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How has urinary proteomics contributed to the discovery of early biomarkers of acute kidney injury?

Jorien De Loor UGent, Kris Gevaert UGent, Eric Hoste UGent and Evelyne Meyer UGent (2014) EXPERT REVIEW OF PROTEOMICS. 11(4). p.415-424
abstract
In the past decade, analysis of the urinary proteome (urinary proteomics) has intensified in response to the need for novel biomarkers that support early diagnosis of kidney diseases. In particular, this also applies to acute kidney injury, which is a heterogeneous complex syndrome with a still-increasing incidence at the intensive care unit. Unfortunately, this major need remains largely unmet to date. The current report aims to explain why attempts to implement urinary proteomic-discovered acute kidney injury diagnostic candidates in the intensive care unit setting have not yet led to success. Subsequently, some key notes are provided that should enhance the chance of translating selected urinary proteomic candidates to valuable tools for the nephrologist and intensivist in the near future.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
animal model, acute kidney injury, diagnostic biomarker, early detection, intensive care unit, urinary proteomics, CRITICALLY-ILL PATIENTS, ACUTE-RENAL-FAILURE, GELATINASE-ASSOCIATED LIPOCALIN, ISCHEMIA-REPERFUSION INJURY, NEPHROLOGY CONSULTATION, CARDIAC-SURGERY, RIFLE CRITERIA, BLOOD-FLOW, RAT MODEL, SEPSIS
journal title
EXPERT REVIEW OF PROTEOMICS
Expert Rev. Proteomics
volume
11
issue
4
pages
415 - 424
Web of Science type
Review
Web of Science id
000342232500003
JCR category
BIOCHEMICAL RESEARCH METHODS
JCR impact factor
2.896 (2014)
JCR rank
30/79 (2014)
JCR quartile
2 (2014)
ISSN
1478-9450
DOI
10.1586/14789450.2014.932252
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5722218
handle
http://hdl.handle.net/1854/LU-5722218
date created
2014-10-15 09:55:24
date last changed
2016-12-19 15:40:04
@article{5722218,
  abstract     = {In the past decade, analysis of the urinary proteome (urinary proteomics) has intensified in response to the need for novel biomarkers that support early diagnosis of kidney diseases. In particular, this also applies to acute kidney injury, which is a heterogeneous complex syndrome with a still-increasing incidence at the intensive care unit. Unfortunately, this major need remains largely unmet to date. The current report aims to explain why attempts to implement urinary proteomic-discovered acute kidney injury diagnostic candidates in the intensive care unit setting have not yet led to success. Subsequently, some key notes are provided that should enhance the chance of translating selected urinary proteomic candidates to valuable tools for the nephrologist and intensivist in the near future.},
  author       = {De Loor, Jorien and Gevaert, Kris and Hoste, Eric and Meyer, Evelyne},
  issn         = {1478-9450},
  journal      = {EXPERT REVIEW OF PROTEOMICS},
  keyword      = {animal model,acute kidney injury,diagnostic biomarker,early detection,intensive care unit,urinary proteomics,CRITICALLY-ILL PATIENTS,ACUTE-RENAL-FAILURE,GELATINASE-ASSOCIATED LIPOCALIN,ISCHEMIA-REPERFUSION INJURY,NEPHROLOGY CONSULTATION,CARDIAC-SURGERY,RIFLE CRITERIA,BLOOD-FLOW,RAT MODEL,SEPSIS},
  language     = {eng},
  number       = {4},
  pages        = {415--424},
  title        = {How has urinary proteomics contributed to the discovery of early biomarkers of acute kidney injury?},
  url          = {http://dx.doi.org/10.1586/14789450.2014.932252},
  volume       = {11},
  year         = {2014},
}

Chicago
De Loor, Jorien, Kris Gevaert, Eric Hoste, and Evelyne Meyer. 2014. “How Has Urinary Proteomics Contributed to the Discovery of Early Biomarkers of Acute Kidney Injury?” Expert Review of Proteomics 11 (4): 415–424.
APA
De Loor, J., Gevaert, K., Hoste, E., & Meyer, E. (2014). How has urinary proteomics contributed to the discovery of early biomarkers of acute kidney injury? EXPERT REVIEW OF PROTEOMICS, 11(4), 415–424.
Vancouver
1.
De Loor J, Gevaert K, Hoste E, Meyer E. How has urinary proteomics contributed to the discovery of early biomarkers of acute kidney injury? EXPERT REVIEW OF PROTEOMICS. 2014;11(4):415–24.
MLA
De Loor, Jorien, Kris Gevaert, Eric Hoste, et al. “How Has Urinary Proteomics Contributed to the Discovery of Early Biomarkers of Acute Kidney Injury?” EXPERT REVIEW OF PROTEOMICS 11.4 (2014): 415–424. Print.