim Kyakuwa, Etienne Muller, Anne Buvé, Patrick Van Der Stuyft, Richard J Hayes, and Heiner Grosskurth. 2014. “Association Between Mycoplasma Genitalium Infection and HIV Acquisition Among Female Sex Workers in Uganda : Evidence from a Nested Case-control Study.” Sexually Transmitted Infections 90 (7): 545–549.
APA
Vandepitte, J., Weiss, H. A., Bukenya, J., Kyakuwa, N., Muller, E., Buvé, A., Van Der Stuyft, P., et al. (2014). Association between Mycoplasma genitalium infection and HIV acquisition among female sex workers in Uganda : evidence from a nested case-control study. SEXUALLY TRANSMITTED INFECTIONS, 90(7), 545–549.
Vancouver
1.
Vandepitte J, Weiss HA, Bukenya J, Kyakuwa N, Muller E, Buvé A, et al. Association between Mycoplasma genitalium infection and HIV acquisition among female sex workers in Uganda : evidence from a nested case-control study. SEXUALLY TRANSMITTED INFECTIONS. 2014;90(7):545–9.
MLA
Vandepitte, Judith, Helen A Weiss, Justine Bukenya, et al. “Association Between Mycoplasma Genitalium Infection and HIV Acquisition Among Female Sex Workers in Uganda : Evidence from a Nested Case-control Study.” SEXUALLY TRANSMITTED INFECTIONS 90.7 (2014): 545–549. Print.