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Glucose sensing by means of silicon photonics

Ronny Bockstaele, Eva Ryckeboer (UGent) , Nannicha Hattasan (UGent) , Yannick De Koninck (UGent) , Muhammad Muneeb (UGent) , Steven Verstuyft (UGent) , Danaë Delbeke (UGent) , Wim Bogaerts (UGent) , Günther Roelkens (UGent) and Roel Baets (UGent)
(2014) PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE). In Proceedings of SPIE 8989.
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Abstract
Diabetes is a fast growing metabolic disease, where the patients suffer from disordered glucose blood levels. Monitoring the blood glucose values in combination with extra insulin injection is currently the only therapy to keep the glucose concentration in diabetic patients under control, minimizing the long- term effects of elevated glucose concentrations and improving quality of life of the diabetic patients. Implantable sensors allow continuous glucose monitoring, offering the most reliable data to control the glucose levels. Infrared absorption spectrometers offer a non-chemical measurement method to determine the small glucose concentrations in blood serum. In this work, a spectrometer platform based on silicon photonics is presented, allowing the realization of very small glucose sensors suitable for building implantable sensors. A proof-of-concept of a spectrometer with integrated evanescent sample interface is presented, and the route towards a fully implantable spectrometer is discussed.
Keywords
Silicon Photonics, infrared spectrometer, Glucose, continuous glucose monitoring, PHOTODIODES

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Citation

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MLA
Bockstaele, Ronny, et al. “Glucose Sensing by Means of Silicon Photonics.” PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE), edited by LA Eldada et al., vol. 8989, SPIE, 2014, doi:10.1117/12.2047366.
APA
Bockstaele, R., Ryckeboer, E., Hattasan, N., De Koninck, Y., Muneeb, M., Verstuyft, S., … Baets, R. (2014). Glucose sensing by means of silicon photonics. In L. Eldada, E. Lee, & S. He (Eds.), PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE) (Vol. 8989). https://doi.org/10.1117/12.2047366
Chicago author-date
Bockstaele, Ronny, Eva Ryckeboer, Nannicha Hattasan, Yannick De Koninck, Muhammad Muneeb, Steven Verstuyft, Danaë Delbeke, Wim Bogaerts, Günther Roelkens, and Roel Baets. 2014. “Glucose Sensing by Means of Silicon Photonics.” In PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE), edited by LA Eldada, EH Lee, and S He. Vol. 8989. SPIE. https://doi.org/10.1117/12.2047366.
Chicago author-date (all authors)
Bockstaele, Ronny, Eva Ryckeboer, Nannicha Hattasan, Yannick De Koninck, Muhammad Muneeb, Steven Verstuyft, Danaë Delbeke, Wim Bogaerts, Günther Roelkens, and Roel Baets. 2014. “Glucose Sensing by Means of Silicon Photonics.” In PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE), ed by. LA Eldada, EH Lee, and S He. Vol. 8989. SPIE. doi:10.1117/12.2047366.
Vancouver
1.
Bockstaele R, Ryckeboer E, Hattasan N, De Koninck Y, Muneeb M, Verstuyft S, et al. Glucose sensing by means of silicon photonics. In: Eldada L, Lee E, He S, editors. PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE). SPIE; 2014.
IEEE
[1]
R. Bockstaele et al., “Glucose sensing by means of silicon photonics,” in PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE), San Francisco, CA, USA, 2014, vol. 8989.
@inproceedings{5756325,
  abstract     = {{Diabetes is a fast growing metabolic disease, where the patients suffer from disordered glucose blood levels. Monitoring the blood glucose values in combination with extra insulin injection is currently the only therapy to keep the glucose concentration in diabetic patients under control, minimizing the long- term effects of elevated glucose concentrations and improving quality of life of the diabetic patients. Implantable sensors allow continuous glucose monitoring, offering the most reliable data to control the glucose levels. Infrared absorption spectrometers offer a non-chemical measurement method to determine the small glucose concentrations in blood serum. In this work, a spectrometer platform based on silicon photonics is presented, allowing the realization of very small glucose sensors suitable for building implantable sensors. A proof-of-concept of a spectrometer with integrated evanescent sample interface is presented, and the route towards a fully implantable spectrometer is discussed.}},
  articleno    = {{89890P}},
  author       = {{Bockstaele, Ronny and Ryckeboer, Eva and Hattasan, Nannicha and De Koninck, Yannick and Muneeb, Muhammad and Verstuyft, Steven and Delbeke, Danaë and Bogaerts, Wim and Roelkens, Günther and Baets, Roel}},
  booktitle    = {{PROCEEDINGS OF THE SOCIETY OF PHOTO-OPTICAL INSTRUMENTATION ENGINEERS (SPIE)}},
  editor       = {{Eldada, LA and Lee, EH and He, S}},
  isbn         = {{9780819499028}},
  issn         = {{0277-786X}},
  keywords     = {{Silicon Photonics,infrared spectrometer,Glucose,continuous glucose monitoring,PHOTODIODES}},
  language     = {{eng}},
  location     = {{San Francisco, CA, USA}},
  pages        = {{8}},
  publisher    = {{SPIE}},
  title        = {{Glucose sensing by means of silicon photonics}},
  url          = {{http://dx.doi.org/10.1117/12.2047366}},
  volume       = {{8989}},
  year         = {{2014}},
}
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