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Magnetic electrospun fibers for cancer therapy

(2012) ADVANCED FUNCTIONAL MATERIALS. 22(12). p.2479-2486
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Abstract
Iron oxide nanoparticles (IONPs) for magnetic hyperthermia in cancer treatment have recently gained substantial interest. Unfortunately, the use of free IONPs still faces major challenges such as poor tumor targetability, high variability in the amount of IONPs taken up by the tumor and the IONP leakage from dead cancer cells into the surrounding healthy tissues. The present work reports on electrospun fiber webs, heavily loaded with 50 nm sized IONPs. The high loading capacity of the fibers enables significant heating of the environment upon applying an alternating magnetic field. Furthermore, magnetic fibers can be repeatedly heated without loss of heating capacity or release of IONPs. Upon functionalization of the fiber surface with collagen, human SKOV-3 ovarian cancer cells attached well to the fibers. Applying an alternating magnetic field during 10 minutes to the fiber webs killed all fiber-associated cancer cells. Killing the cells using this method seemed more efficient compared to the use of a warm water bath. As the fiber webs can be i) loaded with a well-controlled amount of IONPs and ii) localized in the body by Magnetic Resonance Imaging, magnetic electrospun fibers may become promising materials for a highly reproducible (repeated) heating of cancer tissues in vivo.
Keywords
magnetic hyperthermia, electrospinning, iron oxide nanoparticle, cancer, IRON-OXIDE NANOPARTICLES, FERRIMAGNETIC PARTICLES, PHYSICAL EVALUATION, HYPERTHERMIA, NANOFIBERS, MAGNETOLIPOSOMES, GLIOBLASTOMA, DELIVERY, FLUIDS, RATS

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Citation

Please use this url to cite or link to this publication:

MLA
Huang, Chaobo, Stefaan Soenen, Joanna Rejman, et al. “Magnetic Electrospun Fibers for Cancer Therapy.” ADVANCED FUNCTIONAL MATERIALS 22.12 (2012): 2479–2486. Print.
APA
Huang, Chaobo, Soenen, S., Rejman, J., Trekker, J., Chengxun, L., Lagae, L., Ceelen, W., et al. (2012). Magnetic electrospun fibers for cancer therapy. ADVANCED FUNCTIONAL MATERIALS, 22(12), 2479–2486.
Chicago author-date
Huang, Chaobo, Stefaan Soenen, Joanna Rejman, Jesse Trekker, Liu Chengxun, Liesbet Lagae, Wim Ceelen, Claire Wilhelm, Jo Demeester, and Stefaan De Smedt. 2012. “Magnetic Electrospun Fibers for Cancer Therapy.” Advanced Functional Materials 22 (12): 2479–2486.
Chicago author-date (all authors)
Huang, Chaobo, Stefaan Soenen, Joanna Rejman, Jesse Trekker, Liu Chengxun, Liesbet Lagae, Wim Ceelen, Claire Wilhelm, Jo Demeester, and Stefaan De Smedt. 2012. “Magnetic Electrospun Fibers for Cancer Therapy.” Advanced Functional Materials 22 (12): 2479–2486.
Vancouver
1.
Huang C, Soenen S, Rejman J, Trekker J, Chengxun L, Lagae L, et al. Magnetic electrospun fibers for cancer therapy. ADVANCED FUNCTIONAL MATERIALS. 2012;22(12):2479–86.
IEEE
[1]
C. Huang et al., “Magnetic electrospun fibers for cancer therapy,” ADVANCED FUNCTIONAL MATERIALS, vol. 22, no. 12, pp. 2479–2486, 2012.
@article{5710723,
  abstract     = {Iron oxide nanoparticles (IONPs) for magnetic hyperthermia in cancer treatment have recently gained substantial interest. Unfortunately, the use of free IONPs still faces major challenges such as poor tumor targetability, high variability in the amount of IONPs taken up by the tumor and the IONP leakage from dead cancer cells into the surrounding healthy tissues. The present work reports on electrospun fiber webs, heavily loaded with 50 nm sized IONPs. The high loading capacity of the fibers enables significant heating of the environment upon applying an alternating magnetic field. Furthermore, magnetic fibers can be repeatedly heated without loss of heating capacity or release of IONPs. Upon functionalization of the fiber surface with collagen, human SKOV-3 ovarian cancer cells attached well to the fibers. Applying an alternating magnetic field during 10 minutes to the fiber webs killed all fiber-associated cancer cells. Killing the cells using this method seemed more efficient compared to the use of a warm water bath. As the fiber webs can be i) loaded with a well-controlled amount of IONPs and ii) localized in the body by Magnetic Resonance Imaging, magnetic electrospun fibers may become promising materials for a highly reproducible (repeated) heating of cancer tissues in vivo.},
  author       = {Huang, Chaobo and Soenen, Stefaan and Rejman, Joanna and Trekker, Jesse and Chengxun, Liu and Lagae, Liesbet and Ceelen, Wim and Wilhelm, Claire and Demeester, Jo and De Smedt, Stefaan},
  issn         = {1616-301X},
  journal      = {ADVANCED FUNCTIONAL MATERIALS},
  keywords     = {magnetic hyperthermia,electrospinning,iron oxide nanoparticle,cancer,IRON-OXIDE NANOPARTICLES,FERRIMAGNETIC PARTICLES,PHYSICAL EVALUATION,HYPERTHERMIA,NANOFIBERS,MAGNETOLIPOSOMES,GLIOBLASTOMA,DELIVERY,FLUIDS,RATS},
  language     = {eng},
  number       = {12},
  pages        = {2479--2486},
  title        = {Magnetic electrospun fibers for cancer therapy},
  url          = {http://dx.doi.org/10.1002/adfm.201102171},
  volume       = {22},
  year         = {2012},
}

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