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Gender differences in the management and outcome of atrial fibrillation complicating acute heart failure

(2014) JOURNAL OF CARDIAC FAILURE. 20(6). p.431-437
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Abstract
Background: Little is known about sex differences in the prevalence, treatment, and outcome of atrial fibrillation complicating acute heart failure. Methods and Results: Among 957 patients (429 women, 528 men), included in the BIO-HF registry, 45.2% (n = 194) of the women and 45.1% (n = 238) of the men were admitted with atrial fibrillation. The primary end point was a composite of 1-year all-cause mortality and hospitalization for heart failure. Adjusted 1-year mortality and hospitalization rates were similar between sexes (women 38.5%, men 36.0%; OR for female gender: 1.1, 95% CI 0.65-1.86; P = .71. A significant interaction between female sex and age (P = .002) was observed; with worse prognosis for women <75 years (OR 7.17, 95% CI 1.79-28.66; P = .005) compared with men <75 years. No sex differences in in-hospital treatment, restoration of sinus rhythm (16.5% in women vs 14.2% in men; P = .58), or in-hospital mortality (5.7% in women vs 6.7% in men; P = .69) were observed. Conclusions: Among patients hospitalized with acute heart failure, no sex differences in the prevalence and management of atrial fibrillation were observed. In-hospital mortality and the composite of 1-year mortality and rehospitalization were not different between sexes, but a significant sex-age interaction was observed, with worse outcome in women <75 years versus men <75 years of age.
Keywords
WOMEN, IMPACT, RISK-FACTOR, SEX, MORTALITY, RETROSPECTIVE ANALYSIS, EJECTION FRACTION, RENAL DYSFUNCTION, gender, IN-HOSPITAL MANAGEMENT, QUALITY-OF-CARE, atrial fibrillation, Acute heart failure

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Chicago
Gevaert, Sofie, Dirk De Bacquer, Anne-Marie Willems, Barbara vande Kerckhove, Caroline Weytjens, Guy van Camp, and Johan De Sutter. 2014. “Gender Differences in the Management and Outcome of Atrial Fibrillation Complicating Acute Heart Failure.” Journal of Cardiac Failure 20 (6): 431–437.
APA
Gevaert, Sofie, De Bacquer, D., Willems, A.-M., vande Kerckhove, B., Weytjens, C., van Camp, G., & De Sutter, J. (2014). Gender differences in the management and outcome of atrial fibrillation complicating acute heart failure. JOURNAL OF CARDIAC FAILURE, 20(6), 431–437.
Vancouver
1.
Gevaert S, De Bacquer D, Willems A-M, vande Kerckhove B, Weytjens C, van Camp G, et al. Gender differences in the management and outcome of atrial fibrillation complicating acute heart failure. JOURNAL OF CARDIAC FAILURE. 2014;20(6):431–7.
MLA
Gevaert, Sofie, Dirk De Bacquer, Anne-Marie Willems, et al. “Gender Differences in the Management and Outcome of Atrial Fibrillation Complicating Acute Heart Failure.” JOURNAL OF CARDIAC FAILURE 20.6 (2014): 431–437. Print.
@article{5764412,
  abstract     = {Background: Little is known about sex differences in the prevalence, treatment, and outcome of atrial fibrillation complicating acute heart failure. 
Methods and Results: Among 957 patients (429 women, 528 men), included in the BIO-HF registry, 45.2\% (n = 194) of the women and 45.1\% (n = 238) of the men were admitted with atrial fibrillation. The primary end point was a composite of 1-year all-cause mortality and hospitalization for heart failure. Adjusted 1-year mortality and hospitalization rates were similar between sexes (women 38.5\%, men 36.0\%; OR for female gender: 1.1, 95\% CI 0.65-1.86; P = .71. A significant interaction between female sex and age (P = .002) was observed; with worse prognosis for women {\textlangle}75 years (OR 7.17, 95\% CI 1.79-28.66; P = .005) compared with men {\textlangle}75 years. No sex differences in in-hospital treatment, restoration of sinus rhythm (16.5\% in women vs 14.2\% in men; P = .58), or in-hospital mortality (5.7\% in women vs 6.7\% in men; P = .69) were observed. 
Conclusions: Among patients hospitalized with acute heart failure, no sex differences in the prevalence and management of atrial fibrillation were observed. In-hospital mortality and the composite of 1-year mortality and rehospitalization were not different between sexes, but a significant sex-age interaction was observed, with worse outcome in women {\textlangle}75 years versus men {\textlangle}75 years of age.},
  author       = {Gevaert, Sofie and De Bacquer, Dirk and Willems, Anne-Marie and vande Kerckhove, Barbara and Weytjens, Caroline and van Camp, Guy and De Sutter, Johan},
  issn         = {1071-9164},
  journal      = {JOURNAL OF CARDIAC FAILURE},
  keyword      = {WOMEN,IMPACT,RISK-FACTOR,SEX,MORTALITY,RETROSPECTIVE ANALYSIS,EJECTION FRACTION,RENAL DYSFUNCTION,gender,IN-HOSPITAL MANAGEMENT,QUALITY-OF-CARE,atrial fibrillation,Acute heart failure},
  language     = {eng},
  number       = {6},
  pages        = {431--437},
  title        = {Gender differences in the management and outcome of atrial fibrillation complicating acute heart failure},
  url          = {http://dx.doi.org/10.1016/j.cardfail.2014.03.004},
  volume       = {20},
  year         = {2014},
}

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