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The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs

(2014) PLOS ONE. 9(10).
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Abstract
To gain insights into the working mechanism of morphine, regional cerebral blood flow (rCBF) patterns after morphine administration were assessed in dogs. In a randomized cross-over experimental study, rCBF was estimated with Tc-99m-Ethylcysteinate Dimer single photon emission computed tomography in 8 dogs at baseline, at 30 minutes and at 120 minutes after a single bolus of morphine. Perfusion indices (PI) in the frontal, parietal, temporal and occipital cortex and in the subcortical and cerebellar region were calculated. PI was significantly decreased 30 min after morphine compared to baseline in the right frontal cortex. The left parietal cortex and subcortical region showed a significantly increased PI 30 min after morphine compared to baseline. No significant differences were noted for the other regions or at other time points. In conclusion, a single bolus of morphine generated a changing rCBF pattern at different time points.
Keywords
METABOLISM, PHARMACOLOGY, REMIFENTANIL, FENTANYL, RAT, CONSCIOUS DOGS, NALOXONE, MU-OPIOID RECEPTOR, POSITRON-EMISSION-TOMOGRAPHY, CYSTEINATE DIMER SPECT

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Citation

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Chicago
Adriaens, Antita, Kathelijne Peremans, Tim Waelbers, Eva Vandermeulen, Siska Croubels, Luc Duchateau, André Dobbeleir, et al. 2014. “The Effect of Morphine on Regional Cerebral Blood Flow Measured by 99mTc-ECD SPECT in Dogs.” Plos One 9 (10).
APA
Adriaens, Antita, Peremans, K., Waelbers, T., Vandermeulen, E., Croubels, S., Duchateau, L., Dobbeleir, A., et al. (2014). The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs. PLOS ONE, 9(10).
Vancouver
1.
Adriaens A, Peremans K, Waelbers T, Vandermeulen E, Croubels S, Duchateau L, et al. The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs. PLOS ONE. 2014;9(10).
MLA
Adriaens, Antita, Kathelijne Peremans, Tim Waelbers, et al. “The Effect of Morphine on Regional Cerebral Blood Flow Measured by 99mTc-ECD SPECT in Dogs.” PLOS ONE 9.10 (2014): n. pag. Print.
@article{5778827,
  abstract     = {To gain insights into the working mechanism of morphine, regional cerebral blood flow (rCBF) patterns after morphine administration were assessed in dogs. In a randomized cross-over experimental study, rCBF was estimated with Tc-99m-Ethylcysteinate Dimer single photon emission computed tomography in 8 dogs at baseline, at 30 minutes and at 120 minutes after a single bolus of morphine. Perfusion indices (PI) in the frontal, parietal, temporal and occipital cortex and in the subcortical and cerebellar region were calculated. PI was significantly decreased 30 min after morphine compared to baseline in the right frontal cortex. The left parietal cortex and subcortical region showed a significantly increased PI 30 min after morphine compared to baseline. No significant differences were noted for the other regions or at other time points. In conclusion, a single bolus of morphine generated a changing rCBF pattern at different time points.},
  articleno    = {e109680},
  author       = {Adriaens, Antita and Peremans, Kathelijne and Waelbers, Tim and Vandermeulen, Eva and Croubels, Siska and Duchateau, Luc and Dobbeleir, Andr{\'e} and Audenaert, Kurt and Eersels, Jos and Vermeire, Simon and De Spiegeleer, Bart and Polis, Ingeborgh},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  language     = {eng},
  number       = {10},
  pages        = {5},
  title        = {The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs},
  url          = {http://dx.doi.org/10.1371/journal.pone.0109680},
  volume       = {9},
  year         = {2014},
}

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