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How has urinary proteomics contributed to the discovery of early biomarkers of acute kidney injury?

Jorien De Loor (UGent) , Kris Gevaert (UGent) , Eric Hoste (UGent) and Evelyne Meyer (UGent)
(2014) EXPERT REVIEW OF PROTEOMICS. 11(4). p.415-424
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Abstract
In the past decade, analysis of the urinary proteome (urinary proteomics) has intensified in response to the need for novel biomarkers that support early diagnosis of kidney diseases. In particular, this also applies to acute kidney injury, which is a heterogeneous complex syndrome with a still-increasing incidence at the intensive care unit. Unfortunately, this major need remains largely unmet to date. The current report aims to explain why attempts to implement urinary proteomic-discovered acute kidney injury diagnostic candidates in the intensive care unit setting have not yet led to success. Subsequently, some key notes are provided that should enhance the chance of translating selected urinary proteomic candidates to valuable tools for the nephrologist and intensivist in the near future.
Keywords
animal model, acute kidney injury, diagnostic biomarker, early detection, intensive care unit, urinary proteomics, CRITICALLY-ILL PATIENTS, ACUTE-RENAL-FAILURE, GELATINASE-ASSOCIATED LIPOCALIN, ISCHEMIA-REPERFUSION INJURY, NEPHROLOGY CONSULTATION, CARDIAC-SURGERY, RIFLE CRITERIA, BLOOD-FLOW, RAT MODEL, SEPSIS

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Chicago
De Loor, Jorien, Kris Gevaert, Eric Hoste, and Evelyne Meyer. 2014. “How Has Urinary Proteomics Contributed to the Discovery of Early Biomarkers of Acute Kidney Injury?” Expert Review of Proteomics 11 (4): 415–424.
APA
De Loor, J., Gevaert, K., Hoste, E., & Meyer, E. (2014). How has urinary proteomics contributed to the discovery of early biomarkers of acute kidney injury? EXPERT REVIEW OF PROTEOMICS, 11(4), 415–424.
Vancouver
1.
De Loor J, Gevaert K, Hoste E, Meyer E. How has urinary proteomics contributed to the discovery of early biomarkers of acute kidney injury? EXPERT REVIEW OF PROTEOMICS. 2014;11(4):415–24.
MLA
De Loor, Jorien, Kris Gevaert, Eric Hoste, et al. “How Has Urinary Proteomics Contributed to the Discovery of Early Biomarkers of Acute Kidney Injury?” EXPERT REVIEW OF PROTEOMICS 11.4 (2014): 415–424. Print.
@article{5722218,
  abstract     = {In the past decade, analysis of the urinary proteome (urinary proteomics) has intensified in response to the need for novel biomarkers that support early diagnosis of kidney diseases. In particular, this also applies to acute kidney injury, which is a heterogeneous complex syndrome with a still-increasing incidence at the intensive care unit. Unfortunately, this major need remains largely unmet to date. The current report aims to explain why attempts to implement urinary proteomic-discovered acute kidney injury diagnostic candidates in the intensive care unit setting have not yet led to success. Subsequently, some key notes are provided that should enhance the chance of translating selected urinary proteomic candidates to valuable tools for the nephrologist and intensivist in the near future.},
  author       = {De Loor, Jorien and Gevaert, Kris and Hoste, Eric and Meyer, Evelyne},
  issn         = {1478-9450},
  journal      = {EXPERT REVIEW OF PROTEOMICS},
  keyword      = {animal model,acute kidney injury,diagnostic biomarker,early detection,intensive care unit,urinary proteomics,CRITICALLY-ILL PATIENTS,ACUTE-RENAL-FAILURE,GELATINASE-ASSOCIATED LIPOCALIN,ISCHEMIA-REPERFUSION INJURY,NEPHROLOGY CONSULTATION,CARDIAC-SURGERY,RIFLE CRITERIA,BLOOD-FLOW,RAT MODEL,SEPSIS},
  language     = {eng},
  number       = {4},
  pages        = {415--424},
  title        = {How has urinary proteomics contributed to the discovery of early biomarkers of acute kidney injury?},
  url          = {http://dx.doi.org/10.1586/14789450.2014.932252},
  volume       = {11},
  year         = {2014},
}

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