Advanced search
1 file | 1.46 MB

Single-particle tracking for studying nanomaterial dynamics: applications and fundamentals in drug delivery

Elisa Zagato (UGent) , Katrien Forier (UGent) , Thomas Martens (UGent) , Kristiaan Neyts (UGent) , Jo Demeester (UGent) , Stefaan De Smedt (UGent) , Katrien Remaut (UGent) and Kevin Braeckmans (UGent)
(2014) NANOMEDICINE. 9(6). p.913-927
Author
Organization
Project
NB-Photonics
Abstract
Many macromolecular therapeutics could potentially treat genetic disorders and cancer. They have, however, not yet reached the clinical stage owing to a lack of suitable carriers that can bring the therapeutics from the administration site to the subcellular site in target cells. One of the reasons that is hindering the development of such carriers is the limited knowledge of their transport dynamics and intracellular processing. Single-particle tracking (SPT) microscopy, thanks to its single molecule sensitivity and its broad applicability, has found its entry in the field of drug delivery to get an answer to these questions. This review aims to introduce the fundamentals of SPT to the drug delivery community and highlight the most recent discoveries obtained with SPT in the field of drug delivery.
Keywords
HOLOGRAPHIC MICROSCOPY, LIVE CELLS, POLYMERIC NANOPARTICLES, INTRACELLULAR TRAFFICKING, QUANTUM-DOT TRACKING, GENE DELIVERY, NUCLEIC-ACID DELIVERY, NON-DEGRADATIVE PATHWAY, MULTIFOCAL PLANE MICROSCOPY, COMPACTED DNA NANOPARTICLES, transport, single-particle tracking, nanoparticles, fluorescence microscopy, diffusion, drug delivery

Downloads

  • (...).pdf
    • full text
    • |
    • UGent only
    • |
    • PDF
    • |
    • 1.46 MB

Citation

Please use this url to cite or link to this publication:

Chicago
Zagato, Elisa, Katrien Forier, Thomas Martens, Kristiaan Neyts, Jo Demeester, Stefaan De Smedt, Katrien Remaut, and Kevin Braeckmans. 2014. “Single-particle Tracking for Studying Nanomaterial Dynamics: Applications and Fundamentals in Drug Delivery.” Nanomedicine 9 (6): 913–927.
APA
Zagato, E., Forier, K., Martens, T., Neyts, K., Demeester, J., De Smedt, S., Remaut, K., et al. (2014). Single-particle tracking for studying nanomaterial dynamics: applications and fundamentals in drug delivery. NANOMEDICINE, 9(6), 913–927.
Vancouver
1.
Zagato E, Forier K, Martens T, Neyts K, Demeester J, De Smedt S, et al. Single-particle tracking for studying nanomaterial dynamics: applications and fundamentals in drug delivery. NANOMEDICINE. 2014;9(6):913–27.
MLA
Zagato, Elisa, Katrien Forier, Thomas Martens, et al. “Single-particle Tracking for Studying Nanomaterial Dynamics: Applications and Fundamentals in Drug Delivery.” NANOMEDICINE 9.6 (2014): 913–927. Print.
@article{5733271,
  abstract     = {Many macromolecular therapeutics could potentially treat genetic disorders and cancer. They have, however, not yet reached the clinical stage owing to a lack of suitable carriers that can bring the therapeutics from the administration site to the subcellular site in target cells. One of the reasons that is hindering the development of such carriers is the limited knowledge of their transport dynamics and intracellular processing. Single-particle tracking (SPT) microscopy, thanks to its single molecule sensitivity and its broad applicability, has found its entry in the field of drug delivery to get an answer to these questions. This review aims to introduce the fundamentals of SPT to the drug delivery community and highlight the most recent discoveries obtained with SPT in the field of drug delivery.},
  author       = {Zagato, Elisa and Forier, Katrien and Martens, Thomas and Neyts, Kristiaan and Demeester, Jo and De Smedt, Stefaan and Remaut, Katrien and Braeckmans, Kevin},
  issn         = {1743-5889},
  journal      = {NANOMEDICINE},
  language     = {eng},
  number       = {6},
  pages        = {913--927},
  title        = {Single-particle tracking for studying nanomaterial dynamics: applications and fundamentals in drug delivery},
  url          = {http://dx.doi.org/10.2217/NNM.14.43},
  volume       = {9},
  year         = {2014},
}

Altmetric
View in Altmetric
Web of Science
Times cited: