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Genome-wide association analysis identifies six new loci associated with forced vital capacity

Daan W Loth, Maria Soler Artigas, Sina A Gharib, Louise V Wain, Nora Franceschini, Beate Koch, Tess D Pottinger, Albert Vernon Smith, Qing Duan, Chris Oldmeadow, et al. (2014) NATURE GENETICS. 46(7). p.669-677
abstract
Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P < 5 x 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
FAMILY, IDIOPATHIC PULMONARY-FIBROSIS, DISEASE, TRAITS, MORTALITY, CELLS, HERITABILITY, GENE-EXPRESSION, LUNG-FUNCTION, HEALTHY TWIN
journal title
NATURE GENETICS
Nature Genet.
volume
46
issue
7
pages
669 - 677
Web of Science type
Article
Web of Science id
000338093800006
JCR category
GENETICS & HEREDITY
JCR impact factor
29.352 (2014)
JCR rank
2/167 (2014)
JCR quartile
1 (2014)
ISSN
1061-4036
DOI
10.1038/ng.3011
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5771780
handle
http://hdl.handle.net/1854/LU-5771780
date created
2014-12-04 14:50:57
date last changed
2016-12-19 15:39:09
@article{5771780,
  abstract     = {Forced vital capacity (FVC), a spirometric measure of pulmonary function, reflects lung volume and is used to diagnose and monitor lung diseases. We performed genome-wide association study meta-analysis of FVC in 52,253 individuals from 26 studies and followed up the top associations in 32,917 additional individuals of European ancestry. We found six new regions associated at genome-wide significance (P {\textlangle} 5 x 10(-8)) with FVC in or near EFEMP1, BMP6, MIR129-2-HSD17B12, PRDM11, WWOX and KCNJ2. Two loci previously associated with spirometric measures (GSTCD and PTCH1) were related to FVC. Newly implicated regions were followed up in samples from African-American, Korean, Chinese and Hispanic individuals. We detected transcripts for all six newly implicated genes in human lung tissue. The new loci may inform mechanisms involved in lung development and the pathogenesis of restrictive lung disease.},
  author       = {Loth, Daan W and Artigas, Maria Soler and Gharib, Sina A and Wain, Louise V and Franceschini, Nora and Koch, Beate and Pottinger, Tess D and Smith, Albert Vernon and Duan, Qing and Oldmeadow, Chris and Lee, Mi Kyeong and Strachan, David P and James, Alan L and Huffman, Jennifer E and Vitart, Veronique and Ramasamy, Adaikalavan and Wareham, Nicholas J and Kaprio, Jaakko and Wang, Xin-Qun and Trochet, Holly and Kaonen, Mika and Flexeder, Claudia and Albrecht, Eva and Lopez, Lorna M and de Jong, Kim and Thyagarajan, Bharat and Alves, Alexessander Couto and Enroth, Stefan and Omenaas, Ernst and Joshi, Peter K and Fall, Tove and Vinuela, Ana and Launer, Lenore J and Loehr, Laura R and Fornage, Myriam and Li, Guo and Wik, Jemma B and Tang, Wenbo and Manichaikul, Ani and Lahousse, Lies and Harris, Tamara B and North, Kari E and Rudnicka, Alicja R and Hui, Jennie and Gu, Xiangjun and Lumley, Thomas and Wright, Alan F and Hastie, Nicholas D and Campbell, Susan and Kumar, Rajesh and Pin, Isabelle and Scott, Robert A and Pietilainen, Kirsi H and Surakka, Ida and Liu, Yongmei and Holliday, Elizabeth G and Schulz, Holger and Heinrich, Joachim and Davies, Gail and Vonk, Judith M and Wojczynski, Mary and Pouta, Anneli and Johansson, Asa and Wild, Sarah H and Ingelsson, Erik and Rivadeneira, Fernando and Voezke, Henry and Hysi, Pirro G and Eiriksdottir, Gudny and Morrison, Alanna C and Rotter, Jerome I and Gao, Wei and Postma, Dirkje S and White, Wendy B and Rich, Stephen S and Hofman, Albert and Aspelund, Thor and Couper, David and Smith, Lewis J and Psaty, Bruce M and Lohman, Kurt and Burchard, Esteban G and Uitterlinden, Andre G and Garcia, Melissa and Joubert, Bonnie R and McArdle, Wendy L and Musk, A Bill and Hansel, Nadia and Heckbert, Susan R and Zgaga, Lina and van Meurs, Joyce BJ and Navarro, Pau and Rudan, Igor and Oh, Yeon-Mok and Redline, Susan and Jarvis, Deborah L and Zhao, Jing Hua and Rantanen, Taina and O'Connor, George T and Ripatti, Samuli and Scott, Rodney J and Karrasch, Stefan and Grallert, Harald and Gaddis, Nathan C and Starr, John M and Wijmenga, Cisca and Minster, Ryan L and Lederer, David J and Pekkanen, Juha and Gyllensten, Ulf and Campbe, Harry and Morris, Andrew P and Glaeser, Sven and Hammond, Christopher J and Burkart, Kristin M and Beilby, John and Kritchevsky, Stephen B and Gucinason, Vilrnundur and Hancock, Dana B and Williams, Dale and Polasek, Ozren and Zemunik, Tatijana and Kolcic, Ivana and Petrini, Marcy F and Wjst, Matthias and Kim, Woo Jin and Porteous, David J and Scotland, Generation and Smith, Blair H and Villanen, Anne and Heliovaara, Markku and Attia, John R and Sayers, Ian and Hampel, Regina and Gieger, Christian and Deary, Ian J and Boezen, H Marike and Newman, Anne and Jarvelin, Marjo-Riitta and Wilson, James F and Lind, Lars and Stricker, Bruno H and Teumer, Alexander and Spector, Timothy D and Melen, Erik and Peters, Marjolein J and Lange, Leslie A and Barr, R Graham and Bracke, Ken and Verhamme, Fien and Sung, Joohon and Hiemstra, Pieter S and Cassano, Patricia A and Sood, Akshay and Hayward, Caroline and Dupuis, Josee and Hall, Ian P and Brusselle, Guy and Tobin, Martin D and London, Stephanie J},
  issn         = {1061-4036},
  journal      = {NATURE GENETICS},
  keyword      = {FAMILY,IDIOPATHIC PULMONARY-FIBROSIS,DISEASE,TRAITS,MORTALITY,CELLS,HERITABILITY,GENE-EXPRESSION,LUNG-FUNCTION,HEALTHY TWIN},
  language     = {eng},
  number       = {7},
  pages        = {669--677},
  title        = {Genome-wide association analysis identifies six new loci associated with forced vital capacity},
  url          = {http://dx.doi.org/10.1038/ng.3011},
  volume       = {46},
  year         = {2014},
}

Chicago
Loth, Daan W, Maria Soler Artigas, Sina A Gharib, Louise V Wain, Nora Franceschini, Beate Koch, Tess D Pottinger, et al. 2014. “Genome-wide Association Analysis Identifies Six New Loci Associated with Forced Vital Capacity.” Nature Genetics 46 (7): 669–677.
APA
Loth, Daan W, Artigas, M. S., Gharib, S. A., Wain, L. V., Franceschini, N., Koch, B., Pottinger, T. D., et al. (2014). Genome-wide association analysis identifies six new loci associated with forced vital capacity. NATURE GENETICS, 46(7), 669–677.
Vancouver
1.
Loth DW, Artigas MS, Gharib SA, Wain LV, Franceschini N, Koch B, et al. Genome-wide association analysis identifies six new loci associated with forced vital capacity. NATURE GENETICS. 2014;46(7):669–77.
MLA
Loth, Daan W, Maria Soler Artigas, Sina A Gharib, et al. “Genome-wide Association Analysis Identifies Six New Loci Associated with Forced Vital Capacity.” NATURE GENETICS 46.7 (2014): 669–677. Print.