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Evaluation of sphingomyelin, cholester, and phosphatidylcholine-based immobilized artificial membrane liquid chromatography to predict drug penetration across the blood-brain barrier

Mike De Vrieze, Dieter Verzele, Roman Szucs UGent, Patrick Sandra UGent and Frederic Lynen UGent (2014) ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 406(25). p.6179-6188
abstract
Over the past decades, several in vitro methods have been tested for their ability to predict drug penetration across the blood-brain barrier. So far, in high-performance liquid chromatography, most attention has been paid to micellar liquid chromatography and immobilized artificial membrane (IAM) LC. IAMLC has been described as a viable approach, since the stationary phase emulates the lipid environment of a cell membrane. However, research in IAMLC has almost exclusively been limited to phosphatidylcholine (PC)-based stationary phases, even though PC is only one of the lipids present in cell membranes. In this article, sphingomyelin and cholester stationary phases have been tested for the first time towards their ability to predict drug penetration across the blood-brain barrier. Upon comparison with the PC stationary phase, the sphingomyelin- and cholester-based columns depict similar predictive performance. Combining data from the different stationary phases did not lead to improvements of the models.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
PARTITION, MODELS, DESCRIPTORS, RETENTION, PERMEABILITY, IN-SILICO PREDICTION, Cholester, Sphingomyelin, Phosphatidylcholine, Immobilized artificial membrane, Blood-brain barrier, Liquid chromatography
journal title
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Anal. Bioanal. Chem.
volume
406
issue
25
pages
6179 - 6188
Web of Science type
Article
Web of Science id
000342224300010
JCR category
CHEMISTRY, ANALYTICAL
JCR impact factor
3.436 (2014)
JCR rank
13/74 (2014)
JCR quartile
1 (2014)
ISSN
1618-2642
DOI
10.1007/s00216-014-8054-7
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5768496
handle
http://hdl.handle.net/1854/LU-5768496
date created
2014-12-02 13:04:38
date last changed
2016-12-19 15:47:06
@article{5768496,
  abstract     = {Over the past decades, several in vitro methods have been tested for their ability to predict drug penetration across the blood-brain barrier. So far, in high-performance liquid chromatography, most attention has been paid to micellar liquid chromatography and immobilized artificial membrane (IAM) LC. IAMLC has been described as a viable approach, since the stationary phase emulates the lipid environment of a cell membrane. However, research in IAMLC has almost exclusively been limited to phosphatidylcholine (PC)-based stationary phases, even though PC is only one of the lipids present in cell membranes. In this article, sphingomyelin and cholester stationary phases have been tested for the first time towards their ability to predict drug penetration across the blood-brain barrier. Upon comparison with the PC stationary phase, the sphingomyelin- and cholester-based columns depict similar predictive performance. Combining data from the different stationary phases did not lead to improvements of the models.},
  author       = {De Vrieze, Mike and Verzele, Dieter and Szucs, Roman and Sandra, Patrick and Lynen, Frederic},
  issn         = {1618-2642},
  journal      = {ANALYTICAL AND BIOANALYTICAL CHEMISTRY},
  keyword      = {PARTITION,MODELS,DESCRIPTORS,RETENTION,PERMEABILITY,IN-SILICO PREDICTION,Cholester,Sphingomyelin,Phosphatidylcholine,Immobilized artificial membrane,Blood-brain barrier,Liquid chromatography},
  language     = {eng},
  number       = {25},
  pages        = {6179--6188},
  title        = {Evaluation of sphingomyelin, cholester, and phosphatidylcholine-based immobilized artificial membrane liquid chromatography to predict drug penetration across the blood-brain barrier},
  url          = {http://dx.doi.org/10.1007/s00216-014-8054-7},
  volume       = {406},
  year         = {2014},
}

Chicago
De Vrieze, Mike, Dieter Verzele, Roman Szucs, Patrick Sandra, and Frederic Lynen. 2014. “Evaluation of Sphingomyelin, Cholester, and Phosphatidylcholine-based Immobilized Artificial Membrane Liquid Chromatography to Predict Drug Penetration Across the Blood-brain Barrier.” Analytical and Bioanalytical Chemistry 406 (25): 6179–6188.
APA
De Vrieze, M., Verzele, D., Szucs, R., Sandra, P., & Lynen, F. (2014). Evaluation of sphingomyelin, cholester, and phosphatidylcholine-based immobilized artificial membrane liquid chromatography to predict drug penetration across the blood-brain barrier. ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 406(25), 6179–6188.
Vancouver
1.
De Vrieze M, Verzele D, Szucs R, Sandra P, Lynen F. Evaluation of sphingomyelin, cholester, and phosphatidylcholine-based immobilized artificial membrane liquid chromatography to predict drug penetration across the blood-brain barrier. ANALYTICAL AND BIOANALYTICAL CHEMISTRY. 2014;406(25):6179–88.
MLA
De Vrieze, Mike, Dieter Verzele, Roman Szucs, et al. “Evaluation of Sphingomyelin, Cholester, and Phosphatidylcholine-based Immobilized Artificial Membrane Liquid Chromatography to Predict Drug Penetration Across the Blood-brain Barrier.” ANALYTICAL AND BIOANALYTICAL CHEMISTRY 406.25 (2014): 6179–6188. Print.