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Non-invasive technique for assessment of vascular wall stiffness using laser Doppler vibrometry

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Center for nano- and biophotonics (NB-Photonics)
Abstract
It has been shown that in cardiovascular risk management, stiffness of large arteries has a very good predictive value for cardiovascular disease and mortality. This parameter is best known when estimated from the pulse wave velocity (PWV) measured between the common carotid artery (CCA) in the neck and femoral artery in the groin, but may also be determined locally from short-distance measurements on a short vessel segment. In this work, we propose a novel, non-invasive, non-contact laser Doppler vibrometry (LDV) technique for evaluating PWV locally in an elastic vessel. First, the method was evaluated in a phantom setup using LDV and a reference method. Values correlated significantly between methods (R <= 0.973 (p <= 0.01)); and a Bland-Altman analysis indicated that the mean bias was reasonably small (mean bias <= -2.33 ms). Additionally, PWV was measured locally on the skin surface of the CCA in 14 young healthy volunteers. As a preliminary validation, PWV measured on two locations along the same artery was compared. Local PWV was found to be between 3 and 20 m s(-1), which is in line with the literature (PWV = 5-13 m s(-1)). PWV assessed on two different locations on the same artery correlated significantly (R = 0.684 (p < 0.01)). In summary, we conclude that this new non-contact method is a promising technique to measure local vascular stiffness in a fully non-invasive way, providing new opportunities for clinical diagnosing.
Keywords
screening, arteriosclerosis, vascular stiffness, pulse wave velocity, laser Doppler vibrometry, ULTRASOUND, SEPARATION, SPEED, PRESSURE, CAROTID-ARTERY, INTERFEROMETER, HYPERTENSIVE PATIENTS, PULSE-WAVE VELOCITY, ARTERIAL STIFFNESS

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Citation

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Chicago
Campo, Adriaan, Patrick Segers, Hilde Heuten, Inge Goovaerts, Guy Ennekens, Christiaan Vrints, Roel Baets, and Joris Dirckx. 2014. “Non-invasive Technique for Assessment of Vascular Wall Stiffness Using Laser Doppler Vibrometry.” Measurement Science & Technology 25 (6).
APA
Campo, A., Segers, P., Heuten, H., Goovaerts, I., Ennekens, G., Vrints, C., Baets, R., et al. (2014). Non-invasive technique for assessment of vascular wall stiffness using laser Doppler vibrometry. MEASUREMENT SCIENCE & TECHNOLOGY, 25(6). Presented at the 11th International Symposium on Measurement Technology and Intelligent Instruments (ISMTII).
Vancouver
1.
Campo A, Segers P, Heuten H, Goovaerts I, Ennekens G, Vrints C, et al. Non-invasive technique for assessment of vascular wall stiffness using laser Doppler vibrometry. MEASUREMENT SCIENCE & TECHNOLOGY. 2014;25(6).
MLA
Campo, Adriaan, Patrick Segers, Hilde Heuten, et al. “Non-invasive Technique for Assessment of Vascular Wall Stiffness Using Laser Doppler Vibrometry.” MEASUREMENT SCIENCE & TECHNOLOGY 25.6 (2014): n. pag. Print.
@article{5724154,
  abstract     = {It has been shown that in cardiovascular risk management, stiffness of large arteries has a very good predictive value for cardiovascular disease and mortality. This parameter is best known when estimated from the pulse wave velocity (PWV) measured between the common carotid artery (CCA) in the neck and femoral artery in the groin, but may also be determined locally from short-distance measurements on a short vessel segment. In this work, we propose a novel, non-invasive, non-contact laser Doppler vibrometry (LDV) technique for evaluating PWV locally in an elastic vessel. First, the method was evaluated in a phantom setup using LDV and a reference method. Values correlated significantly between methods (R <= 0.973 (p <= 0.01)); and a Bland-Altman analysis indicated that the mean bias was reasonably small (mean bias <= -2.33 ms). Additionally, PWV was measured locally on the skin surface of the CCA in 14 young healthy volunteers. As a preliminary validation, PWV measured on two locations along the same artery was compared. Local PWV was found to be between 3 and 20 m s(-1), which is in line with the literature (PWV = 5-13 m s(-1)). PWV assessed on two different locations on the same artery correlated significantly (R = 0.684 (p < 0.01)). In summary, we conclude that this new non-contact method is a promising technique to measure local vascular stiffness in a fully non-invasive way, providing new opportunities for clinical diagnosing.},
  articleno    = {065701},
  author       = {Campo, Adriaan and Segers, Patrick and Heuten, Hilde and Goovaerts, Inge and Ennekens, Guy and Vrints, Christiaan and Baets, Roel and Dirckx, Joris},
  issn         = {1361-6501},
  journal      = {MEASUREMENT SCIENCE & TECHNOLOGY},
  keywords     = {screening,arteriosclerosis,vascular stiffness,pulse wave velocity,laser Doppler vibrometry,ULTRASOUND,SEPARATION,SPEED,PRESSURE,CAROTID-ARTERY,INTERFEROMETER,HYPERTENSIVE PATIENTS,PULSE-WAVE VELOCITY,ARTERIAL STIFFNESS},
  language     = {eng},
  location     = {Aachen, GERMANY},
  number       = {6},
  title        = {Non-invasive technique for assessment of vascular wall stiffness using laser Doppler vibrometry},
  url          = {http://dx.doi.org/10.1088/0957-0233/25/6/065701},
  volume       = {25},
  year         = {2014},
}

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