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The diagnostic value of SE MRI and DWI of the spine in patients with monoclonal gammopathy of undetermined significance, smouldering myeloma and multiple myeloma

Julie Dutoit, Matthias Vanderkerken UGent, Joris Anthonissen, Frederick Dochy and Koenraad Verstraete UGent (2014) EUROPEAN RADIOLOGY. 24(11). p.2754-2765
abstract
Objectives: To evaluate DWI of the bone marrow in the differentiation of monoclonal gammopathy of undetermined significance (MGUS), smouldering myeloma (SMM) and multiple myeloma (MM). Methods The retrospective study includes 64 patients with MGUS, 27 with SMM, 64 with new MM and 12 controls. Signal intensity (SI) of spinal SE-MRI and DWI (b0-1000) as well as apparent diffusion coefficients (ADC) were measured in the T10 and L3. Qualitative assessment of b-images was performed by one experienced radiologist. Results: ADC600 and ADC1000 are the best ADC values in differentiating patient groups (p<0.030). SIT2, SIb1000 and ADC1000 are higher and SIT1 lower in L3 compared to T10 (p<0.050). All quantitative parameters of L3 can differentiate significantly between MGUS and MM (p<0.050) and between patients with percentage plasma cells (PC%) between 0-10 % compared to >50 % (p=0.001). Only SIT2 for L3 can differentiate MGUS from SMM (p=0.044) and PC%0-10 from PC%10-25 (p=0.033). Qualitative interpretation of b1000 images allows differentiating MM patients from those with MGUS or SMM (p<0.001). Conclusions: Spinal SE-MRI can differentiate among MGUS, SMM, MM and control subjects. DWI based on the SI on b1000 images and ADC values is increased in MM compared to MGUS and SMM. Qualitative assessment of b-images can differentiate MM from MGUS or SMM. Key points: - ADC values are higher in patients with MM compared to MGUS - DWI parameters change late in disease evolution - DWI is sensitive but not specific in diagnosing patients with MM - Qualitative DWI assessment is good in detecting myeloma patients
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (original)
publication status
published
subject
keyword
Diffusion-weightedimaging, Multiple myeloma, Monoclonal gammopathy of undetermined significance, Diagnosis, Magnetic resonance imaging, APPARENT DIFFUSION-COEFFICIENT, CONTRAST-ENHANCED MRI, BONE-MARROW, PRECURSOR DISEASE, WEIGHTED MRI, DCE-MRI, INSIGHTS, CANCER
journal title
EUROPEAN RADIOLOGY
Eur. Radiol.
volume
24
issue
11
pages
2754 - 2765
Web of Science type
Article
Web of Science id
000343140100011
JCR category
RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING
JCR impact factor
4.014 (2014)
JCR rank
14/125 (2014)
JCR quartile
1 (2014)
ISSN
0938-7994
DOI
10.1007/s00330-014-3324-5
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5718376
handle
http://hdl.handle.net/1854/LU-5718376
date created
2014-10-07 08:34:20
date last changed
2016-12-19 15:39:19
@article{5718376,
  abstract     = {Objectives: To evaluate DWI of the bone marrow in the differentiation of monoclonal gammopathy of undetermined significance (MGUS), smouldering myeloma (SMM) and multiple myeloma (MM).
Methods The retrospective study includes 64 patients with MGUS, 27 with SMM, 64 with new MM and 12 controls. Signal intensity (SI) of spinal SE-MRI and DWI (b0-1000) as well as apparent diffusion coefficients (ADC) were measured in the T10 and L3. Qualitative assessment of b-images was performed by one experienced radiologist.
Results: ADC600 and ADC1000 are the best ADC values in differentiating patient groups (p{\textlangle}0.030). SIT2, SIb1000 and ADC1000 are higher and SIT1 lower in L3 compared to T10 (p{\textlangle}0.050). All quantitative parameters of L3 can differentiate significantly between MGUS and MM (p{\textlangle}0.050) and between patients with percentage plasma cells (PC\%) between 0-10 \% compared to {\textrangle}50 \% (p=0.001). Only SIT2 for L3 can differentiate MGUS from SMM (p=0.044) and PC\%0-10 from PC\%10-25 (p=0.033). Qualitative interpretation of b1000 images allows differentiating MM patients from those with MGUS or SMM (p{\textlangle}0.001).
Conclusions: Spinal SE-MRI can differentiate among MGUS, SMM, MM and control subjects. DWI based on the SI on b1000 images and ADC values is increased in MM compared to MGUS and SMM. Qualitative assessment of b-images can differentiate MM from MGUS or SMM.
Key points:
- ADC values are higher in patients with MM compared to MGUS
- DWI parameters change late in disease evolution
- DWI is sensitive but not specific in diagnosing patients with MM
- Qualitative DWI assessment is good in detecting myeloma patients},
  author       = {Dutoit, Julie and Vanderkerken, Matthias and Anthonissen, Joris and Dochy, Frederick and Verstraete, Koenraad},
  issn         = {0938-7994},
  journal      = {EUROPEAN RADIOLOGY},
  keyword      = {Diffusion-weightedimaging,Multiple myeloma,Monoclonal gammopathy of undetermined significance,Diagnosis,Magnetic resonance imaging,APPARENT DIFFUSION-COEFFICIENT,CONTRAST-ENHANCED MRI,BONE-MARROW,PRECURSOR DISEASE,WEIGHTED MRI,DCE-MRI,INSIGHTS,CANCER},
  language     = {eng},
  number       = {11},
  pages        = {2754--2765},
  title        = {The diagnostic value of SE MRI and DWI of the spine in patients with monoclonal gammopathy of undetermined significance, smouldering myeloma and multiple myeloma},
  url          = {http://dx.doi.org/10.1007/s00330-014-3324-5},
  volume       = {24},
  year         = {2014},
}

Chicago
Dutoit, Julie, Matthias Vanderkerken, Joris Anthonissen, Frederick Dochy, and Koenraad Verstraete. 2014. “The Diagnostic Value of SE MRI and DWI of the Spine in Patients with Monoclonal Gammopathy of Undetermined Significance, Smouldering Myeloma and Multiple Myeloma.” European Radiology 24 (11): 2754–2765.
APA
Dutoit, J., Vanderkerken, M., Anthonissen, J., Dochy, F., & Verstraete, K. (2014). The diagnostic value of SE MRI and DWI of the spine in patients with monoclonal gammopathy of undetermined significance, smouldering myeloma and multiple myeloma. EUROPEAN RADIOLOGY, 24(11), 2754–2765.
Vancouver
1.
Dutoit J, Vanderkerken M, Anthonissen J, Dochy F, Verstraete K. The diagnostic value of SE MRI and DWI of the spine in patients with monoclonal gammopathy of undetermined significance, smouldering myeloma and multiple myeloma. EUROPEAN RADIOLOGY. 2014;24(11):2754–65.
MLA
Dutoit, Julie, Matthias Vanderkerken, Joris Anthonissen, et al. “The Diagnostic Value of SE MRI and DWI of the Spine in Patients with Monoclonal Gammopathy of Undetermined Significance, Smouldering Myeloma and Multiple Myeloma.” EUROPEAN RADIOLOGY 24.11 (2014): 2754–2765. Print.