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Stability of generic brands of meropenem reconstituted in isotonic saline

Mieke Carlier (UGent) , Veronique Stove (UGent) , Alain Verstraete (UGent) and Jan De Waele (UGent)
(2015) MINERVA ANESTESIOLOGICA. 81(3). p.283-287
Author
Organization
Abstract
Background. Meropenem is a relatively unstable compound when dissolved. Currently, all available data have been derived from tests on the original product from Astrazeneca, and it is unsure if these data can be extrapolated to the stability of other commercially available vials. The aim of this study was therefore to assess the stability of four different brands of meropenem to be used as a prolonged or continuous infusion. Methods. Commercially available meropenem vials were reconstituted and mixed with 0.9% sodium chloride to produce solutions with concentrations of 10.20 and 40 mg/mL in polypropylene syringes, which were kept at 25 degrees C. Samples were taken immediately after preparation and up to 12 hours. Solutions retaining >90% of the initial concentration were considered stable. Results. The stability was concentration-dependent. At 25 degrees C, all 10 and 20 mg/mL solutions were stable for 12 hours in 0.9% sodium chloride, while the 40 mg/mL solutions were stable for a maximum of 8 hours. Stability of the different vials of meropenem was comparable for the time period tested (related samples Friedman's two way of analysis of variance by ranks, P=0.282). Conclusion. All tested commercially available vials of meropenem in a concentration of 10 and 20 mg/mL were stable for 12 hours at 25 degrees C when diluted in 0.9% sodium chloride. The 40 mg/mL solutions were stable for a maximum of 8 hours. This report is the first to show equivalent stability between different commercially available vials of meropenem.
Keywords
IMIPENEM, INFECTIONS, PUMPS, Polypropylene, Anti-bacterial agents, Sodium chloride, Meropenem, BETA-LACTAM ANTIBIOTICS, CONTINUOUS-INFUSION, DORIPENEM, CYSTIC-FIBROSIS

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MLA
Carlier, Mieke, Veronique Stove, Alain Verstraete, et al. “Stability of Generic Brands of Meropenem Reconstituted in Isotonic Saline.” MINERVA ANESTESIOLOGICA 81.3 (2015): 283–287. Print.
APA
Carlier, Mieke, Stove, V., Verstraete, A., & De Waele, J. (2015). Stability of generic brands of meropenem reconstituted in isotonic saline. MINERVA ANESTESIOLOGICA, 81(3), 283–287.
Chicago author-date
Carlier, Mieke, Veronique Stove, Alain Verstraete, and Jan De Waele. 2015. “Stability of Generic Brands of Meropenem Reconstituted in Isotonic Saline.” Minerva Anestesiologica 81 (3): 283–287.
Chicago author-date (all authors)
Carlier, Mieke, Veronique Stove, Alain Verstraete, and Jan De Waele. 2015. “Stability of Generic Brands of Meropenem Reconstituted in Isotonic Saline.” Minerva Anestesiologica 81 (3): 283–287.
Vancouver
1.
Carlier M, Stove V, Verstraete A, De Waele J. Stability of generic brands of meropenem reconstituted in isotonic saline. MINERVA ANESTESIOLOGICA. 2015;81(3):283–7.
IEEE
[1]
M. Carlier, V. Stove, A. Verstraete, and J. De Waele, “Stability of generic brands of meropenem reconstituted in isotonic saline,” MINERVA ANESTESIOLOGICA, vol. 81, no. 3, pp. 283–287, 2015.
@article{5742433,
  abstract     = {Background. Meropenem is a relatively unstable compound when dissolved. Currently, all available data have been derived from tests on the original product from Astrazeneca, and it is unsure if these data can be extrapolated to the stability of other commercially available vials. The aim of this study was therefore to assess the stability of four different brands of meropenem to be used as a prolonged or continuous infusion. 
Methods. Commercially available meropenem vials were reconstituted and mixed with 0.9% sodium chloride to produce solutions with concentrations of 10.20 and 40 mg/mL in polypropylene syringes, which were kept at 25 degrees C. Samples were taken immediately after preparation and up to 12 hours. Solutions retaining >90% of the initial concentration were considered stable. 
Results. The stability was concentration-dependent. At 25 degrees C, all 10 and 20 mg/mL solutions were stable for 12 hours in 0.9% sodium chloride, while the 40 mg/mL solutions were stable for a maximum of 8 hours. Stability of the different vials of meropenem was comparable for the time period tested (related samples Friedman's two way of analysis of variance by ranks, P=0.282). 
Conclusion. All tested commercially available vials of meropenem in a concentration of 10 and 20 mg/mL were stable for 12 hours at 25 degrees C when diluted in 0.9% sodium chloride. The 40 mg/mL solutions were stable for a maximum of 8 hours. This report is the first to show equivalent stability between different commercially available vials of meropenem.},
  author       = {Carlier, Mieke and Stove, Veronique and Verstraete, Alain and De Waele, Jan},
  issn         = {0375-9393},
  journal      = {MINERVA ANESTESIOLOGICA},
  keywords     = {IMIPENEM,INFECTIONS,PUMPS,Polypropylene,Anti-bacterial agents,Sodium chloride,Meropenem,BETA-LACTAM ANTIBIOTICS,CONTINUOUS-INFUSION,DORIPENEM,CYSTIC-FIBROSIS},
  language     = {eng},
  number       = {3},
  pages        = {283--287},
  title        = {Stability of generic brands of meropenem reconstituted in isotonic saline},
  volume       = {81},
  year         = {2015},
}

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