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Allergens and the airway epithelium response: gateway to allergic sensitization

Bart Lambrecht UGent and Hamida Hammad UGent (2014) JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 134(3). p.499-507
abstract
Allergic sensitization to inhaled antigens is common but poorly understood. Although lung epithelial cells were initially merely regarded as a passive barrier impeding allergen penetrance, we now realize that they recognize allergens through expression of pattern recognition receptors and mount an innate immune response driven by activation of nuclear factor kappa B. On allergen recognition, epithelial cells release cytokines, such as IL-1, IL-25, IL-33, thymic stromal lymphopoietin, and GM-CSF, and endogenous danger signals, such as high-mobility group box 1, uric acid, and ATP, that activate the dendritic cell network and other innate immune cells, such as basophils and type 2 innate lymphoid cells. Different allergens stimulate different aspects of this general scheme, and common environmental risk factors for sensitization, such as cigarette smoke and diesel particle exposure, do so as well. All of this is influenced by genetic polymorphisms affecting epithelial pattern recognition, barrier function, and cytokine production. Therefore, epithelial cells are crucial in determining the outcome of allergen inhalation.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
THYMIC STROMAL LYMPHOPOIETIN, INNATE LYMPHOID-CELLS, NF-KAPPA-B, TRANSCRIPTION FACTOR GATA3, LUNG DENDRITIC CELLS, INHALED ANTIGEN, IMMUNE-RESPONSES, BARRIER FUNCTION, TYPE-2 IMMUNITY, HOUSE-DUST MITE, T(H)2, dendritic cells, epithelium, Asthma
journal title
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
J. Allergy Clin. Immunol.
volume
134
issue
3
pages
499 - 507
Web of Science type
Review
Web of Science id
000341372400001
JCR category
IMMUNOLOGY
JCR impact factor
11.476 (2014)
JCR rank
6/148 (2014)
JCR quartile
1 (2014)
ISSN
0091-6749
DOI
10.1016/j.jaci.2014.06.036
project
Ghent researchers on unfolded proteins in inflammatory disease (GROUP-ID)
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5732519
handle
http://hdl.handle.net/1854/LU-5732519
date created
2014-10-21 17:27:42
date last changed
2016-12-19 15:42:15
@article{5732519,
  abstract     = {Allergic sensitization to inhaled antigens is common but poorly understood. Although lung epithelial cells were initially merely regarded as a passive barrier impeding allergen penetrance, we now realize that they recognize allergens through expression of pattern recognition receptors and mount an innate immune response driven by activation of nuclear factor kappa B. On allergen recognition, epithelial cells release cytokines, such as IL-1, IL-25, IL-33, thymic stromal lymphopoietin, and GM-CSF, and endogenous danger signals, such as high-mobility group box 1, uric acid, and ATP, that activate the dendritic cell network and other innate immune cells, such as basophils and type 2 innate lymphoid cells. Different allergens stimulate different aspects of this general scheme, and common environmental risk factors for sensitization, such as cigarette smoke and diesel particle exposure, do so as well. All of this is influenced by genetic polymorphisms affecting epithelial pattern recognition, barrier function, and cytokine production. Therefore, epithelial cells are crucial in determining the outcome of allergen inhalation.},
  author       = {Lambrecht, Bart and Hammad, Hamida},
  issn         = {0091-6749},
  journal      = {JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY},
  keyword      = {THYMIC STROMAL LYMPHOPOIETIN,INNATE LYMPHOID-CELLS,NF-KAPPA-B,TRANSCRIPTION FACTOR GATA3,LUNG DENDRITIC CELLS,INHALED ANTIGEN,IMMUNE-RESPONSES,BARRIER FUNCTION,TYPE-2 IMMUNITY,HOUSE-DUST MITE,T(H)2,dendritic cells,epithelium,Asthma},
  language     = {eng},
  number       = {3},
  pages        = {499--507},
  title        = {Allergens and the airway epithelium response: gateway to allergic sensitization},
  url          = {http://dx.doi.org/10.1016/j.jaci.2014.06.036},
  volume       = {134},
  year         = {2014},
}

Chicago
Lambrecht, Bart, and Hamida Hammad. 2014. “Allergens and the Airway Epithelium Response: Gateway to Allergic Sensitization.” Journal of Allergy and Clinical Immunology 134 (3): 499–507.
APA
Lambrecht, Bart, & Hammad, H. (2014). Allergens and the airway epithelium response: gateway to allergic sensitization. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 134(3), 499–507.
Vancouver
1.
Lambrecht B, Hammad H. Allergens and the airway epithelium response: gateway to allergic sensitization. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY. 2014;134(3):499–507.
MLA
Lambrecht, Bart, and Hamida Hammad. “Allergens and the Airway Epithelium Response: Gateway to Allergic Sensitization.” JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 134.3 (2014): 499–507. Print.