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Absence of viable HCC in the native liver is an independent protective factor of tumor recurrence after liver transplantation

(2014) TRANSPLANTATION. 97(2). p.220-226
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Abstract
Background: Prognostic factors for hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) are still a matter of debate. The absence of viable tumor in the native liver, due to effectiveness of pre-LT locoregional treatment or liver resection, is an intriguing prognostic factor that had never been evaluated. Methods: Between November 2000 and December 2011, 210 LTs were performed in patients with evidence of HCC and cirrhosis. Results: Fifty-three (25.2%) patients did not show any evidence of active residual HCC in the native liver (Group NVH), whereas 157 (74.8%) patients showed viable HCC (Group VH). All patients in Group NVH were treated before LT with a multimodal approach combining transarterial chemoembolization, liver resection, radiofrequency ablation, percutaneous ethanol injection, or sorafenib, whereas, in Group VH, 110 of the 157 (70.1%) patients received bridging therapy (P<0.001). HCC recurrence occurred in none of the patients in Group NVH (0%) and in 25 (15.9%) patients in Group VH (P=0.003). Liver resection was the most effective treatment in obtaining absence of HCC on liver explantation. The results of multivariate analysis showed that existence of pathologic HCC findings outside of the University of California-San Francisco criteria (P=0.001; odds ratio, 4; confidence interval, 1.7-9.2) and the presence of viable HCC (P=0.003; odds ratio, 5.9; confidence interval, 1.5-17.6) were independently associated with HCC recurrence. Conclusions: The histologic absence of viable HCC in the native liver after LT and morphologic criteria, due to the high effectiveness of pre-LT bridging treatments, is a highly positive prognostic factor against HCC recurrence after LT.
Keywords
Viable tumor, NECROSIS, HEPATOCELLULAR-CARCINOMA, CHEMOEMBOLIZATION, Hepatocellular carcinoma, Liver transplantation

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Citation

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MLA
Montalti, Roberto, Antonio Mimmo, Gianluca Rompianesi, et al. “Absence of Viable HCC in the Native Liver Is an Independent Protective Factor of Tumor Recurrence After Liver Transplantation.” TRANSPLANTATION 97.2 (2014): 220–226. Print.
APA
Montalti, R., Mimmo, A., Rompianesi, G., Di Gregorio, C., Serra, V., Cautero, N., Ballarin, R., et al. (2014). Absence of viable HCC in the native liver is an independent protective factor of tumor recurrence after liver transplantation. TRANSPLANTATION, 97(2), 220–226.
Chicago author-date
Montalti, Roberto, Antonio Mimmo, Gianluca Rompianesi, Carmela Di Gregorio, Valentina Serra, Nicola Cautero, Roberto Ballarin, et al. 2014. “Absence of Viable HCC in the Native Liver Is an Independent Protective Factor of Tumor Recurrence After Liver Transplantation.” Transplantation 97 (2): 220–226.
Chicago author-date (all authors)
Montalti, Roberto, Antonio Mimmo, Gianluca Rompianesi, Carmela Di Gregorio, Valentina Serra, Nicola Cautero, Roberto Ballarin, Mario Spaggiari, Giuseppe Tarantino, Giuseppe D’Amico, Mario De Santis, Lesley De Pietri, Roberto Troisi, Giorgio E Gerunda, and Fabrizio Di Benedetto. 2014. “Absence of Viable HCC in the Native Liver Is an Independent Protective Factor of Tumor Recurrence After Liver Transplantation.” Transplantation 97 (2): 220–226.
Vancouver
1.
Montalti R, Mimmo A, Rompianesi G, Di Gregorio C, Serra V, Cautero N, et al. Absence of viable HCC in the native liver is an independent protective factor of tumor recurrence after liver transplantation. TRANSPLANTATION. 2014;97(2):220–6.
IEEE
[1]
R. Montalti et al., “Absence of viable HCC in the native liver is an independent protective factor of tumor recurrence after liver transplantation,” TRANSPLANTATION, vol. 97, no. 2, pp. 220–226, 2014.
@article{5738488,
  abstract     = {{Background: Prognostic factors for hepatocellular carcinoma (HCC) recurrence after liver transplantation (LT) are still a matter of debate. The absence of viable tumor in the native liver, due to effectiveness of pre-LT locoregional treatment or liver resection, is an intriguing prognostic factor that had never been evaluated. 
Methods: Between November 2000 and December 2011, 210 LTs were performed in patients with evidence of HCC and cirrhosis. 
Results: Fifty-three (25.2%) patients did not show any evidence of active residual HCC in the native liver (Group NVH), whereas 157 (74.8%) patients showed viable HCC (Group VH). All patients in Group NVH were treated before LT with a multimodal approach combining transarterial chemoembolization, liver resection, radiofrequency ablation, percutaneous ethanol injection, or sorafenib, whereas, in Group VH, 110 of the 157 (70.1%) patients received bridging therapy (P<0.001). HCC recurrence occurred in none of the patients in Group NVH (0%) and in 25 (15.9%) patients in Group VH (P=0.003). Liver resection was the most effective treatment in obtaining absence of HCC on liver explantation. The results of multivariate analysis showed that existence of pathologic HCC findings outside of the University of California-San Francisco criteria (P=0.001; odds ratio, 4; confidence interval, 1.7-9.2) and the presence of viable HCC (P=0.003; odds ratio, 5.9; confidence interval, 1.5-17.6) were independently associated with HCC recurrence. 
Conclusions: The histologic absence of viable HCC in the native liver after LT and morphologic criteria, due to the high effectiveness of pre-LT bridging treatments, is a highly positive prognostic factor against HCC recurrence after LT.}},
  author       = {{Montalti, Roberto and Mimmo, Antonio and Rompianesi, Gianluca and Di Gregorio, Carmela and Serra, Valentina and Cautero, Nicola and Ballarin, Roberto and Spaggiari, Mario and Tarantino, Giuseppe and D'Amico, Giuseppe and De Santis, Mario and De Pietri, Lesley and Troisi, Roberto and Gerunda, Giorgio E and Di Benedetto, Fabrizio}},
  issn         = {{0041-1337}},
  journal      = {{TRANSPLANTATION}},
  keywords     = {{Viable tumor,NECROSIS,HEPATOCELLULAR-CARCINOMA,CHEMOEMBOLIZATION,Hepatocellular carcinoma,Liver transplantation}},
  language     = {{eng}},
  number       = {{2}},
  pages        = {{220--226}},
  title        = {{Absence of viable HCC in the native liver is an independent protective factor of tumor recurrence after liver transplantation}},
  url          = {{http://dx.doi.org/10.1097/TP.0b013e3182a8607e}},
  volume       = {{97}},
  year         = {{2014}},
}

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