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Ly49E Expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases

Aline Van Acker (UGent) , Jessica Filtjens (UGent) , Sophie Van Welden (UGent) , Sylvie Taveirne (UGent) , Els Van Ammel (UGent) , Mandy Vanhees (UGent) , Lindsey Devisscher (UGent) , Tessa Kerre (UGent) , Tom Taghon (UGent) , Bart Vandekerckhove (UGent) , et al.
(2014) PLOS ONE. 9(10).
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Abstract
The Ly49E NK receptor is a unique inhibitory receptor, presenting with a high degree of conservation among mouse strains and expression on both NK cells and intraepithelial-localised T cells. Amongst intraepithelial-localised T cells, the Ly49E receptor is abundantly expressed on CD8 alpha alpha-expressing innate-like intestinal intraepithelial lymphocytes (iIELs), which contribute to front-line defense at the mucosal barrier. Inflammatory bowel diseases (IBDs), encompassing Crohn's disease and ulcerative colitis, have previously been suggested to have an autoreactive origin and to evolve from a dysbalance between regulatory and effector functions in the intestinal immune system. Here, we made use of Ly49E-deficient mice to characterize the role of Ly49E receptor expression on CD8 alpha alpha-expressing iIELs in the development and progression of IBD. For this purpose we used the dextran sodium sulphate (DSS)- and trinitrobenzenesulfonic-acid (TNBS)-induced colitis models, and the TNF Delta ARE ileitis model. We show that Ly49E is expressed on a high proportion of CD8 alpha alpha-positive iIELs, with higher expression in the colon as compared to the small intestine. However, Ly49E expression on small intestinal and colonic iIELs does not influence the development or progression of inflammatory bowel diseases.
Keywords
RECOGNITION, MODULATION, PATHOGENESIS, PROTECTION, MICE, RECEPTOR, GAMMA-DELTA-T, NK CELLS, INDUCED COLITIS, CROHNS-DISEASE

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Chicago
Van Acker, Aline, Jessica Filtjens, Sophie Van Welden, Sylvie Taveirne, Els Van Ammel, Mandy Vanhees, Lindsey Devisscher, et al. 2014. “Ly49E Expression on CD8αα-expressing Intestinal Intraepithelial Lymphocytes Plays No Detectable Role in the Development and Progression of Experimentally Induced Inflammatory Bowel Diseases.” Plos One 9 (10).
APA
Van Acker, A., Filtjens, J., Van Welden, S., Taveirne, S., Van Ammel, E., Vanhees, M., Devisscher, L., et al. (2014). Ly49E Expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases. PLOS ONE, 9(10).
Vancouver
1.
Van Acker A, Filtjens J, Van Welden S, Taveirne S, Van Ammel E, Vanhees M, et al. Ly49E Expression on CD8αα-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases. PLOS ONE. 2014;9(10).
MLA
Van Acker, Aline et al. “Ly49E Expression on CD8αα-expressing Intestinal Intraepithelial Lymphocytes Plays No Detectable Role in the Development and Progression of Experimentally Induced Inflammatory Bowel Diseases.” PLOS ONE 9.10 (2014): n. pag. Print.
@article{5759097,
  abstract     = {The Ly49E NK receptor is a unique inhibitory receptor, presenting with a high degree of conservation among mouse strains and expression on both NK cells and intraepithelial-localised T cells. Amongst intraepithelial-localised T cells, the Ly49E receptor is abundantly expressed on CD8 alpha alpha-expressing innate-like intestinal intraepithelial lymphocytes (iIELs), which contribute to front-line defense at the mucosal barrier. Inflammatory bowel diseases (IBDs), encompassing Crohn's disease and ulcerative colitis, have previously been suggested to have an autoreactive origin and to evolve from a dysbalance between regulatory and effector functions in the intestinal immune system. Here, we made use of Ly49E-deficient mice to characterize the role of Ly49E receptor expression on CD8 alpha alpha-expressing iIELs in the development and progression of IBD. For this purpose we used the dextran sodium sulphate (DSS)- and trinitrobenzenesulfonic-acid (TNBS)-induced colitis models, and the TNF Delta ARE ileitis model. We show that Ly49E is expressed on a high proportion of CD8 alpha alpha-positive iIELs, with higher expression in the colon as compared to the small intestine. However, Ly49E expression on small intestinal and colonic iIELs does not influence the development or progression of inflammatory bowel diseases.},
  articleno    = {e110015},
  author       = {Van Acker, Aline and Filtjens, Jessica and Van Welden, Sophie and Taveirne, Sylvie and Van Ammel, Els and Vanhees, Mandy and Devisscher, Lindsey and Kerre, Tessa and Taghon, Tom and Vandekerckhove, Bart and Plum, Jean and Leclercq, Georges},
  issn         = {1932-6203},
  journal      = {PLOS ONE},
  language     = {eng},
  number       = {10},
  pages        = {11},
  title        = {Ly49E Expression on CD8\ensuremath{\alpha}\ensuremath{\alpha}-expressing intestinal intraepithelial lymphocytes plays no detectable role in the development and progression of experimentally induced inflammatory bowel diseases},
  url          = {http://dx.doi.org/10.1371/journal.pone.0110015},
  volume       = {9},
  year         = {2014},
}

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