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Gender differences in the management and outcome of atrial fibrillation complicating acute heart failure

SOFIE GEVAERT, Dirk De Bacquer UGent, Anne-Marie Willems, Barbara vande Kerckhove, Caroline Weytjens, Guy van Camp and Johan De Sutter UGent (2014) JOURNAL OF CARDIAC FAILURE. 20(6). p.431-437
abstract
Background: Little is known about sex differences in the prevalence, treatment, and outcome of atrial fibrillation complicating acute heart failure. Methods and Results: Among 957 patients (429 women, 528 men), included in the BIO-HF registry, 45.2% (n = 194) of the women and 45.1% (n = 238) of the men were admitted with atrial fibrillation. The primary end point was a composite of 1-year all-cause mortality and hospitalization for heart failure. Adjusted 1-year mortality and hospitalization rates were similar between sexes (women 38.5%, men 36.0%; OR for female gender: 1.1, 95% CI 0.65-1.86; P = .71. A significant interaction between female sex and age (P = .002) was observed; with worse prognosis for women <75 years (OR 7.17, 95% CI 1.79-28.66; P = .005) compared with men <75 years. No sex differences in in-hospital treatment, restoration of sinus rhythm (16.5% in women vs 14.2% in men; P = .58), or in-hospital mortality (5.7% in women vs 6.7% in men; P = .69) were observed. Conclusions: Among patients hospitalized with acute heart failure, no sex differences in the prevalence and management of atrial fibrillation were observed. In-hospital mortality and the composite of 1-year mortality and rehospitalization were not different between sexes, but a significant sex-age interaction was observed, with worse outcome in women <75 years versus men <75 years of age.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
WOMEN, IMPACT, RISK-FACTOR, SEX, MORTALITY, RETROSPECTIVE ANALYSIS, EJECTION FRACTION, RENAL DYSFUNCTION, gender, IN-HOSPITAL MANAGEMENT, QUALITY-OF-CARE, atrial fibrillation, Acute heart failure
journal title
JOURNAL OF CARDIAC FAILURE
J. Card. Fail.
volume
20
issue
6
pages
431 - 437
Web of Science type
Article
Web of Science id
000337070900008
JCR category
CARDIAC & CARDIOVASCULAR SYSTEMS
JCR impact factor
3.051 (2014)
JCR rank
45/123 (2014)
JCR quartile
2 (2014)
ISSN
1071-9164
DOI
10.1016/j.cardfail.2014.03.004
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5764412
handle
http://hdl.handle.net/1854/LU-5764412
date created
2014-11-27 11:28:37
date last changed
2016-12-19 15:39:52
@article{5764412,
  abstract     = {Background: Little is known about sex differences in the prevalence, treatment, and outcome of atrial fibrillation complicating acute heart failure. 
Methods and Results: Among 957 patients (429 women, 528 men), included in the BIO-HF registry, 45.2\% (n = 194) of the women and 45.1\% (n = 238) of the men were admitted with atrial fibrillation. The primary end point was a composite of 1-year all-cause mortality and hospitalization for heart failure. Adjusted 1-year mortality and hospitalization rates were similar between sexes (women 38.5\%, men 36.0\%; OR for female gender: 1.1, 95\% CI 0.65-1.86; P = .71. A significant interaction between female sex and age (P = .002) was observed; with worse prognosis for women {\textlangle}75 years (OR 7.17, 95\% CI 1.79-28.66; P = .005) compared with men {\textlangle}75 years. No sex differences in in-hospital treatment, restoration of sinus rhythm (16.5\% in women vs 14.2\% in men; P = .58), or in-hospital mortality (5.7\% in women vs 6.7\% in men; P = .69) were observed. 
Conclusions: Among patients hospitalized with acute heart failure, no sex differences in the prevalence and management of atrial fibrillation were observed. In-hospital mortality and the composite of 1-year mortality and rehospitalization were not different between sexes, but a significant sex-age interaction was observed, with worse outcome in women {\textlangle}75 years versus men {\textlangle}75 years of age.},
  author       = {GEVAERT, SOFIE and De Bacquer, Dirk and Willems, Anne-Marie and vande Kerckhove, Barbara and Weytjens, Caroline and van Camp, Guy and De Sutter, Johan},
  issn         = {1071-9164},
  journal      = {JOURNAL OF CARDIAC FAILURE},
  keyword      = {WOMEN,IMPACT,RISK-FACTOR,SEX,MORTALITY,RETROSPECTIVE ANALYSIS,EJECTION FRACTION,RENAL DYSFUNCTION,gender,IN-HOSPITAL MANAGEMENT,QUALITY-OF-CARE,atrial fibrillation,Acute heart failure},
  language     = {eng},
  number       = {6},
  pages        = {431--437},
  title        = {Gender differences in the management and outcome of atrial fibrillation complicating acute heart failure},
  url          = {http://dx.doi.org/10.1016/j.cardfail.2014.03.004},
  volume       = {20},
  year         = {2014},
}

Chicago
GEVAERT, SOFIE, Dirk De Bacquer, Anne-Marie Willems, Barbara vande Kerckhove, Caroline Weytjens, Guy van Camp, and Johan De Sutter. 2014. “Gender Differences in the Management and Outcome of Atrial Fibrillation Complicating Acute Heart Failure.” Journal of Cardiac Failure 20 (6): 431–437.
APA
GEVAERT, S., De Bacquer, D., Willems, A.-M., vande Kerckhove, B., Weytjens, C., van Camp, G., & De Sutter, J. (2014). Gender differences in the management and outcome of atrial fibrillation complicating acute heart failure. JOURNAL OF CARDIAC FAILURE, 20(6), 431–437.
Vancouver
1.
GEVAERT S, De Bacquer D, Willems A-M, vande Kerckhove B, Weytjens C, van Camp G, et al. Gender differences in the management and outcome of atrial fibrillation complicating acute heart failure. JOURNAL OF CARDIAC FAILURE. 2014;20(6):431–7.
MLA
GEVAERT, SOFIE, Dirk De Bacquer, Anne-Marie Willems, et al. “Gender Differences in the Management and Outcome of Atrial Fibrillation Complicating Acute Heart Failure.” JOURNAL OF CARDIAC FAILURE 20.6 (2014): 431–437. Print.