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Unmasking the obligatory components of nociceptive event-related brain potentials

(2013) JOURNAL OF NEUROPHYSIOLOGY. 110(10). p.2312-2324
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Abstract
It has been hypothesized that the human cortical responses to nociceptive and nonnociceptive somatosensory inputs differ. Supporting this view, somatosensory-evoked potentials (SEPs) elicited by thermal nociceptive stimuli have been suggested to originate from areas 1 and 2 of the contralateral primary somatosensory (S1), operculo-insular, and cingulate cortices, whereas the early components of nonnociceptive SEPs mainly originate from area 3b of S1. However, to avoid producing a burn lesion, and sensitize or fatigue nociceptors, thermonociceptive SEPs are typically obtained by delivering a small number of stimuli with a large and variable interstimulus interval (ISI). In contrast, the early components of nonnociceptive SEPs are usually obtained by applying many stimuli at a rapid rate. Hence, previously reported differences between nociceptive and nonnociceptive SEPs could be due to differences in signal-to-noise ratio and/or differences in the contribution of cognitive processes related, for example, to arousal and attention. Here, using intraepidermal electrical stimulation to selectively activate A delta-nociceptors at a fast and constant 1-s ISI, we found that the nociceptive SEPs obtained with a long ISI are no longer identified, indicating that these responses are not obligatory for nociception. Furthermore, using a blind source separation, we found that, unlike the obligatory components of nonnociceptive SEPs, the obligatory components of nociceptive SEPs do not receive a significant contribution from a contralateral source possibly originating from S1. Instead, they were best explained by sources compatible with bilateral operculo-insular and/or cingulate locations. Taken together, our results indicate that the obligatory components of nociceptive and nonnociceptive SEPs are fundamentally different.
Keywords
PAIN MATRIX, CORTICAL RESPONSE, LASER-EVOKED-POTENTIALS, PRIMARY SOMATOSENSORY CORTEX, intraepidermal stimulation, laser-evoked potentials, event-related potentials, primary somatosensory cortex, nociception, pain, HUMANS, PERCEPTION, BLIND SEPARATION, NEUROPATHIC PAIN, EEG RESPONSES, STIMULI

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MLA
Mouraux, A., et al. “Unmasking the Obligatory Components of Nociceptive Event-Related Brain Potentials.” JOURNAL OF NEUROPHYSIOLOGY, vol. 110, no. 10, 2013, pp. 2312–24, doi:10.1152/jn.00137.2013.
APA
Mouraux, A., De Paepe, A., Marot, E., Plaghki, L., Iannetti, G., & Legrain, V. (2013). Unmasking the obligatory components of nociceptive event-related brain potentials. JOURNAL OF NEUROPHYSIOLOGY, 110(10), 2312–2324. https://doi.org/10.1152/jn.00137.2013
Chicago author-date
Mouraux, A, Annick De Paepe, E Marot, L Plaghki, GD Iannetti, and Valéry Legrain. 2013. “Unmasking the Obligatory Components of Nociceptive Event-Related Brain Potentials.” JOURNAL OF NEUROPHYSIOLOGY 110 (10): 2312–24. https://doi.org/10.1152/jn.00137.2013.
Chicago author-date (all authors)
Mouraux, A, Annick De Paepe, E Marot, L Plaghki, GD Iannetti, and Valéry Legrain. 2013. “Unmasking the Obligatory Components of Nociceptive Event-Related Brain Potentials.” JOURNAL OF NEUROPHYSIOLOGY 110 (10): 2312–2324. doi:10.1152/jn.00137.2013.
Vancouver
1.
Mouraux A, De Paepe A, Marot E, Plaghki L, Iannetti G, Legrain V. Unmasking the obligatory components of nociceptive event-related brain potentials. JOURNAL OF NEUROPHYSIOLOGY. 2013;110(10):2312–24.
IEEE
[1]
A. Mouraux, A. De Paepe, E. Marot, L. Plaghki, G. Iannetti, and V. Legrain, “Unmasking the obligatory components of nociceptive event-related brain potentials,” JOURNAL OF NEUROPHYSIOLOGY, vol. 110, no. 10, pp. 2312–2324, 2013.
@article{5753960,
  abstract     = {{It has been hypothesized that the human cortical responses to nociceptive and nonnociceptive somatosensory inputs differ. Supporting this view, somatosensory-evoked potentials (SEPs) elicited by thermal nociceptive stimuli have been suggested to originate from areas 1 and 2 of the contralateral primary somatosensory (S1), operculo-insular, and cingulate cortices, whereas the early components of nonnociceptive SEPs mainly originate from area 3b of S1. However, to avoid producing a burn lesion, and sensitize or fatigue nociceptors, thermonociceptive SEPs are typically obtained by delivering a small number of stimuli with a large and variable interstimulus interval (ISI). In contrast, the early components of nonnociceptive SEPs are usually obtained by applying many stimuli at a rapid rate. Hence, previously reported differences between nociceptive and nonnociceptive SEPs could be due to differences in signal-to-noise ratio and/or differences in the contribution of cognitive processes related, for example, to arousal and attention. Here, using intraepidermal electrical stimulation to selectively activate A delta-nociceptors at a fast and constant 1-s ISI, we found that the nociceptive SEPs obtained with a long ISI are no longer identified, indicating that these responses are not obligatory for nociception. Furthermore, using a blind source separation, we found that, unlike the obligatory components of nonnociceptive SEPs, the obligatory components of nociceptive SEPs do not receive a significant contribution from a contralateral source possibly originating from S1. Instead, they were best explained by sources compatible with bilateral operculo-insular and/or cingulate locations. Taken together, our results indicate that the obligatory components of nociceptive and nonnociceptive SEPs are fundamentally different.}},
  author       = {{Mouraux, A and De Paepe, Annick and Marot, E and Plaghki, L and Iannetti, GD and Legrain, Valéry}},
  issn         = {{0022-3077}},
  journal      = {{JOURNAL OF NEUROPHYSIOLOGY}},
  keywords     = {{PAIN MATRIX,CORTICAL RESPONSE,LASER-EVOKED-POTENTIALS,PRIMARY SOMATOSENSORY CORTEX,intraepidermal stimulation,laser-evoked potentials,event-related potentials,primary somatosensory cortex,nociception,pain,HUMANS,PERCEPTION,BLIND SEPARATION,NEUROPATHIC PAIN,EEG RESPONSES,STIMULI}},
  language     = {{eng}},
  number       = {{10}},
  pages        = {{2312--2324}},
  title        = {{Unmasking the obligatory components of nociceptive event-related brain potentials}},
  url          = {{http://doi.org/10.1152/jn.00137.2013}},
  volume       = {{110}},
  year         = {{2013}},
}

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