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RAGE limits regeneration after massive liver injury by coordinated suppression TNF-α and NF-κB

(2005) JOURNAL OF EXPERIMENTAL MEDICINE. 201(3). p.473-484
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Organization
Abstract
The exquisite ability of the liver to regenerate is finite. Identification of mechanisms that limit regeneration after massive injury holds the key to expanding the limits of liver transplantation and salvaging livers and hosts overwhelmed by carcinoma and toxic insults. Receptor for advanced glycation endproducts (RAGE) is up-regulated in liver remnants selectively after massive (85%) versus partial (70%) hepatectomy, principally in mononuclear phagocyte-derived dendritic cells (MPDDCs) Blockade of RAGE, using pharmacological antagonists or transgenic mice in which a signaling-deficient RAGE mutant is expressed in cells of mononuclear phagocyte lineage, significantly increases survival after massive liver resection. In the first hours after massive resection, remnants retrieved from RAGE-blocked mice displayed increased activated NF-kappaB principally in hepatocytes, and enhanced expression of regeneration-promoting cytokines, TNF-alpha and IL-6 and the antiinflammatory cytokine, IL-10. Hepatocyte proliferation was increased by RAGE blockade, in parallel with significantly reduced apoptosis. These data highlight central roles for RAGE and MPDCCs in modulation of cell death-promoting mechanisms in massive hepatectomy and suggest that RAGE blockade is a novel strategy to promote regeneration in the massively injured liver.
Keywords
NECROSIS-FACTOR-ALPHA, GLYCATION END-PRODUCTS, HEPATOCYTE GROWTH-FACTOR, INTERLEUKIN-6-DEFICIENT MICE, PARTIAL-HEPATECTOMY, SIGNALING PATHWAYS, DENDRITIC CELLS, CYCLIN D1, RECEPTOR, ACTIVATION

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MLA
Cataldegirmen, Guellue et al. “RAGE Limits Regeneration After Massive Liver Injury by Coordinated Suppression TNF-α and NF-κB.” JOURNAL OF EXPERIMENTAL MEDICINE 201.3 (2005): 473–484. Print.
APA
Cataldegirmen, G., Zeng, S., Feirt, N., Ippagunta, N., Dun, H., Qu, W., Lu, Y., et al. (2005). RAGE limits regeneration after massive liver injury by coordinated suppression TNF-α and NF-κB. JOURNAL OF EXPERIMENTAL MEDICINE, 201(3), 473–484.
Chicago author-date
Cataldegirmen, Guellue, Shan Zeng, Nikki Feirt, Nikalesh Ippagunta, Hao Dun, Wu Qu, Yan Lu, et al. 2005. “RAGE Limits Regeneration After Massive Liver Injury by Coordinated Suppression TNF-α and NF-κB.” Journal of Experimental Medicine 201 (3): 473–484.
Chicago author-date (all authors)
Cataldegirmen, Guellue, Shan Zeng, Nikki Feirt, Nikalesh Ippagunta, Hao Dun, Wu Qu, Yan Lu, Ling Ling Rong, Marion A Hofmann, Thomas Kislinger, Sophia I Pachydaki, Daniel G Jenkins, Alan Weinberg, Jay Lefkowitch, Xavier Rogiers, Shi Fang Yan, Ann Marie Schmidt, and Jean C Emond. 2005. “RAGE Limits Regeneration After Massive Liver Injury by Coordinated Suppression TNF-α and NF-κB.” Journal of Experimental Medicine 201 (3): 473–484.
Vancouver
1.
Cataldegirmen G, Zeng S, Feirt N, Ippagunta N, Dun H, Qu W, et al. RAGE limits regeneration after massive liver injury by coordinated suppression TNF-α and NF-κB. JOURNAL OF EXPERIMENTAL MEDICINE. 2005;201(3):473–84.
IEEE
[1]
G. Cataldegirmen et al., “RAGE limits regeneration after massive liver injury by coordinated suppression TNF-α and NF-κB,” JOURNAL OF EXPERIMENTAL MEDICINE, vol. 201, no. 3, pp. 473–484, 2005.
@article{5734020,
  abstract     = {The exquisite ability of the liver to regenerate is finite. Identification of mechanisms that limit regeneration after massive injury holds the key to expanding the limits of liver transplantation and salvaging livers and hosts overwhelmed by carcinoma and toxic insults. Receptor for advanced glycation endproducts (RAGE) is up-regulated in liver remnants selectively after massive (85%) versus partial (70%) hepatectomy, principally in mononuclear phagocyte-derived dendritic cells (MPDDCs) Blockade of RAGE, using pharmacological antagonists or transgenic mice in which a signaling-deficient RAGE mutant is expressed in cells of mononuclear phagocyte lineage, significantly increases survival after massive liver resection. In the first hours after massive resection, remnants retrieved from RAGE-blocked mice displayed increased activated NF-kappaB principally in hepatocytes, and enhanced expression of regeneration-promoting cytokines, TNF-alpha and IL-6 and the antiinflammatory cytokine, IL-10. Hepatocyte proliferation was increased by RAGE blockade, in parallel with significantly reduced apoptosis. These data highlight central roles for RAGE and MPDCCs in modulation of cell death-promoting mechanisms in massive hepatectomy and suggest that RAGE blockade is a novel strategy to promote regeneration in the massively injured liver.},
  author       = {Cataldegirmen, Guellue and Zeng, Shan and Feirt, Nikki and Ippagunta, Nikalesh and Dun, Hao and Qu, Wu and Lu, Yan and Rong, Ling Ling and Hofmann, Marion A and Kislinger, Thomas and Pachydaki, Sophia I and Jenkins, Daniel G and Weinberg, Alan and Lefkowitch, Jay and Rogiers, Xavier and Yan, Shi Fang and Schmidt, Ann Marie and Emond, Jean C},
  issn         = {0022-1007},
  journal      = {JOURNAL OF EXPERIMENTAL MEDICINE},
  keywords     = {NECROSIS-FACTOR-ALPHA,GLYCATION END-PRODUCTS,HEPATOCYTE GROWTH-FACTOR,INTERLEUKIN-6-DEFICIENT MICE,PARTIAL-HEPATECTOMY,SIGNALING PATHWAYS,DENDRITIC CELLS,CYCLIN D1,RECEPTOR,ACTIVATION},
  language     = {eng},
  number       = {3},
  pages        = {473--484},
  title        = {RAGE limits regeneration after massive liver injury by coordinated suppression TNF-α and NF-κB},
  url          = {http://dx.doi.org/10.1084/jem.20040934},
  volume       = {201},
  year         = {2005},
}

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