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Short- and long-term clinical skin effects of testosterone treatment in trans men

(2014) JOURNAL OF SEXUAL MEDICINE. 11(1). p.222-229
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Abstract
Introduction : Our knowledge concerning the effects of testosterone (T) therapy on the skin of trans men (female-to-male transsexuals) is scarce. Aim : The aim of this study was to evaluate the short- and long-term clinical effects of T treatment on the skin of trans men. Methods : We conducted a prospective intervention study in 20 hormone naive trans men and a cross-sectional study in 50 trans men with an average of 10 years on T therapy. Main Outcome Measures : Acne lesions were assessed using the Gradual Acne Grading Scale, hair patterns using the Ferriman and Gallwey classification (F&G), and androgenetic alopecia using the Norwood Hamilton Scale. Results : T treatment increased facial and body hair growth. The F&G score increased progressively from a median value of 0.5 at baseline to a value of 12 after 12 months of T administration. After long-term T treatment, all but one trans man achieved an F&G score indicative of hirsutism in women, with a median value of 24. Only one trans man acquired mild frontotemporal hair loss during the first year of T treatment, whereas 32.7% of trans men had mild frontotemporal hair loss and 31% had moderate to severe androgenetic alopecia after long-term T therapy. The presence and severity of acne increased during the first year of T therapy, and peaked at 6 months. After long-term T treatment, most participants had no or mild acne lesions (93.9%). Dermatological outcome was not demonstrably related to individual serum T or dihydrotestosterone levels. Conclusions : T treatment increased facial and body hair in a time-dependent manner. The prevalence and severity of acne in the majority of trans men peaked 6 months after beginning T therapy. Severe skin problems were absent after short- and long-term T treatment.
Keywords
FOLLICLES, ACNE, RECEPTOR, PRACTICE GUIDELINE, SEBUM PRODUCTION, HIRSUTISM, WOMEN, HAIR-GROWTH, ANDROGENETIC ALOPECIA, TRANSSEXUAL PERSONS, Gender Dysphoria, Female-to-Male Transsexual, Skin, Transsexualism, Testosterone, Gender Identity Disorder

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Citation

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MLA
Wierckx, Katrien, Fleur Van de Peer, Evelien Verhaeghe, et al. “Short- and Long-term Clinical Skin Effects of Testosterone Treatment in Trans Men.” JOURNAL OF SEXUAL MEDICINE 11.1 (2014): 222–229. Print.
APA
Wierckx, K., Van de Peer, F., Verhaeghe, E., Dedecker, D., Van Caenegem, E., Toye, K., Kaufman, J., et al. (2014). Short- and long-term clinical skin effects of testosterone treatment in trans men. JOURNAL OF SEXUAL MEDICINE, 11(1), 222–229.
Chicago author-date
Wierckx, Katrien, Fleur Van de Peer, Evelien Verhaeghe, David Dedecker, Eva Van Caenegem, Kaatje Toye, Jean Kaufman, and Guy T’Sjoen. 2014. “Short- and Long-term Clinical Skin Effects of Testosterone Treatment in Trans Men.” Journal of Sexual Medicine 11 (1): 222–229.
Chicago author-date (all authors)
Wierckx, Katrien, Fleur Van de Peer, Evelien Verhaeghe, David Dedecker, Eva Van Caenegem, Kaatje Toye, Jean Kaufman, and Guy T’Sjoen. 2014. “Short- and Long-term Clinical Skin Effects of Testosterone Treatment in Trans Men.” Journal of Sexual Medicine 11 (1): 222–229.
Vancouver
1.
Wierckx K, Van de Peer F, Verhaeghe E, Dedecker D, Van Caenegem E, Toye K, et al. Short- and long-term clinical skin effects of testosterone treatment in trans men. JOURNAL OF SEXUAL MEDICINE. 2014;11(1):222–9.
IEEE
[1]
K. Wierckx et al., “Short- and long-term clinical skin effects of testosterone treatment in trans men,” JOURNAL OF SEXUAL MEDICINE, vol. 11, no. 1, pp. 222–229, 2014.
@article{5776225,
  abstract     = {Introduction : Our knowledge concerning the effects of testosterone (T) therapy on the skin of trans men (female-to-male transsexuals) is scarce. 
Aim : The aim of this study was to evaluate the short- and long-term clinical effects of T treatment on the skin of trans men. 
Methods : We conducted a prospective intervention study in 20 hormone naive trans men and a cross-sectional study in 50 trans men with an average of 10 years on T therapy. 
Main Outcome Measures : Acne lesions were assessed using the Gradual Acne Grading Scale, hair patterns using the Ferriman and Gallwey classification (F&G), and androgenetic alopecia using the Norwood Hamilton Scale. 
Results : T treatment increased facial and body hair growth. The F&G score increased progressively from a median value of 0.5 at baseline to a value of 12 after 12 months of T administration. After long-term T treatment, all but one trans man achieved an F&G score indicative of hirsutism in women, with a median value of 24. Only one trans man acquired mild frontotemporal hair loss during the first year of T treatment, whereas 32.7% of trans men had mild frontotemporal hair loss and 31% had moderate to severe androgenetic alopecia after long-term T therapy. The presence and severity of acne increased during the first year of T therapy, and peaked at 6 months. After long-term T treatment, most participants had no or mild acne lesions (93.9%). Dermatological outcome was not demonstrably related to individual serum T or dihydrotestosterone levels. 
Conclusions : T treatment increased facial and body hair in a time-dependent manner. The prevalence and severity of acne in the majority of trans men peaked 6 months after beginning T therapy. Severe skin problems were absent after short- and long-term T treatment.},
  author       = {Wierckx, Katrien and Van de Peer, Fleur and Verhaeghe, Evelien and Dedecker, David and Van Caenegem, Eva and Toye, Kaatje and Kaufman, Jean and T'Sjoen, Guy},
  issn         = {1743-6095},
  journal      = {JOURNAL OF SEXUAL MEDICINE},
  keywords     = {FOLLICLES,ACNE,RECEPTOR,PRACTICE GUIDELINE,SEBUM PRODUCTION,HIRSUTISM,WOMEN,HAIR-GROWTH,ANDROGENETIC ALOPECIA,TRANSSEXUAL PERSONS,Gender Dysphoria,Female-to-Male Transsexual,Skin,Transsexualism,Testosterone,Gender Identity Disorder},
  language     = {eng},
  number       = {1},
  pages        = {222--229},
  title        = {Short- and long-term clinical skin effects of testosterone treatment in trans men},
  url          = {http://dx.doi.org/10.1111/jsm.12366},
  volume       = {11},
  year         = {2014},
}

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