Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells
- Author
- Patrícia MR Pereira, José J Carvalho, Sandrina Silva, José AS Cavaleiro, Rudolf J Schneider, Rosa Fernandes and João Tomé (UGent)
- Organization
- Abstract
- The synthesis of a novel PS conjugated with bovine and human serum albumin (BSA and HSA) and a monoclonal antibody anti-CD104 is reported, as well as their biological potential against the human bladder cancer cell line UM-UC-3. No photodynamic effect was detected when the non-conjugated porphyrin was used. Yet, when it was coupled covalently with the mAb anti-CD104, BSA and HSA, the resulting photosensitizer conjugates demonstrated high efficacy in destroying the cancer cells, the mAb anti-CD104 efficacy overruling the albumins.
- Keywords
- MEMBRANE, PHOTOIMMUNOTHERAPY, IN-VITRO, PHOTODYNAMIC THERAPY, POLY-S-LYSINE
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Citation
Please use this url to cite or link to this publication: http://hdl.handle.net/1854/LU-5768721
- MLA
- Pereira, Patrícia MR, José J Carvalho, Sandrina Silva, et al. “Porphyrin Conjugated with Serum Albumins and Monoclonal Antibodies Boosts Efficiency in Targeted Destruction of Human Bladder Cancer Cells.” ORGANIC & BIOMOLECULAR CHEMISTRY 12.11 (2014): 1804–1811. Print.
- APA
- Pereira, Patrícia MR, Carvalho, J. J., Silva, S., Cavaleiro, J. A., Schneider, R. J., Fernandes, R., & Tomé, J. (2014). Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells. ORGANIC & BIOMOLECULAR CHEMISTRY, 12(11), 1804–1811.
- Chicago author-date
- Pereira, Patrícia MR, José J Carvalho, Sandrina Silva, José AS Cavaleiro, Rudolf J Schneider, Rosa Fernandes, and João Tomé. 2014. “Porphyrin Conjugated with Serum Albumins and Monoclonal Antibodies Boosts Efficiency in Targeted Destruction of Human Bladder Cancer Cells.” Organic & Biomolecular Chemistry 12 (11): 1804–1811.
- Chicago author-date (all authors)
- Pereira, Patrícia MR, José J Carvalho, Sandrina Silva, José AS Cavaleiro, Rudolf J Schneider, Rosa Fernandes, and João Tomé. 2014. “Porphyrin Conjugated with Serum Albumins and Monoclonal Antibodies Boosts Efficiency in Targeted Destruction of Human Bladder Cancer Cells.” Organic & Biomolecular Chemistry 12 (11): 1804–1811.
- Vancouver
- 1.Pereira PM, Carvalho JJ, Silva S, Cavaleiro JA, Schneider RJ, Fernandes R, et al. Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells. ORGANIC & BIOMOLECULAR CHEMISTRY. 2014;12(11):1804–11.
- IEEE
- [1]P. M. Pereira et al., “Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells,” ORGANIC & BIOMOLECULAR CHEMISTRY, vol. 12, no. 11, pp. 1804–1811, 2014.
@article{5768721,
abstract = {The synthesis of a novel PS conjugated with bovine and human serum albumin (BSA and HSA) and a monoclonal antibody anti-CD104 is reported, as well as their biological potential against the human bladder cancer cell line UM-UC-3. No photodynamic effect was detected when the non-conjugated porphyrin was used. Yet, when it was coupled covalently with the mAb anti-CD104, BSA and HSA, the resulting photosensitizer conjugates demonstrated high efficacy in destroying the cancer cells, the mAb anti-CD104 efficacy overruling the albumins.},
author = {Pereira, Patrícia MR and Carvalho, José J and Silva, Sandrina and Cavaleiro, José AS and Schneider, Rudolf J and Fernandes, Rosa and Tomé, João},
issn = {1477-0520},
journal = {ORGANIC & BIOMOLECULAR CHEMISTRY},
keywords = {MEMBRANE,PHOTOIMMUNOTHERAPY,IN-VITRO,PHOTODYNAMIC THERAPY,POLY-S-LYSINE},
language = {eng},
number = {11},
pages = {1804--1811},
title = {Porphyrin conjugated with serum albumins and monoclonal antibodies boosts efficiency in targeted destruction of human bladder cancer cells},
url = {http://dx.doi.org/10.1039/c3ob42082e},
volume = {12},
year = {2014},
}
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