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Hippocampal deep brain stimulation reduces glucose utilization in the healthy rat brain

Nathalie Van Den Berge, Vincent Keereman, Christian Vanhove UGent, Bregt Van Nieuwenhuyse, Pieter van Mierlo UGent, Robrecht Raedt UGent, Kristl Vonck UGent, Paul Boon UGent and Roel Van Holen UGent (2015) MOLECULAR IMAGING AND BIOLOGY. 17(3). p.373-383
abstract
The effects of deep brain stimulation (DBS) have been studied primarily by cellular studies, which lack the ability to elucidate DBS-related responses on a whole-brain scale. 2-Deoxy-2-[F-18]fluoro-d-glucose positron emission tomography ([F-18]FDG-PET) reflects changes in neural activity throughout the entire brain volume. The aim of this study was to investigate the whole-brain effect of DBS on the glucose utilization in healthy rats. Seven rats were implanted with a DBS electrode in the right hippocampus and injected with [F-18]FDG to measure the glucose metabolism during DBS. Analysis reveals significant DBS-induced decreases in the glucose metabolism in the bilateral hippocampus and other limbic structures. This study demonstrates that DBS exhibits not only a local effect around the electrode tip but also in other limbic regions. [F-18]FDG-PET studies have the potential to provide better insight into the mechanism of action of DBS by simultaneously observing activity at multiple sites in the brain.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Deep brain stimulation, Hippocampus, [F-18]FDG-PET, Healthy rat brain, SUBTHALAMIC NUCLEUS STIMULATION, OBSESSIVE-COMPULSIVE DISORDER, HIGH-FREQUENCY STIMULATION, TEMPORAL-LOBE EPILEPSY, ELECTRICAL-STIMULATION, PARKINSONS-DISEASE, ENERGY-METABOLISM, NETWORK MODULATION, SEIZURES, PET
journal title
MOLECULAR IMAGING AND BIOLOGY
Mol. Imaging. Biol.
volume
17
issue
3
pages
373 - 383
Web of Science type
Article
Web of Science id
000354097400010
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
2.569 (2015)
JCR rank
38/124 (2015)
JCR quartile
2 (2015)
ISSN
1536-1632
DOI
10.1007/s11307-014-0801-9
project
The integrative neuroscience of behavioral control (Neuroscience)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5752239
handle
http://hdl.handle.net/1854/LU-5752239
date created
2014-11-07 16:43:07
date last changed
2016-12-19 15:39:50
@article{5752239,
  abstract     = {The effects of deep brain stimulation (DBS) have been studied primarily by cellular studies, which lack the ability to elucidate DBS-related responses on a whole-brain scale. 2-Deoxy-2-[F-18]fluoro-d-glucose positron emission tomography ([F-18]FDG-PET) reflects changes in neural activity throughout the entire brain volume. The aim of this study was to investigate the whole-brain effect of DBS on the glucose utilization in healthy rats. 
Seven rats were implanted with a DBS electrode in the right hippocampus and injected with [F-18]FDG to measure the glucose metabolism during DBS. 
Analysis reveals significant DBS-induced decreases in the glucose metabolism in the bilateral hippocampus and other limbic structures. 
This study demonstrates that DBS exhibits not only a local effect around the electrode tip but also in other limbic regions. [F-18]FDG-PET studies have the potential to provide better insight into the mechanism of action of DBS by simultaneously observing activity at multiple sites in the brain.},
  author       = {Van Den Berge, Nathalie and Keereman, Vincent and Vanhove, Christian and Van Nieuwenhuyse, Bregt and van Mierlo, Pieter and Raedt, Robrecht and Vonck, Kristl and Boon, Paul and Van Holen, Roel},
  issn         = {1536-1632},
  journal      = {MOLECULAR IMAGING AND BIOLOGY},
  keyword      = {Deep brain stimulation,Hippocampus,[F-18]FDG-PET,Healthy rat brain,SUBTHALAMIC NUCLEUS STIMULATION,OBSESSIVE-COMPULSIVE DISORDER,HIGH-FREQUENCY STIMULATION,TEMPORAL-LOBE EPILEPSY,ELECTRICAL-STIMULATION,PARKINSONS-DISEASE,ENERGY-METABOLISM,NETWORK MODULATION,SEIZURES,PET},
  language     = {eng},
  number       = {3},
  pages        = {373--383},
  title        = {Hippocampal deep brain stimulation reduces glucose utilization in the healthy rat brain},
  url          = {http://dx.doi.org/10.1007/s11307-014-0801-9},
  volume       = {17},
  year         = {2015},
}

Chicago
Van Den Berge, Nathalie, Vincent Keereman, Christian Vanhove, Bregt Van Nieuwenhuyse, Pieter van Mierlo, Robrecht Raedt, Kristl Vonck, Paul Boon, and Roel Van Holen. 2015. “Hippocampal Deep Brain Stimulation Reduces Glucose Utilization in the Healthy Rat Brain.” Molecular Imaging and Biology 17 (3): 373–383.
APA
Van Den Berge, N., Keereman, V., Vanhove, C., Van Nieuwenhuyse, B., van Mierlo, P., Raedt, R., Vonck, K., et al. (2015). Hippocampal deep brain stimulation reduces glucose utilization in the healthy rat brain. MOLECULAR IMAGING AND BIOLOGY, 17(3), 373–383.
Vancouver
1.
Van Den Berge N, Keereman V, Vanhove C, Van Nieuwenhuyse B, van Mierlo P, Raedt R, et al. Hippocampal deep brain stimulation reduces glucose utilization in the healthy rat brain. MOLECULAR IMAGING AND BIOLOGY. 2015;17(3):373–83.
MLA
Van Den Berge, Nathalie, Vincent Keereman, Christian Vanhove, et al. “Hippocampal Deep Brain Stimulation Reduces Glucose Utilization in the Healthy Rat Brain.” MOLECULAR IMAGING AND BIOLOGY 17.3 (2015): 373–383. Print.