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Asymmetry in prevalence of femoral but not carotid atherosclerosis

Jelle Bossuyt, Lucas Van Bortel, Tine De Backer UGent, SANDRIEN VAN DE VELDE, Majda Azermai, Patrick Segers UGent, MARC DE BUYZERE, Caroline Van daele and Ernst Rietzschel UGent (2014) JOURNAL OF HYPERTENSION. 32(7). p.1429-1434
abstract
Objective(s): Atherosclerotic disease is caused by a combination of systemic and local factors (e.g. geometry) affecting local flow conditions. In contrast to the carotid artery, at the iliac-femoral artery region, a large degree of bilateral asymmetry exists. Therefore, we aimed to determine the influence of body side on the prevalence of atherosclerosis (i.e. plaque and intima-media thickness; IMT) at the carotid and femoral arteries. Methods: Data were used from the ASKLEPIOS study, including 2524 apparently healthy individuals with a mean age of 46 years (range 35-55 years). Echographic images were obtained bilaterally of the carotid and femoral arteries. A single observer approach was used for the acquisition and quantification of plaques and IMT. Results: The carotid artery displays no significant left-right difference in IMT values nor plaque prevalence (right: 12.0 vs. left 13.3%; P - 0.18). In contrast, for the femoral artery, the IMT distribution at the right common femoral artery is more skewed (P90 right: 1.11mm, left 1.01mm; P< 0.001), which is mirrored by a significantly higher plaque prevalence (right: 21.9 vs. left: 15.7%; P< 0.001). Conclusion: In the present study, atherosclerotic lesions are more prevalent at the right than at the left femoral artery. This finding highlights the possible role of local arterial geometry in the development of atherosclerosis and underscores the importance of the choice of body side when assessing vascular health.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
atherosclerotic plaque, atherosclerosis, carotid artery, femoral artery, INTIMA-MEDIA THICKNESS, CORONARY-ARTERY-DISEASE, CARDIOVASCULAR RISK, SHEAR-STRESS, BLOOD-FLOW, PLAQUE, ULTRASOUND, EXTENT, HYPERTENSION, BIFURCATION
journal title
JOURNAL OF HYPERTENSION
J. Hypertens.
volume
32
issue
7
pages
1429 - 1434
Web of Science type
Article
Web of Science id
000337351400013
JCR category
PERIPHERAL VASCULAR DISEASE
JCR impact factor
4.72 (2014)
JCR rank
10/60 (2014)
JCR quartile
1 (2014)
ISSN
0263-6352
DOI
10.1097/HJH.0000000000000205
project
Asklepios
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5758070
handle
http://hdl.handle.net/1854/LU-5758070
date created
2014-11-19 14:04:13
date last changed
2016-12-19 15:41:00
@article{5758070,
  abstract     = {Objective(s): Atherosclerotic disease is caused by a combination of systemic and local factors (e.g. geometry) affecting local flow conditions. In contrast to the carotid artery, at the iliac-femoral artery region, a large degree of bilateral asymmetry exists. Therefore, we aimed to determine the influence of body side on the prevalence of atherosclerosis (i.e. plaque and intima-media thickness; IMT) at the carotid and femoral arteries. 
Methods: Data were used from the ASKLEPIOS study, including 2524 apparently healthy individuals with a mean age of 46 years (range 35-55 years). Echographic images were obtained bilaterally of the carotid and femoral arteries. A single observer approach was used for the acquisition and quantification of plaques and IMT. 
Results: The carotid artery displays no significant left-right difference in IMT values nor plaque prevalence (right: 12.0 vs. left 13.3\%; P - 0.18). In contrast, for the femoral artery, the IMT distribution at the right common femoral artery is more skewed (P90 right: 1.11mm, left 1.01mm; P{\textlangle} 0.001), which is mirrored by a significantly higher plaque prevalence (right: 21.9 vs. left: 15.7\%; P{\textlangle} 0.001). 
Conclusion: In the present study, atherosclerotic lesions are more prevalent at the right than at the left femoral artery. This finding highlights the possible role of local arterial geometry in the development of atherosclerosis and underscores the importance of the choice of body side when assessing vascular health.},
  author       = {Bossuyt, Jelle and Van Bortel, Lucas and De Backer, Tine and VAN DE VELDE, SANDRIEN and Azermai, Majda and Segers, Patrick and DE BUYZERE, MARC and Van daele, Caroline and Rietzschel, Ernst},
  issn         = {0263-6352},
  journal      = {JOURNAL OF HYPERTENSION},
  keyword      = {atherosclerotic plaque,atherosclerosis,carotid artery,femoral artery,INTIMA-MEDIA THICKNESS,CORONARY-ARTERY-DISEASE,CARDIOVASCULAR RISK,SHEAR-STRESS,BLOOD-FLOW,PLAQUE,ULTRASOUND,EXTENT,HYPERTENSION,BIFURCATION},
  language     = {eng},
  number       = {7},
  pages        = {1429--1434},
  title        = {Asymmetry in prevalence of femoral but not carotid atherosclerosis},
  url          = {http://dx.doi.org/10.1097/HJH.0000000000000205},
  volume       = {32},
  year         = {2014},
}

Chicago
Bossuyt, Jelle, Lucas Van Bortel, Tine De Backer, SANDRIEN VAN DE VELDE, Majda Azermai, Patrick Segers, MARC DE BUYZERE, Van daeleCaroline, and Ernst Rietzschel. 2014. “Asymmetry in Prevalence of Femoral but Not Carotid Atherosclerosis.” Journal of Hypertension 32 (7): 1429–1434.
APA
Bossuyt, J., Van Bortel, L., De Backer, T., VAN DE VELDE, S., Azermai, M., Segers, P., DE BUYZERE, M., et al. (2014). Asymmetry in prevalence of femoral but not carotid atherosclerosis. JOURNAL OF HYPERTENSION, 32(7), 1429–1434.
Vancouver
1.
Bossuyt J, Van Bortel L, De Backer T, VAN DE VELDE S, Azermai M, Segers P, et al. Asymmetry in prevalence of femoral but not carotid atherosclerosis. JOURNAL OF HYPERTENSION. 2014;32(7):1429–34.
MLA
Bossuyt, Jelle, Lucas Van Bortel, Tine De Backer, et al. “Asymmetry in Prevalence of Femoral but Not Carotid Atherosclerosis.” JOURNAL OF HYPERTENSION 32.7 (2014): 1429–1434. Print.