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Engineering complex metabolic pathways in plants

Gemma Farré, Dieter Blancquaert, Teresa Capell, Dominique Van Der Straeten UGent, Paul Christou and Changfu Zhu (2014) Annual Review of Plant Biology. In Annual Review of Plant Biology 65. p.187-223
abstract
Metabolic engineering can be used to modulate endogenous metabolic pathways in plants or introduce new metabolic capabilities in order to increase the production of a desirable compound or reduce the accumulation of an undesirable one. In practice, there are several major challenges that need to be overcome, such as gaining enough knowledge about the endogenous pathways to understand the best intervention points, identifying and sourcing the most suitable metabolic genes, expressing those genes in such a way as to produce a functional enzyme in a heterologous background, and, finally, achieving the accumulation of target compounds without harming the host plant. This article discusses the strategies that have been developed to engineer complex metabolic pathways in plants, focusing on recent technological developments that allow the most significant bottlenecks to be overcome.
Please use this url to cite or link to this publication:
author
organization
year
type
journalArticle (review)
publication status
published
subject
keyword
metabolic diversity, multigene engineering, metabolic branch, metabolic conversion, metabolic bottleneck
journal title
Annual Review of Plant Biology
Annu. Rev. Plant Biol.
editor
SS Merchant
series title
Annual Review of Plant Biology
volume
65
pages
187 - 223
publisher
Annual Reviews
place of publication
Palo Alto, CA, USA
Web of Science type
Review; Book Chapter
Web of Science id
000340193000009
JCR category
PLANT SCIENCES
JCR impact factor
23.3 (2014)
JCR rank
1/204 (2014)
JCR quartile
1 (2014)
ISSN
1543-5008
ISBN
9780824306656
DOI
10.1146/annurev-arplant-050213-035825
language
English
UGent publication?
yes
classification
A1
copyright statement
I have transferred the copyright for this publication to the publisher
id
5714568
handle
http://hdl.handle.net/1854/LU-5714568
date created
2014-10-01 11:09:11
date last changed
2017-01-02 09:53:59
@article{5714568,
  abstract     = {Metabolic engineering can be used to modulate endogenous metabolic pathways in plants or introduce new metabolic capabilities in order to increase the production of a desirable compound or reduce the accumulation of an undesirable one. In practice, there are several major challenges that need to be overcome, such as gaining enough knowledge about the endogenous pathways to understand the best intervention points, identifying and sourcing the most suitable metabolic genes, expressing those genes in such a way as to produce a functional enzyme in a heterologous background, and, finally, achieving the accumulation of target compounds without harming the host plant. This article discusses the strategies that have been developed to engineer complex metabolic pathways in plants, focusing on recent technological developments that allow the most significant bottlenecks to be overcome.},
  author       = {Farr{\'e}, Gemma and Blancquaert, Dieter and Capell, Teresa and Van Der Straeten, Dominique and Christou, Paul and Zhu, Changfu},
  editor       = {Merchant, SS},
  isbn         = {9780824306656},
  issn         = {1543-5008},
  journal      = {Annual Review of Plant Biology},
  keyword      = {metabolic diversity,multigene engineering,metabolic branch,metabolic conversion,metabolic bottleneck},
  language     = {eng},
  pages        = {187--223},
  publisher    = {Annual Reviews},
  title        = {Engineering complex metabolic pathways in plants},
  url          = {http://dx.doi.org/10.1146/annurev-arplant-050213-035825},
  volume       = {65},
  year         = {2014},
}

Chicago
Farré, Gemma, Dieter Blancquaert, Teresa Capell, Dominique Van Der Straeten, Paul Christou, and Changfu Zhu. 2014. “Engineering Complex Metabolic Pathways in Plants.” Ed. SS Merchant. Annual Review of Plant Biology 65: 187–223.
APA
Farré, G., Blancquaert, D., Capell, T., Van Der Straeten, D., Christou, P., & Zhu, C. (2014). Engineering complex metabolic pathways in plants. (SS Merchant, Ed.)Annual Review of Plant Biology, 65, 187–223.
Vancouver
1.
Farré G, Blancquaert D, Capell T, Van Der Straeten D, Christou P, Zhu C. Engineering complex metabolic pathways in plants. Merchant S, editor. Annual Review of Plant Biology. Palo Alto, CA, USA: Annual Reviews; 2014;65:187–223.
MLA
Farré, Gemma, Dieter Blancquaert, Teresa Capell, et al. “Engineering Complex Metabolic Pathways in Plants.” Ed. SS Merchant. Annual Review of Plant Biology 65 (2014): 187–223. Print.