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Hearing loss and congenital CMV infection: a systematic review

JULIE GODERIS, Els De Leenheer UGent, Koenraad Smets UGent, Helen Van Hoecke UGent, ANNELIES KEYMEULEN and Ingeborg Dhooge UGent (2014) PEDIATRICS. 134(5). p.972-982
abstract
BACKGROUND AND OBJECTIVE: Hearing loss caused by congenital cytomegalovirus (cCMV) infection was first observed in 1964. Today cCMV is the most common cause of nonhereditary sensorineural hearing loss in childhood. Our objective was to provide an overview of the prevalence of cCMV-related hearing loss, to better define the nature of cCMV-associated hearing loss, and to investigate the importance of cCMV infection in hearing-impaired children. METHODS: Two reviewers independently used Medline and manual searches of references from eligible studies and review articles to select cohort studies on children with cCMV infection with audiological follow-up and extracted data on population characteristics and hearing outcomes. RESULTS: Thirty-seven studies were included: 10 population-based natural history studies, 14 longitudinal cohort studies, and 13 retrospective studies. The prevalence of cCMV in developed countries is 0.58% (95% confidence interval, 0.41–0.79). Among these newborns 12.6% (95% confidence interval, 10.2–16.5) will experience hearing loss: 1 out of 3 symptomatic children and 1 out of 10 asymptomatic children. Among symptomatic children, the majority have bilateral loss; among asymp- tomatic children, unilateral loss predominates. In both groups the hear- ing loss is mainly severe to profound. Hearing loss can have a delayed onset, and it is unstable, with fluctuations and progression. Among hearing-impaired children, cCMV is the causative agent in 10% to 20%. Despite strict selection criteria, some heterogeneity was found between selected studies. CONCLUSIONS: This systematic review underscores the importance of cCMV as a cause of sensorineural hearing loss in childhood.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
cytomegalovirus, congenital infection, hearing, auditory, prevalence, systematic review, symptomatic infection, DRIED BLOOD SPOTS, POLYMERASE-CHAIN-REACTION, LONGITUDINAL-FOLLOW-UP, CYTOMEGALOVIRUS DNA DETECTION, CENTRAL-NERVOUS-SYSTEM, LONG-TERM, RETROSPECTIVE DIAGNOSIS, PREEXISTING IMMUNITY, GANCICLOVIR THERAPY, BIRTH PREVALENCE
journal title
PEDIATRICS
Pediatrics
volume
134
issue
5
pages
972 - 982
Web of Science type
Article
Web of Science id
000344385900047
JCR category
PEDIATRICS
JCR impact factor
5.473 (2014)
JCR rank
4/120 (2014)
JCR quartile
1 (2014)
ISSN
0031-4005
DOI
10.1542/peds.2014-1173
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5757461
handle
http://hdl.handle.net/1854/LU-5757461
date created
2014-11-18 17:06:14
date last changed
2016-12-19 15:42:21
@article{5757461,
  abstract     = {BACKGROUND AND OBJECTIVE: Hearing loss caused by congenital cytomegalovirus (cCMV) infection was first observed in 1964. Today cCMV is the most common cause of nonhereditary sensorineural hearing loss in childhood. Our objective was to provide an overview of the prevalence of cCMV-related hearing loss, to better define the nature of cCMV-associated hearing loss, and to investigate the importance of cCMV infection in hearing-impaired children.
METHODS: Two reviewers independently used Medline and manual searches of references from eligible studies and review articles to select cohort studies on children with cCMV infection with audiological follow-up and extracted data on population characteristics and hearing outcomes.
RESULTS: Thirty-seven studies were included: 10 population-based natural history studies, 14 longitudinal cohort studies, and 13 retrospective studies. The prevalence of cCMV in developed countries is 0.58\% (95\% confidence interval, 0.41--0.79). Among these newborns 12.6\% (95\% confidence interval, 10.2--16.5) will experience hearing loss: 1 out of 3 symptomatic children and 1 out of 10 asymptomatic children. Among symptomatic children, the majority have bilateral loss; among asymp- tomatic children, unilateral loss predominates. In both groups the hear- ing loss is mainly severe to profound. Hearing loss can have a delayed onset, and it is unstable, with fluctuations and progression. Among hearing-impaired children, cCMV is the causative agent in 10\% to 20\%. Despite strict selection criteria, some heterogeneity was found between selected studies.
CONCLUSIONS: This systematic review underscores the importance of cCMV as a cause of sensorineural hearing loss in childhood.},
  author       = {GODERIS, JULIE and De Leenheer, Els and Smets, Koenraad and Van Hoecke, Helen and KEYMEULEN, ANNELIES and Dhooge, Ingeborg},
  issn         = {0031-4005},
  journal      = {PEDIATRICS},
  keyword      = {cytomegalovirus,congenital infection,hearing,auditory,prevalence,systematic review,symptomatic infection,DRIED BLOOD SPOTS,POLYMERASE-CHAIN-REACTION,LONGITUDINAL-FOLLOW-UP,CYTOMEGALOVIRUS DNA DETECTION,CENTRAL-NERVOUS-SYSTEM,LONG-TERM,RETROSPECTIVE DIAGNOSIS,PREEXISTING IMMUNITY,GANCICLOVIR THERAPY,BIRTH PREVALENCE},
  language     = {eng},
  number       = {5},
  pages        = {972--982},
  title        = {Hearing loss and congenital CMV infection: a systematic review},
  url          = {http://dx.doi.org/10.1542/peds.2014-1173},
  volume       = {134},
  year         = {2014},
}

Chicago
GODERIS, JULIE, Els De Leenheer, Koenraad Smets, Helen Van Hoecke, ANNELIES KEYMEULEN, and Ingeborg Dhooge. 2014. “Hearing Loss and Congenital CMV Infection: a Systematic Review.” Pediatrics 134 (5): 972–982.
APA
GODERIS, J., De Leenheer, E., Smets, K., Van Hoecke, H., KEYMEULEN, A., & Dhooge, I. (2014). Hearing loss and congenital CMV infection: a systematic review. PEDIATRICS, 134(5), 972–982.
Vancouver
1.
GODERIS J, De Leenheer E, Smets K, Van Hoecke H, KEYMEULEN A, Dhooge I. Hearing loss and congenital CMV infection: a systematic review. PEDIATRICS. 2014;134(5):972–82.
MLA
GODERIS, JULIE, Els De Leenheer, Koenraad Smets, et al. “Hearing Loss and Congenital CMV Infection: a Systematic Review.” PEDIATRICS 134.5 (2014): 972–982. Print.