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Matrix systems for siRNA delivery

Broes Naeye, Koen Raemdonck (UGent) , Katrien Remaut (UGent) , Jo Demeester (UGent) and Stefaan De Smedt (UGent)
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Abstract
Over the last decade, considerable effort has been put in the implementation of RNA interference (RNAi) as a treatment for various disorders. As RNAi occurs in the cytoplasm of cells, it is imperative that RNAi mediators such as small interfering RNA (siRNA) cross several extracellular and intracellular barriers to reach this site of action. Among the extensive range of proposed delivery systems for siRNA, matrix systems possess interesting properties to promote the delivery of siRNA to a target tissue. In this review, a number of recently developed matrix and hybrid systems for siRNA delivery are discussed.
Keywords
CLINICAL-APPLICATION, MAMMALIAN-CELLS, CHEMICAL-MODIFICATION, POLYMERIC NANOPARTICLES, IN-VIVO DELIVERY, DRUG-DELIVERY, OCULAR NEOVASCULARIZATION, GENE-THERAPY, MEDIATE RNA INTERFERENCE, DENDRITIC CELL SUBSETS, siRNA, RNAi, nanogel, microgel, matrix, hybrid, delivery

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Citation

Please use this url to cite or link to this publication:

MLA
Naeye, Broes, Koen Raemdonck, Katrien Remaut, et al. “Matrix Systems for siRNA Delivery.” CURRENT TOPICS IN MEDICINAL CHEMISTRY 12.2 (2012): 89–96. Print.
APA
Naeye, B., Raemdonck, K., Remaut, K., Demeester, J., & De Smedt, S. (2012). Matrix systems for siRNA delivery. CURRENT TOPICS IN MEDICINAL CHEMISTRY, 12(2), 89–96.
Chicago author-date
Naeye, Broes, Koen Raemdonck, Katrien Remaut, Jo Demeester, and Stefaan De Smedt. 2012. “Matrix Systems for siRNA Delivery.” Current Topics in Medicinal Chemistry 12 (2): 89–96.
Chicago author-date (all authors)
Naeye, Broes, Koen Raemdonck, Katrien Remaut, Jo Demeester, and Stefaan De Smedt. 2012. “Matrix Systems for siRNA Delivery.” Current Topics in Medicinal Chemistry 12 (2): 89–96.
Vancouver
1.
Naeye B, Raemdonck K, Remaut K, Demeester J, De Smedt S. Matrix systems for siRNA delivery. CURRENT TOPICS IN MEDICINAL CHEMISTRY. 2012;12(2):89–96.
IEEE
[1]
B. Naeye, K. Raemdonck, K. Remaut, J. Demeester, and S. De Smedt, “Matrix systems for siRNA delivery,” CURRENT TOPICS IN MEDICINAL CHEMISTRY, vol. 12, no. 2, pp. 89–96, 2012.
@article{5735671,
  abstract     = {Over the last decade, considerable effort has been put in the implementation of RNA interference (RNAi) as a treatment for various disorders. As RNAi occurs in the cytoplasm of cells, it is imperative that RNAi mediators such as small interfering RNA (siRNA) cross several extracellular and intracellular barriers to reach this site of action. Among the extensive range of proposed delivery systems for siRNA, matrix systems possess interesting properties to promote the delivery of siRNA to a target tissue. In this review, a number of recently developed matrix and hybrid systems for siRNA delivery are discussed.},
  author       = {Naeye, Broes and Raemdonck, Koen and Remaut, Katrien and Demeester, Jo and De Smedt, Stefaan},
  issn         = {1568-0266},
  journal      = {CURRENT TOPICS IN MEDICINAL CHEMISTRY},
  keywords     = {CLINICAL-APPLICATION,MAMMALIAN-CELLS,CHEMICAL-MODIFICATION,POLYMERIC NANOPARTICLES,IN-VIVO DELIVERY,DRUG-DELIVERY,OCULAR NEOVASCULARIZATION,GENE-THERAPY,MEDIATE RNA INTERFERENCE,DENDRITIC CELL SUBSETS,siRNA,RNAi,nanogel,microgel,matrix,hybrid,delivery},
  language     = {eng},
  number       = {2},
  pages        = {89--96},
  title        = {Matrix systems for siRNA delivery},
  volume       = {12},
  year         = {2012},
}

Web of Science
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