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Anterograde and retrograde regulation of nuclear genes encoding mitochondrial proteins during growth, development, and stress

(2014) MOLECULAR PLANT. 7(7). p.1075-1093
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Biotechnology for a sustainable economy (Bio-Economy)
Abstract
Mitochondrial biogenesis and function in plants require the expression of over 1000 nuclear genes encoding mitochondrial proteins (NGEMPs). The expression of these genes is regulated by tissue-specific, developmental, internal, and external stimuli that result in a dynamic organelle involved in both metabolic and a variety of signaling processes. Although the metabolic and biosynthetic machinery of mitochondria is relatively well understood, the factors that regulate these processes and the various signaling pathways involved are only beginning to be identified at a molecular level. The molecular components of anterograde (nuclear to mitochondrial) and retrograde (mitochondrial to nuclear) signaling pathways that regulate the expression of NGEMPs interact with chloroplast-, growth-, and stress-signaling pathways in the cell at a variety of levels, with common components involved in transmission and execution of these signals. This positions mitochondria as important hubs for signaling in the cell, not only in direct signaling of mitochondrial function per se, but also in sensing and/or integrating a variety of other internal and external signals. This integrates and optimizes growth with energy metabolism and stress responses, which is required in both photosynthetic and non-photosynthetic cells.
Keywords
RESPIRATORY-CHAIN, ARABIDOPSIS-THALIANA, REACTIVE OXYGEN, ENDOPLASMIC-RETICULUM, ALTERNATIVE OXIDASE, mitochondrial retrograde regulation (MRR), organellar crosstalk, signaling, OXIDATIVE STRESS, mitochondria, CHAIN COMPLEX I, NAC TRANSCRIPTION FACTOR, PROGRAMMED CELL-DEATH, PSEUDO-RESPONSE REGULATORS

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Citation

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Chicago
Ng, Sophia, Inge De Clercq, Olivier Van Aken, Simon R Law, Aneta Ivanova, Patrick Willems, Estelle Giraud, Frank Van Breusegem, and James Whelan. 2014. “Anterograde and Retrograde Regulation of Nuclear Genes Encoding Mitochondrial Proteins During Growth, Development, and Stress.” Molecular Plant 7 (7): 1075–1093.
APA
Ng, Sophia, De Clercq, I., Van Aken, O., Law, S. R., Ivanova, A., Willems, P., Giraud, E., et al. (2014). Anterograde and retrograde regulation of nuclear genes encoding mitochondrial proteins during growth, development, and stress. MOLECULAR PLANT, 7(7), 1075–1093.
Vancouver
1.
Ng S, De Clercq I, Van Aken O, Law SR, Ivanova A, Willems P, et al. Anterograde and retrograde regulation of nuclear genes encoding mitochondrial proteins during growth, development, and stress. MOLECULAR PLANT. 2014;7(7):1075–93.
MLA
Ng, Sophia, Inge De Clercq, Olivier Van Aken, et al. “Anterograde and Retrograde Regulation of Nuclear Genes Encoding Mitochondrial Proteins During Growth, Development, and Stress.” MOLECULAR PLANT 7.7 (2014): 1075–1093. Print.
@article{5709762,
  abstract     = {Mitochondrial biogenesis and function in plants require the expression of over 1000 nuclear genes encoding mitochondrial proteins (NGEMPs). The expression of these genes is regulated by tissue-specific, developmental, internal, and external stimuli that result in a dynamic organelle involved in both metabolic and a variety of signaling processes. Although the metabolic and biosynthetic machinery of mitochondria is relatively well understood, the factors that regulate these processes and the various signaling pathways involved are only beginning to be identified at a molecular level. The molecular components of anterograde (nuclear to mitochondrial) and retrograde (mitochondrial to nuclear) signaling pathways that regulate the expression of NGEMPs interact with chloroplast-, growth-, and stress-signaling pathways in the cell at a variety of levels, with common components involved in transmission and execution of these signals. This positions mitochondria as important hubs for signaling in the cell, not only in direct signaling of mitochondrial function per se, but also in sensing and/or integrating a variety of other internal and external signals. This integrates and optimizes growth with energy metabolism and stress responses, which is required in both photosynthetic and non-photosynthetic cells.},
  author       = {Ng, Sophia and De Clercq, Inge and Van Aken, Olivier and Law, Simon R and Ivanova, Aneta and Willems, Patrick and Giraud, Estelle and Van Breusegem, Frank and Whelan, James},
  issn         = {1674-2052},
  journal      = {MOLECULAR PLANT},
  language     = {eng},
  number       = {7},
  pages        = {1075--1093},
  title        = {Anterograde and retrograde regulation of nuclear genes encoding mitochondrial proteins during growth, development, and stress},
  url          = {http://dx.doi.org/10.1093/mp/ssu037},
  volume       = {7},
  year         = {2014},
}

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