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Bone mineral density and chronic lung disease mortality: the Rotterdam study

Natalia Campos-Obando, Martha C Castano-Betancourt, Ling Oei, Oscar H Franco, Bruno HCh Stricker, Guy Brusselle UGent, Lies Lahousse UGent, Albert Hofman, Henning Tiemeier, Fernando Rivadeneira, et al. (2014) JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 99(5). p.1834-1842
abstract
Context: Low bone mineral density (BMD) has been associated with increased all-cause mortality. Cause-specific mortality studies have been controversial. Objective: The aim of the study was to investigate associations between BMD and all-cause mortality and in-depth cause-specific mortality. Design and Setting: We studied two cohorts from the prospective Rotterdam Study (RS), initiated in 1990 (RS-I) and 2000 (RS-II) with average follow-up of 17.1 (RS-I) and 10.2 (RS-II) years until January 2011. Baseline femoral neck BMD was analyzed in SD values. Deaths were classified according to International Classification of Diseases into seven groups: cardiovascular diseases, cancer, infections, external, dementia, chronic lung diseases, and other causes. Gender-stratified Cox and competing-risks models were adjusted for age, body mass index, and smoking. Participants: The study included 5779 subjects from RS-I and 2055 from RS-II. Main Outcome Measurements: We measured all-cause and cause-specific mortality. Results: A significant inverse association between BMD and all-cause mortality was found in males [expressed as hazard ratio (95% confidence interval)]: RS-I, 1.07 (1.01-1.13), P = .020; RS-II, 1.31 (1.12-1.55), P = .001); but it was not found in females: RS-I, 1.05 (0.99-1.11), P = .098; RS-II, 0.91 (0.74-1.12), P = .362. An inverse association with chronic lung disease mortality was found in males [RS-I, 1.75 (1.34-2.29), P < .001; RS-II, 2.15 (1.05-4.42), P = .037] and in RS-I in females [1.72 (1.16-2.57); P = .008], persisting after multiple adjustments and excluding prevalent chronic obstructive pulmonary disease. A positive association between BMD and cancer mortality was detected in females in RS-I [0.89 (0.80-0.99); P = .043]. No association was found with cardiovascular mortality. Conclusions: BMD is inversely associated with mortality. The strong association of BMD with chronic lung disease mortality is a novel finding that needs further analysis to clarify underlying mechanisms.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
METAANALYSIS, ASSOCIATION, RISK, MEN, COPD, FOLLOW-UP, VERTEBRAL FRACTURES, OSTEOPOROTIC FRACTURES, OBSTRUCTIVE PULMONARY-DISEASE, OLDER WOMEN
journal title
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
J. Clin. Endocrinol. Metab.
volume
99
issue
5
pages
1834 - 1842
Web of Science type
Article
Web of Science id
000342339800068
JCR category
ENDOCRINOLOGY & METABOLISM
JCR impact factor
6.209 (2014)
JCR rank
15/128 (2014)
JCR quartile
1 (2014)
ISSN
0021-972X
DOI
10.1210/jc.2013-3819
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5771973
handle
http://hdl.handle.net/1854/LU-5771973
date created
2014-12-04 14:50:57
date last changed
2017-04-07 11:31:50
@article{5771973,
  abstract     = {Context: Low bone mineral density (BMD) has been associated with increased all-cause mortality. Cause-specific mortality studies have been controversial. 
Objective: The aim of the study was to investigate associations between BMD and all-cause mortality and in-depth cause-specific mortality. 
Design and Setting: We studied two cohorts from the prospective Rotterdam Study (RS), initiated in 1990 (RS-I) and 2000 (RS-II) with average follow-up of 17.1 (RS-I) and 10.2 (RS-II) years until January 2011. Baseline femoral neck BMD was analyzed in SD values. Deaths were classified according to International Classification of Diseases into seven groups: cardiovascular diseases, cancer, infections, external, dementia, chronic lung diseases, and other causes. Gender-stratified Cox and competing-risks models were adjusted for age, body mass index, and smoking. 
Participants: The study included 5779 subjects from RS-I and 2055 from RS-II. 
Main Outcome Measurements: We measured all-cause and cause-specific mortality. 
Results: A significant inverse association between BMD and all-cause mortality was found in males [expressed as hazard ratio (95\% confidence interval)]: RS-I, 1.07 (1.01-1.13), P = .020; RS-II, 1.31 (1.12-1.55), P = .001); but it was not found in females: RS-I, 1.05 (0.99-1.11), P = .098; RS-II, 0.91 (0.74-1.12), P = .362. An inverse association with chronic lung disease mortality was found in males [RS-I, 1.75 (1.34-2.29), P {\textlangle} .001; RS-II, 2.15 (1.05-4.42), P = .037] and in RS-I in females [1.72 (1.16-2.57); P = .008], persisting after multiple adjustments and excluding prevalent chronic obstructive pulmonary disease. A positive association between BMD and cancer mortality was detected in females in RS-I [0.89 (0.80-0.99); P = .043]. No association was found with cardiovascular mortality. 
Conclusions: BMD is inversely associated with mortality. The strong association of BMD with chronic lung disease mortality is a novel finding that needs further analysis to clarify underlying mechanisms.},
  author       = {Campos-Obando, Natalia and Castano-Betancourt, Martha C and Oei, Ling and Franco, Oscar H and Stricker, Bruno HCh and Brusselle, Guy and Lahousse, Lies and Hofman, Albert and Tiemeier, Henning and Rivadeneira, Fernando and Uitterlinden, Andr{\'e} G and Zillikens, M Carola},
  issn         = {0021-972X},
  journal      = {JOURNAL OF CLINICAL ENDOCRINOLOGY \& METABOLISM},
  keyword      = {METAANALYSIS,ASSOCIATION,RISK,MEN,COPD,FOLLOW-UP,VERTEBRAL FRACTURES,OSTEOPOROTIC FRACTURES,OBSTRUCTIVE PULMONARY-DISEASE,OLDER WOMEN},
  language     = {eng},
  number       = {5},
  pages        = {1834--1842},
  title        = {Bone mineral density and chronic lung disease mortality: the Rotterdam study},
  url          = {http://dx.doi.org/10.1210/jc.2013-3819},
  volume       = {99},
  year         = {2014},
}

Chicago
Campos-Obando, Natalia, Martha C Castano-Betancourt, Ling Oei, Oscar H Franco, Bruno Hch Stricker, Guy Brusselle, Lies Lahousse, et al. 2014. “Bone Mineral Density and Chronic Lung Disease Mortality: The Rotterdam Study.” Journal of Clinical Endocrinology & Metabolism 99 (5): 1834–1842.
APA
Campos-Obando, N., Castano-Betancourt, M. C., Oei, L., Franco, O. H., Stricker, B. Hc., Brusselle, G., Lahousse, L., et al. (2014). Bone mineral density and chronic lung disease mortality: the Rotterdam study. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 99(5), 1834–1842.
Vancouver
1.
Campos-Obando N, Castano-Betancourt MC, Oei L, Franco OH, Stricker BHc, Brusselle G, et al. Bone mineral density and chronic lung disease mortality: the Rotterdam study. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2014;99(5):1834–42.
MLA
Campos-Obando, Natalia, Martha C Castano-Betancourt, Ling Oei, et al. “Bone Mineral Density and Chronic Lung Disease Mortality: The Rotterdam Study.” JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 99.5 (2014): 1834–1842. Print.