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Potential of methyl fluoride as a universal reaction gas to overcome spectral interference in the determination of ultratrace concentrations of metals in biofluids using inductively coupled plasma-tandem mass spectrometry

(2014) ANALYTICAL CHEMISTRY. 86(15). p.7969-7977
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Abstract
Methyl fluoride (a mixture of 10% CH3F and 90% of He) was evaluated as a reaction gas in inductively coupled plasma-tandem mass spectrometry (ICPMS/MS) in the context of the determination of ultratrace concentrations of medically relevant metals (Al, Co, Cr, Mn, Ni, Ti, and V) in blood serum and urine. Via product ion scanning, whereby only ions of the mass-to-charge ratio of the target nuclide were admitted into the octopole reaction cell, the various reaction product ions formed for each of the target elements were identified at different CH3F gas flow rates. Limits of detection (LODs) and of quantification (LOQs) and linearity of the calibration curve were documented under (i) optimized ICPMS/MS conditions for single-element monitoring and (ii) compromise conditions, allowing for multielement determination. Even under compromise settings, instrumental LODs were below 10 ng/L for all target elements, while the use of CH3F provided interference-free conditions for their determination in the biofluids of interest. Quantitative data obtained for Seronorm blood serum and urine reference materials were in excellent agreement with the corresponding reference values and/or results obtained using double-focusing sector-field ICPMS (for those elements for which no certified values were available or that were affected during reconstitution), proving the potential of this reaction gas for multielement ultratrace analysis via ICPMS/MS.
Keywords
ICP-DRC-MS, ATOMIC-ABSORPTION-SPECTROMETRY, DYNAMIC REACTION CELL, ION-MOLECULE REACTIONS, HEXAPOLE COLLISION, WHOLE-BLOOD, ISOBARIC INTERFERENCES, BIOLOGICAL SAMPLES, REACTION CHEMISTRY, TRANSITION-METAL

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Citation

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Chicago
Bolea Fernandez, Eduardo, Lieve Balcaen, Martín Resano, and Frank Vanhaecke. 2014. “Potential of Methyl Fluoride as a Universal Reaction Gas to Overcome Spectral Interference in the Determination of Ultratrace Concentrations of Metals in Biofluids Using Inductively Coupled Plasma-tandem Mass Spectrometry.” Analytical Chemistry 86 (15): 7969–7977.
APA
Bolea Fernandez, E., Balcaen, L., Resano, M., & Vanhaecke, F. (2014). Potential of methyl fluoride as a universal reaction gas to overcome spectral interference in the determination of ultratrace concentrations of metals in biofluids using inductively coupled plasma-tandem mass spectrometry. ANALYTICAL CHEMISTRY, 86(15), 7969–7977.
Vancouver
1.
Bolea Fernandez E, Balcaen L, Resano M, Vanhaecke F. Potential of methyl fluoride as a universal reaction gas to overcome spectral interference in the determination of ultratrace concentrations of metals in biofluids using inductively coupled plasma-tandem mass spectrometry. ANALYTICAL CHEMISTRY. 2014;86(15):7969–77.
MLA
Bolea Fernandez, Eduardo, Lieve Balcaen, Martín Resano, et al. “Potential of Methyl Fluoride as a Universal Reaction Gas to Overcome Spectral Interference in the Determination of Ultratrace Concentrations of Metals in Biofluids Using Inductively Coupled Plasma-tandem Mass Spectrometry.” ANALYTICAL CHEMISTRY 86.15 (2014): 7969–7977. Print.
@article{5734225,
  abstract     = {Methyl fluoride (a mixture of 10\% CH3F and 90\% of He) was evaluated as a reaction gas in inductively coupled plasma-tandem mass spectrometry (ICPMS/MS) in the context of the determination of ultratrace concentrations of medically relevant metals (Al, Co, Cr, Mn, Ni, Ti, and V) in blood serum and urine. Via product ion scanning, whereby only ions of the mass-to-charge ratio of the target nuclide were admitted into the octopole reaction cell, the various reaction product ions formed for each of the target elements were identified at different CH3F gas flow rates. Limits of detection (LODs) and of quantification (LOQs) and linearity of the calibration curve were documented under (i) optimized ICPMS/MS conditions for single-element monitoring and (ii) compromise conditions, allowing for multielement determination. Even under compromise settings, instrumental LODs were below 10 ng/L for all target elements, while the use of CH3F provided interference-free conditions for their determination in the biofluids of interest. Quantitative data obtained for Seronorm blood serum and urine reference materials were in excellent agreement with the corresponding reference values and/or results obtained using double-focusing sector-field ICPMS (for those elements for which no certified values were available or that were affected during reconstitution), proving the potential of this reaction gas for multielement ultratrace analysis via ICPMS/MS.},
  author       = {Bolea Fernandez, Eduardo and Balcaen, Lieve and Resano, Mart{\'i}n and Vanhaecke, Frank},
  issn         = {0003-2700},
  journal      = {ANALYTICAL CHEMISTRY},
  keyword      = {ICP-DRC-MS,ATOMIC-ABSORPTION-SPECTROMETRY,DYNAMIC REACTION CELL,ION-MOLECULE REACTIONS,HEXAPOLE COLLISION,WHOLE-BLOOD,ISOBARIC INTERFERENCES,BIOLOGICAL SAMPLES,REACTION CHEMISTRY,TRANSITION-METAL},
  language     = {eng},
  number       = {15},
  pages        = {7969--7977},
  title        = {Potential of methyl fluoride as a universal reaction gas to overcome spectral interference in the determination of ultratrace concentrations of metals in biofluids using inductively coupled plasma-tandem mass spectrometry},
  url          = {http://dx.doi.org/10.1021/ac502023h},
  volume       = {86},
  year         = {2014},
}

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