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Engineering complex metabolic pathways in plants

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Abstract
Metabolic engineering can be used to modulate endogenous metabolic pathways in plants or introduce new metabolic capabilities in order to increase the production of a desirable compound or reduce the accumulation of an undesirable one. In practice, there are several major challenges that need to be overcome, such as gaining enough knowledge about the endogenous pathways to understand the best intervention points, identifying and sourcing the most suitable metabolic genes, expressing those genes in such a way as to produce a functional enzyme in a heterologous background, and, finally, achieving the accumulation of target compounds without harming the host plant. This article discusses the strategies that have been developed to engineer complex metabolic pathways in plants, focusing on recent technological developments that allow the most significant bottlenecks to be overcome.
Keywords
metabolic diversity, multigene engineering, metabolic branch, metabolic conversion, metabolic bottleneck

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Chicago
Farré, Gemma, Dieter Blancquaert, Teresa Capell, Dominique Van Der Straeten, Paul Christou, and Changfu Zhu. 2014. “Engineering Complex Metabolic Pathways in Plants.” Ed. SS Merchant. Annual Review of Plant Biology 65: 187–223.
APA
Farré, G., Blancquaert, D., Capell, T., Van Der Straeten, D., Christou, P., & Zhu, C. (2014). Engineering complex metabolic pathways in plants. (SS Merchant, Ed.)Annual Review of Plant Biology, 65, 187–223.
Vancouver
1.
Farré G, Blancquaert D, Capell T, Van Der Straeten D, Christou P, Zhu C. Engineering complex metabolic pathways in plants. Merchant S, editor. Annual Review of Plant Biology. Palo Alto, CA, USA: Annual Reviews; 2014;65:187–223.
MLA
Farré, Gemma, Dieter Blancquaert, Teresa Capell, et al. “Engineering Complex Metabolic Pathways in Plants.” Ed. SS Merchant. Annual Review of Plant Biology 65 (2014): 187–223. Print.
@article{5714568,
  abstract     = {Metabolic engineering can be used to modulate endogenous metabolic pathways in plants or introduce new metabolic capabilities in order to increase the production of a desirable compound or reduce the accumulation of an undesirable one. In practice, there are several major challenges that need to be overcome, such as gaining enough knowledge about the endogenous pathways to understand the best intervention points, identifying and sourcing the most suitable metabolic genes, expressing those genes in such a way as to produce a functional enzyme in a heterologous background, and, finally, achieving the accumulation of target compounds without harming the host plant. This article discusses the strategies that have been developed to engineer complex metabolic pathways in plants, focusing on recent technological developments that allow the most significant bottlenecks to be overcome.},
  author       = {Farré, Gemma and Blancquaert, Dieter and Capell, Teresa and Van Der Straeten, Dominique and Christou, Paul and Zhu, Changfu},
  editor       = {Merchant, SS},
  isbn         = {9780824306656},
  issn         = {1543-5008},
  journal      = {Annual Review of Plant Biology},
  keywords     = {metabolic diversity,multigene engineering,metabolic branch,metabolic conversion,metabolic bottleneck},
  language     = {eng},
  pages        = {187--223},
  publisher    = {Annual Reviews},
  title        = {Engineering complex metabolic pathways in plants},
  url          = {http://dx.doi.org/10.1146/annurev-arplant-050213-035825},
  volume       = {65},
  year         = {2014},
}

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